Leukotriene D4
Leukotriene D4 structure
|
Common Name | Leukotriene D4 | ||
|---|---|---|---|---|
| CAS Number | 73836-78-9 | Molecular Weight | 496.660 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 748.3±70.0 °C at 760 mmHg | |
| Molecular Formula | C25H40N2O6S | Melting Point | N/A | |
| MSDS | USA | Flash Point | 406.4±35.7 °C | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
Use of Leukotriene D4Leukotriene D4 is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) produced by the metabolism of LTC4 by γ-glutamyl transpeptidase. Leukotriene D4 is the first cysteinyl-leukotriene metabolite of LTC4. Leukotriene D4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute hypersensitivity. |
| Name | leukotriene D4 |
|---|---|
| Synonym | More Synonyms |
| Description | Leukotriene D4 is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) produced by the metabolism of LTC4 by γ-glutamyl transpeptidase. Leukotriene D4 is the first cysteinyl-leukotriene metabolite of LTC4. Leukotriene D4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute hypersensitivity. |
|---|
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 748.3±70.0 °C at 760 mmHg |
| Molecular Formula | C25H40N2O6S |
| Molecular Weight | 496.660 |
| Flash Point | 406.4±35.7 °C |
| Exact Mass | 496.260712 |
| PSA | 175.25000 |
| LogP | 5.78 |
| Vapour Pressure | 0.0±5.7 mmHg at 25°C |
| Index of Refraction | 1.538 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATAMUTATION DATA
|
| Symbol |
GHS02, GHS06, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H225-H301 + H311 + H331-H370 |
| Precautionary Statements | P210-P260-P280-P301 + P310 + P330-P302 + P352 + P312-P370 + P378 |
| Personal Protective Equipment | Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter |
| Hazard Codes | F: Flammable;T: Toxic; |
| Risk Phrases | R11 |
| Safety Phrases | 7-16-36/37-45 |
| RIDADR | UN 1230 3/PG 2 |
|
Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing.
Nat. Neurosci. 18(1) , 145-53, (2015) The primary sensory system requires the integrated function of multiple cell types, although its full complexity remains unclear. We used comprehensive transcriptome analysis of 622 single mouse neuro... |
|
|
Cutting edge: Leukotriene C4 activates mouse platelets in plasma exclusively through the type 2 cysteinyl leukotriene receptor.
J. Immunol. 191(12) , 5807-10, (2013) Leukotriene C4 (LTC4) and its extracellular metabolites, LTD4 and LTE4, mediate airway inflammation. They signal through three specific receptors (type 1 cys-LT receptor [CysLT1R], CysLT2R, and GPR99)... |
|
|
A contraction assay system using primary cultured mouse bronchial smooth muscle cells.
Int. Arch. Allergy Immunol. 161 Suppl 2 , 93-7, (2013) Contraction of bronchial smooth muscle is the main mechanism of asthmatic responses. Inflammatory cells such as eosinophils and mast cells produce chemical mediators that induce smooth muscle contract... |
| (5S,6R,7E,9E,11Z,14Z)-6-({(2R,3Z)-2-Amino-3-[(carboxymethyl)imino]-3-hydroxypropyl}sulfanyl)-5-hydroxy-7,9,11,14-icosatetraenoic acid |
| Glycine, S-[(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]-2,4,6,9-pentadecatetraen-1-yl]-L-cysteinyl- |
| Leukotriene D4 |
| LTD4 |
| S-[(4S,5R,6E,8E,10Z,13Z)-1-Carboxy-4-hydroxy-6,8,10,13-nonadecatetraen-5-yl]-L-cysteinylglycine |
| 7,9,11,14-Eicosatetraenoic acid, 6-[[(2R,3Z)-2-amino-3-[(carboxymethyl)imino]-3-hydroxypropyl]thio]-5-hydroxy-, (5S,6R,7E,9E,11Z,14Z)- |
| leukotriened |