2',3',5'-Tri-O-acetyladenosine

Modify Date: 2024-01-03 19:27:41

2',3',5'-Tri-O-acetyladenosine Structure
2',3',5'-Tri-O-acetyladenosine structure
Common Name 2',3',5'-Tri-O-acetyladenosine
CAS Number 7387-57-7 Molecular Weight 393.35
Density 1.6±0.1 g/cm3 Boiling Point 594.1±60.0 °C at 760 mmHg
Molecular Formula C16H19N5O7 Melting Point 168-170ºC
MSDS USA Flash Point 313.1±32.9 °C

 Use of 2',3',5'-Tri-O-acetyladenosine


2’,3’,5’-Tri-O-acetyl adenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277)[1].

 Names

Name 2',3',5'-Tri-O-acetyl-D-adenosine
Synonym More Synonyms

 2',3',5'-Tri-O-acetyladenosine Biological Activity

Description 2’,3’,5’-Tri-O-acetyl adenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277)[1].
Related Catalog
References

[1]. Man S, et al. Potential and promising anticancer drugs from adenosine and its analogs. Drug Discov Today. 2021 Jun;26(6):1490-1500.  

 Chemical & Physical Properties

Density 1.6±0.1 g/cm3
Boiling Point 594.1±60.0 °C at 760 mmHg
Melting Point 168-170ºC
Molecular Formula C16H19N5O7
Molecular Weight 393.35
Flash Point 313.1±32.9 °C
Exact Mass 393.128448
PSA 157.75000
LogP 0.99
Vapour Pressure 0.0±1.7 mmHg at 25°C
Index of Refraction 1.680
Storage condition −20°C

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
RIDADR NONH for all modes of transport
WGK Germany 3

 Synthetic Route

 Articles2

More Articles
Detection of proton-acceptor sites of hydrogen bonding in adenine X uracil base pairs by the use of 15N magnetic resonance.

Eur. J. Biochem. 117(3) , 553-8, (1981)

2',3',5'-Tri-O-acetyl[1,3,7,9,amino-15N]adenosine(ac3Ado) and its 8-2H and 8-bromo derivatives (ac3[8-2H]Ado and ac3br8Ado) were synthesized from 95% 15N-enriched adenosine which was obtained by micro...

An 15N NMR study of adenine-uracil base pair in a non-aqueous solvent.

Nucleic Acids Symp. Ser. (6) , s79-82, (1979)

[1,3,7,9,10-15N]-2',3',5'-Tri-O-acetyl adenosine (A) and its 8-D and 8-Br derivatives (AD and ABr) were prepared from 95% 15N enriched adenosine obtained from microbial fermentation. The chemical shif...

 Synonyms

MFCD00057001
Tri-O-acetyladenosine
2',3',5'-Tri-O-acetyladenosine
Adenosine, 2',3',5'-triacetate