Fenticonazole nitrate
Fenticonazole nitrate structure
|
Common Name | Fenticonazole nitrate | ||
|---|---|---|---|---|
| CAS Number | 73151-29-8 | Molecular Weight | 518.412 | |
| Density | 1.26g/cm3 | Boiling Point | 637.2ºC at 760 mmHg | |
| Molecular Formula | C24H21Cl2N3O4S | Melting Point | 135-137ºC | |
| MSDS | N/A | Flash Point | 339.2ºC | |
Use of Fenticonazole nitrateFenticonazole Nitrate is an azole antifungal agent.Target: AntifungalFenticonazole is an azole antifungal drug, used locally as the nitrate in the treatment of vulvovaginal candidiasis. It is active against a range of organisms including dermatophyte pathogens, Malassezia furfur, and Candida albicans. Application of fenticonazole nitrate 1 g intravaginal ovules on 2 alternate days is a suitable first-line treatment of vulvovaginitis with acceptable broad-spectrum efficacy against the most commonly involved pathogens and with a low rate of early relapse, reserving antibiotics for patients with treatment failure or relapse of infection [1]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | fenticonazole nitrate |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Fenticonazole Nitrate is an azole antifungal agent.Target: AntifungalFenticonazole is an azole antifungal drug, used locally as the nitrate in the treatment of vulvovaginal candidiasis. It is active against a range of organisms including dermatophyte pathogens, Malassezia furfur, and Candida albicans. Application of fenticonazole nitrate 1 g intravaginal ovules on 2 alternate days is a suitable first-line treatment of vulvovaginitis with acceptable broad-spectrum efficacy against the most commonly involved pathogens and with a low rate of early relapse, reserving antibiotics for patients with treatment failure or relapse of infection [1]. |
|---|---|
| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.26g/cm3 |
|---|---|
| Boiling Point | 637.2ºC at 760 mmHg |
| Melting Point | 135-137ºC |
| Molecular Formula | C24H21Cl2N3O4S |
| Molecular Weight | 518.412 |
| Flash Point | 339.2ºC |
| Exact Mass | 517.062988 |
| PSA | 118.40000 |
| LogP | 7.47470 |
| Index of Refraction | 1.632 |
| InChIKey | FJNRUWDGCVDXLU-UHFFFAOYSA-N |
| SMILES | Clc1ccc(C(Cn2ccnc2)OCc2ccc(Sc3ccccc3)cc2)c(Cl)c1.O=[N+]([O-])O |
| Storage condition | Refrigerator |
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Hazard Codes | Xi,Xn |
|---|---|
| Risk Phrases | R36/37/38:Irritating to eyes, respiratory system and skin . R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . |
| Safety Phrases | S26 |
| HS Code | 2942000000 |
This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2942000000 |
|---|
This table lists relevant public references with title, journal and publication metadata for this compound.
|
In vitro activity of cloconazole, sulconazole, butoconazole, isoconazole, fenticonazole, and five other antifungal agents against clinical isolates of Candida albicans and Candida spp.
Mycopathologia 118(1) , 15-21, (1992) The in vitro activity of several new imidazoles, cloconazole, sulconazole, butoconazole, isoconazole and fenticonazole, were compared with those of amphothericin B, flucytosine, and three azoles: econ... |
|
|
Fenticonazole activity measured by the methods of the European Committee on Antimicrobial Susceptibility Testing and CLSI against 260 Candida vulvovaginitis isolates from two European regions and annotations on the prevalent genotypes.
Antimicrob. Agents Chemother. 53 , 2181-4, (2009) The activity of fenticonazole was studied against 260 West and Southeast European vulvovaginal candidiasis isolates, and low MICs were displayed. Fenticonazole was assessed by European Committee on An... |
|
|
Single dose therapy of vaginal candidiasis: a comparative trial of fenticonazole vaginal ovules versus clotrimazole vaginal tablets.
Curr. Med. Res. Opin. 12(2) , 114-20, (1990) An open, randomized comparative clinical trial was performed in 153 patients suffering from symptomatic vaginal candidiasis confirmed by mycological tests. Patients were allocated at random into two g... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| 1H-Imidazole, 1-[2-(2,4-dichlorophenyl)-2-[[4-(phenylthio)phenyl]methoxy]ethyl]-, nitrate (1:1) |
| Lomexin |
| EINECS 277-302-6 |
| 1-[2-(2,4-dichlorophenyl)-2-[(4-phenylsulfanylphenyl)methoxy]ethyl]imidazole,nitric acid |
| MFCD00941391 |
| Falvin |
| REC 15/1476 |
| Fenticonazole nitrate (USAN) |
| Fenticonazole (Nitrate) |
| Fenticonazole mononitrate |
| 1-(2-(2,4-Dichlorophenyl)-2-((4-(phenylthio)phenyl)methoxy)ethyl)-1H-imidazolium nitrate |
| 1-[2-(2,4-Dichlorophenyl)-2-{[4-(phenylsulfanyl)benzyl]oxy}ethyl]-1H-imidazol-1-ium nitrate |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the safety information for fenticonazole nitrate? |
| A: Safety information for fenticonazole nitrate: S26. |
| Q: What is the SMILES notation of fenticonazole nitrate? |
| A: SMILES notation of fenticonazole nitrate is Clc1ccc(C(Cn2ccnc2)OCc2ccc(Sc3ccccc3)cc2)c(Cl)c1.O=[N+]([O-])O. |
| Q: What is the molecular formula of fenticonazole nitrate? |
| A: Molecular formula of fenticonazole nitrate is C24H21Cl2N3O4S. |
| Q: What is the polar surface area (PSA) of fenticonazole nitrate? |
| A: Polar surface area (PSA) of fenticonazole nitrate is 118.40000. |
| Q: What is the boiling point of fenticonazole nitrate? |
| A: Boiling point of fenticonazole nitrate is 637.2ºC at 760 mmHg. |
| Q: What is the InChIKey of fenticonazole nitrate? |
| A: InChIKey of fenticonazole nitrate is FJNRUWDGCVDXLU-UHFFFAOYSA-N. |
| Q: What are the storage conditions for fenticonazole nitrate? |
| A: Storage conditions for fenticonazole nitrate: Refrigerator. |
| Q: What is the CAS number of fenticonazole nitrate? |
| A: CAS number of fenticonazole nitrate is 73151-29-8. |
| Q: What is the molecular weight of fenticonazole nitrate? |
| A: Molecular weight of fenticonazole nitrate is 518.412. |
| Q: What is the melting point of fenticonazole nitrate? |
| A: Melting point of fenticonazole nitrate is 135-137ºC. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |
| Henan Tianfu Chemical Co., Ltd. |