2-[3-(4-Hydroxyphenyl)propyl]-5-methoxyphenol

Modify Date: 2024-01-15 10:10:31

2-[3-(4-Hydroxyphenyl)propyl]-5-methoxyphenol Structure
2-[3-(4-Hydroxyphenyl)propyl]-5-methoxyphenol structure
Common Name 2-[3-(4-Hydroxyphenyl)propyl]-5-methoxyphenol
CAS Number 73731-87-0 Molecular Weight 258.312
Density 1.2±0.1 g/cm3 Boiling Point 439.5±35.0 °C at 760 mmHg
Molecular Formula C16H18O3 Melting Point 101-101.5 °C
MSDS N/A Flash Point 219.6±25.9 °C

 Use of 2-[3-(4-Hydroxyphenyl)propyl]-5-methoxyphenol


Broussonin A is a potent BChE inhibitor, with an IC50 of 4.16 µM. Broussonin A is a diarylpropane natural product that can be isolated from the bark of Broussonetia papyrifera after solid fermentation[1][2][3].

 Names

Name Broussonin A
Synonym More Synonyms

  Biological Activity

Description Broussonin A is a potent BChE inhibitor, with an IC50 of 4.16 µM. Broussonin A is a diarylpropane natural product that can be isolated from the bark of Broussonetia papyrifera after solid fermentation[1][2][3].
Related Catalog
Target

BChE:4.16 μM (IC50)

In Vitro Broussonin A(0.1-10 µM,30 分钟)通过调节细胞周期相关蛋白的表达和视网膜母细胞瘤蛋白的磷酸化状态来抑制 VEGF-A 刺激的内皮细胞增殖[1]。 Broussonin A(0-10 µM,30 分钟)消除 VEGF-A 刺激的血管生成反应,包括大鼠主动脉环的内皮细胞迁移、侵袭、管形成和微血管形成[1]。
References

[1]. Kim JH, et al. Broussonin A- and B-mediated inhibition of angiogenesis by blockade of VEGFR-2 signalling pathways and integrin β1 expression. J Cell Mol Med. 2022 Feb;26(4):1194-1205.  

[2]. Lee JP, et al. Potent inhibition of acetylcholinesterase by sargachromanol I from Sargassum siliquastrum and by selected natural compounds. Bioorg Chem. 2019 Aug;89:103043.  

[3]. Chang C F, et al. Bioactive compounds from the bark of Broussonetia papyrifera after solid fermentation with a white rot fungus Perenniporia tephropora[J]. Journal of Wood Chemistry and Technology, 2020:1-14.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 439.5±35.0 °C at 760 mmHg
Melting Point 101-101.5 °C
Molecular Formula C16H18O3
Molecular Weight 258.312
Flash Point 219.6±25.9 °C
Exact Mass 258.125580
PSA 49.69000
LogP 3.65
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.600

 Synonyms

2-[3-(4-Hydroxyphenyl)propyl]-5-methoxyphenol
Phenol, 2-[3-(4-hydroxyphenyl)propyl]-5-methoxy-
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