Iopidine

Modify Date: 2024-01-02 18:50:42

Iopidine Structure
Iopidine structure
 Common Name Iopidine
CAS Number 73218-79-8 Molecular Weight 281.56900
Density 1.63 g/cm3 Boiling Point 395.5ºC at 760 mmHg
Molecular Formula C9H11Cl3N4 Melting Point >230ºC
MSDS Chinese USA Flash Point 193ºC
Symbol GHS06 GHS08
GHS06, GHS08		 Signal Word Danger

 Use of Iopidine


Apraclonidine hydrochloride (ALO 2145), a selective α2 and weak α1 receptor agonist activity, effectively lowers intraocular pressure (IOP) in human eyes. Apraclonidine hydrochloride is a topical ophthalmic solution and has the ability to elevate the eye lid[1][2].

 Names

Name apraclonidine hydrochloride
Synonym More Synonyms

 Iopidine Biological Activity

Description Apraclonidine hydrochloride (ALO 2145), a selective α2 and weak α1 receptor agonist activity, effectively lowers intraocular pressure (IOP) in human eyes. Apraclonidine hydrochloride is a topical ophthalmic solution and has the ability to elevate the eye lid[1][2].
Related Catalog
In Vitro Apraclonidine hydrochloride (ALO 2145) is more commonly used topically for glaucoma, as it penetrates the cornea and blood-brain barrier to a lesser extent and, thus, has fewer adverse systemic effects[2].
In Vivo Apraclonidine hydrochloride (ALO 2145) is effective in animal models of elevated IOP as well as glaucoma in humans. The ocular hypotensive effects of Apraclonidine are usually attributed to reduced aqueous humor synthesis and vasoconstrictor actions at the anterior segment branches of the ophthalmic artery[2].
References

[1]. Wijemanne S, et al. Apraclonidine in the treatment of ptosis. J Neurol Sci. 2017;376:129‐132.

[2]. Searles RV, et al. Aqueous humor dynamics in anesthetized rats infused with intracameral apraclonidine. Pharmacology. 1999;58(4):220‐226.

 Chemical & Physical Properties

Density 1.63 g/cm3
Boiling Point 395.5ºC at 760 mmHg
Melting Point >230ºC
Molecular Formula C9H11Cl3N4
Molecular Weight 281.56900
Flash Point 193ºC
Exact Mass 280.00500
PSA 62.44000
LogP 3.16730
Storage condition 2-8°C
Stability Moisture Sensitive
Water Solubility 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.4 mg/mL Solutions may be stored for several days at 4?#x00b0;C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CZ1582000
CHEMICAL NAME :
1,4-Benzenediamine, 2,6-dichloro-N(sup 1)-(4,5-dihydro-1H-imidazol-2-yl)-, monohydrochloride
CAS REGISTRY NUMBER :
73218-79-8
LAST UPDATED :
199604
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C9-H10-Cl2-N4.Cl-H
MOLECULAR WEIGHT :
281.59

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
38 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 24,557,1988
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
9 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 24,557,1988
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 24,557,1988
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
6 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 24,557,1988

 Safety Information

Symbol GHS06 GHS08
GHS06, GHS08
Signal Word Danger
Hazard Statements H300-H370
Precautionary Statements Missing Phrase - N15.00950417-P308 + P311
Target Organs Cardio-vascular system
Hazard Codes T: Toxic;
Risk Phrases R23/24/25
Safety Phrases 22-36/37/39-45
RIDADR UN 2811
WGK Germany 3
Packaging Group III
Hazard Class 6.1(b)
HS Code 2933290090

 Customs

HS Code 2933290090
Summary 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

UNII-D2VW67N38H
Iopidine ophthalmic solution
MFCD00135922
2-(4-Amino-2,6-dichlorophenylimino)imidazolidine
2-[(4-amino-2,6-dichlorophenyl)imino]imidazolidine monohydrochloride
APRACLONIDINE HYDROCHLORIDE
ALO-2145
2,6-dichloro-1-N-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine,hydrochloride
p-aminoclonidine hydrochloride
NC 14 hydrochloride
2-[(2,6-dichloro-4-aminophenyl)imino]imidazolidine hydrochloride
p-aminoclonidine
mono hydrochloride
Apraclonidine HCl
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Related Compounds: More...
Iopidine
66711-21-5
Chemsrc provides Iopidine(CAS#:73218-79-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Iopidine are included as well.>> amp version: Iopidine

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