CIMOXATONE

Modify Date: 2025-08-21 16:40:32

CIMOXATONE structure	Common Name	CIMOXATONE
	CAS Number	73815-11-9	Molecular Weight	338.35700
	Density	1.29g/cm3	Boiling Point	509.3ºC at 760 mmHg
	Molecular Formula	C₁₉H₁₈N₂O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	261.8ºC

Use of CIMOXATONE

Cimoxatone (MD 780515) is a reversible, selectively and orally active type A monoamine oxidase (MAO-A) inhibitor. Cimoxatone enhances the anorectic action of Serotonin (HY-B1473A)[1].

Name	3-[[4-[5-(methoxymethyl)-2-oxo-1,3-oxazolidin-3-yl]phenoxy]methyl]benzonitrile
Synonym	More Synonyms

Description	Cimoxatone (MD 780515) is a reversible, selectively and orally active type A monoamine oxidase (MAO-A) inhibitor. Cimoxatone enhances the anorectic action of Serotonin (HY-B1473A)[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase Research Areas >> Metabolic Disease
Target	MAO-A
In Vivo	Cimoxatone (20 mg/kg; p.o.) 增强 5-HT (1 mg/kg; s.c.) 对大鼠的厌食作用[1]。 Animal Model: 250-300 g, Adult male Wistar rats[1] Dosage: 20 mg/kg Administration: P.o. Result: Significiantly reduced sucrose intake induced by 1 mg/kg 5-HT or its vehicle injected 2 and 24 h later, significantly enhanced the anorectic action of 5-HT at 2 h but not at 24 h.

Density	1.29g/cm3
Boiling Point	509.3ºC at 760 mmHg
Molecular Formula	C₁₉H₁₈N₂O₄
Molecular Weight	338.35700
Flash Point	261.8ºC
Exact Mass	338.12700
PSA	71.79000
LogP	3.17388
Index of Refraction	1.613
InChIKey	MVVJINIUPYKZHR-UHFFFAOYSA-N
SMILES	COCC1CN(c2ccc(OCc3cccc(C#N)c3)cc2)C(=O)O1

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DI4710000

CHEMICAL NAME :: Benzonitrile, 3-((4-(5-(methoxymethyl)-2-oxo-3-oxazolidinyl)phenoxy )methyl)-

CAS REGISTRY NUMBER :: 73815-11-9

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C19-H18-N2-O4

MOLECULAR WEIGHT :: 338.39

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 259,194,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 259,194,1982

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 259,194,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 259,194,1982

Cimoxatone

Cimoxatone (INN)

Cimoxatonum [INN-Latin]

EINECS 277-613-7

Cimoxatono [INN-Spanish]

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Cimoxatone
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: Cimoxatone
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Delivery: 10 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: CIMOXATONE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.