1-Deoxymannojirimycin hydrochloride

Modify Date: 2024-01-05 16:07:14

1-Deoxymannojirimycin hydrochloride Structure
1-Deoxymannojirimycin hydrochloride structure
Common Name 1-Deoxymannojirimycin hydrochloride
CAS Number 73465-43-7 Molecular Weight 199.633
Density N/A Boiling Point N/A
Molecular Formula C6H14ClNO4 Melting Point 183-185ºC
MSDS Chinese USA Flash Point N/A
Symbol GHS07
GHS07
Signal Word Warning

 Use of 1-Deoxymannojirimycin hydrochloride


1-Deoxymannojirimycin hydrochloride is a selective class I α1,2-mannosidase inhibitor with an IC50 of 20 μM. 1-Deoxymannojirimycin hydrochloride is also a N-linked glycosylation inhibitor and inhibits HIV‐1 strains. 1-Deoxymannojirimycin hydrochloride has antiviral activity[1][2].

 Names

Name (+)-1-Deoxynojirimycin hydrochloride
Synonym More Synonyms

 1-Deoxymannojirimycin hydrochloride Biological Activity

Description 1-Deoxymannojirimycin hydrochloride is a selective class I α1,2-mannosidase inhibitor with an IC50 of 20 μM. 1-Deoxymannojirimycin hydrochloride is also a N-linked glycosylation inhibitor and inhibits HIV‐1 strains. 1-Deoxymannojirimycin hydrochloride has antiviral activity[1][2].
Related Catalog
Target

IC50: 20 μM (α1,2-mannosidase I)[1] N-linked glycosylation[2] HIV‐1[2]

References

[1]. F Vallee, et al. Structural Basis for Catalysis and Inhibition of N-glycan Processing Class I Alpha 1,2-mannosidases. J Biol Chem. 2000 Dec 29;275(52):41287-98.

[2]. Jan Balzarini, et al. The alpha(1,2)-mannosidase I Inhibitor 1-deoxymannojirimycin Potentiates the Antiviral Activity of Carbohydrate-Binding Agents Against Wild-Type and Mutant HIV-1 Strains Containing Glycan Deletions in gp120. FEBS Lett. 2007 May 15;581(10):2060-4.

 Chemical & Physical Properties

Melting Point 183-185ºC
Molecular Formula C6H14ClNO4
Molecular Weight 199.633
Exact Mass 199.061142
PSA 92.95000
Appearance of Characters Powder | white to off-white
Storage condition 2-8°C
Water Solubility H2O: soluble10mg/mL

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H312-H332
Precautionary Statements P280
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn: Harmful;
Risk Phrases R20/21/22
Safety Phrases 22-24/25-36
RIDADR NONH for all modes of transport
WGK Germany 3

 Articles1

More Articles
Glycosylation of native MHC class Ia molecules is required for recognition by allogeneic cytotoxic T lymphocytes.

Glycobiology 6 , 413-421, (1996)

The question whether or not target cell N-linked carbohydrate participates in cytotoxic T lymphocyte (CTL) mediated cytolysis has been in contention for well over a decade. Much of the evidence suppor...

 Synonyms

(2R,3R,4R,5R)-3,4,5-Trihydroxy-2-(hydroxymethyl)piperidinium chloride
Piperidinium, 3,4,5-trihydroxy-2-(hydroxymethyl)-, chloride, (2R,3R,4R,5R)- (1:1)
1-deoxymannojirimycin hydrochloride
(2R,3R,4R,5R)-2-(Hydroxymethyl)piperidine-3,4,5-triol hydrochloride (1:1)
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