1-Deoxymannojirimycin hydrochloride

Modify Date: 2024-01-05 16:07:14

1-Deoxymannojirimycin hydrochloride structure	Common Name	1-Deoxymannojirimycin hydrochloride
	CAS Number	73465-43-7	Molecular Weight	199.633
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₆H₁₄ClNO₄	Melting Point	183-185ºC
	MSDS	Chinese USA	Flash Point	N/A
	Symbol	GHS07	Signal Word	Warning

Use of 1-Deoxymannojirimycin hydrochloride

1-Deoxymannojirimycin hydrochloride is a selective class I α1,2-mannosidase inhibitor with an IC50 of 20 μM. 1-Deoxymannojirimycin hydrochloride is also a N-linked glycosylation inhibitor and inhibits HIV‐1 strains. 1-Deoxymannojirimycin hydrochloride has antiviral activity[1][2].

Name	(+)-1-Deoxynojirimycin hydrochloride
Synonym	More Synonyms

Description	1-Deoxymannojirimycin hydrochloride is a selective class I α1,2-mannosidase inhibitor with an IC50 of 20 μM. 1-Deoxymannojirimycin hydrochloride is also a N-linked glycosylation inhibitor and inhibits HIV‐1 strains. 1-Deoxymannojirimycin hydrochloride has antiviral activity[1][2].
Related Catalog	Signaling Pathways >> Anti-infection >> Influenza Virus Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection
Target	IC50: 20 μM (α1,2-mannosidase I)[1] N-linked glycosylation[2] HIV‐1[2]
References	[1]. F Vallee, et al. Structural Basis for Catalysis and Inhibition of N-glycan Processing Class I Alpha 1,2-mannosidases. J Biol Chem. 2000 Dec 29;275(52):41287-98. [2]. Jan Balzarini, et al. The alpha(1,2)-mannosidase I Inhibitor 1-deoxymannojirimycin Potentiates the Antiviral Activity of Carbohydrate-Binding Agents Against Wild-Type and Mutant HIV-1 Strains Containing Glycan Deletions in gp120. FEBS Lett. 2007 May 15;581(10):2060-4.

Melting Point	183-185ºC
Molecular Formula	C₆H₁₄ClNO₄
Molecular Weight	199.633
Exact Mass	199.061142
PSA	92.95000
Appearance of Characters	Powder \| white to off-white
Storage condition	2-8°C
Water Solubility	H2O: soluble10mg/mL

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H312-H332
Precautionary Statements	P280
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn: Harmful;
Risk Phrases	R20/21/22
Safety Phrases	22-24/25-36
RIDADR	NONH for all modes of transport
WGK Germany	3

Glycosylation of native MHC class Ia molecules is required for recognition by allogeneic cytotoxic T lymphocytes.

Glycobiology 6 , 413-421, (1996)

The question whether or not target cell N-linked carbohydrate participates in cytotoxic T lymphocyte (CTL) mediated cytolysis has been in contention for well over a decade. Much of the evidence suppor...

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1-deoxymannojirimycin hydrochloride

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