Clofentezine

Modify Date: 2024-01-02 17:59:57

Clofentezine structure	Common Name	Clofentezine
	CAS Number	74115-24-5	Molecular Weight	303.14600
	Density	1.398g/cm3	Boiling Point	504.4ºC at 760 mmHg
	Molecular Formula	C₁₄H₈Cl₂N₄	Melting Point	182-185 °C(lit.)
	MSDS	Chinese USA	Flash Point	290.4ºC
	Symbol	GHS07, GHS09	Signal Word	Warning

Use of Clofentezine

Clofentezine, a growth inhibitor, has sublethal effects on life-table parameters of Tetranychus urticae Koch females.

Name	clofentezine
Synonym	More Synonyms

Description	Clofentezine, a growth inhibitor, has sublethal effects on life-table parameters of Tetranychus urticae Koch females.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Others
References	[1]. Marcic D. The effects of clofentezine on life-table parameters in two-spotted spider mite Tetranychus urticae. Exp Appl Acarol. 2003;30(4):249-63. [2]. Peter Demaeght, et al. High resolution genetic mapping uncovers chitin synthase-1 as the target-site of the structurally diverse mite growth inhibitors clofentezine, hexythiazox and etoxazole in Tetranychus urticae. Insect Biochem Mol Biol. 2014 Aug; 51: 52–61. [3]. Li D, et al. Assessment of sublethal effects of clofentezine on life-table parameters in Hawthorn spider mite (Tetranychus viennensis). Exp Appl Acarol. 2006;38(4):255-73.

Description

Clofentezine, a growth inhibitor, has sublethal effects on life-table parameters of Tetranychus urticae Koch females.

Related Catalog

Signaling Pathways >> Others >> Others

Research Areas >> Others

References

[1]. Marcic D. The effects of clofentezine on life-table parameters in two-spotted spider mite Tetranychus urticae. Exp Appl Acarol. 2003;30(4):249-63.

[2]. Peter Demaeght, et al. High resolution genetic mapping uncovers chitin synthase-1 as the target-site of the structurally diverse mite growth inhibitors clofentezine, hexythiazox and etoxazole in Tetranychus urticae. Insect Biochem Mol Biol. 2014 Aug; 51: 52–61.

[3]. Li D, et al. Assessment of sublethal effects of clofentezine on life-table parameters in Hawthorn spider mite (Tetranychus viennensis). Exp Appl Acarol. 2006;38(4):255-73.

Density	1.398g/cm3
Boiling Point	504.4ºC at 760 mmHg
Melting Point	182-185 °C(lit.)
Molecular Formula	C₁₄H₈Cl₂N₄
Molecular Weight	303.14600
Flash Point	290.4ºC
Exact Mass	302.01300
PSA	51.56000
LogP	3.90740
Index of Refraction	1.634
Storage condition	0-6°C

Clofentezine MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XF6860000

CHEMICAL NAME :: 1,2,4,5-Tetrazine, 3,6-bis(2-chlorophenyl)-

CAS REGISTRY NUMBER :: 74115-24-5

LAST UPDATED :: 199701

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C14-H8-Cl2-N4

MOLECULAR WEIGHT :: 303.16

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >3200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PBCDDQ Proceedings-British Crop Protection Conference-Pests and Diseases. (British Crop., Protection Council, 2A Kidderminster Rd., Croydon, CRO 2UE, UK) 1977- Volume(issue)/page/year: -,67,1981

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >9 gm/m3/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,177,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >1332 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86 Volume(issue)/page/year: A543,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >3200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PBCDDQ Proceedings-British Crop Protection Conference-Pests and Diseases. (British Crop., Protection Council, 2A Kidderminster Rd., Croydon, CRO 2UE, UK) 1977- Volume(issue)/page/year: -,67,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: >750 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PBCDDQ Proceedings-British Crop Protection Conference-Pests and Diseases. (British Crop., Protection Council, 2A Kidderminster Rd., Croydon, CRO 2UE, UK) 1977- Volume(issue)/page/year: -,67,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - duck

DOSE/DURATION :: >3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PBCDDQ Proceedings-British Crop Protection Conference-Pests and Diseases. (British Crop., Protection Council, 2A Kidderminster Rd., Croydon, CRO 2UE, UK) 1977- Volume(issue)/page/year: -,67,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Bird - duck

DOSE/DURATION :: >3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DEVEAA Defense des Vegetaux. (Federation Nationale des Groupements de Protection des Cultures, 149, rue de Bercy, 75595 Paris Cedex, 12, France) V.1- 1947- Volume(issue)/page/year: 39(231),11,1985

Symbol	GHS07, GHS09
Signal Word	Warning
Hazard Statements	H312-H400
Precautionary Statements	P273-P280
Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	T+
Safety Phrases	S22-S24/25
RIDADR	UN 3077 9 / PGIII
WGK Germany	3
RTECS	XF6860000
HS Code	2933990012

Precursor 2
CAS#:74115-15-4 3,6-BIS(2-CHLOR... CAS#:873-32-5 2-Chlorobenzonitrile
DownStream 0

HS Code	2933990012
Summary	2933990012. VAT:17.0%. Tax rebate rate:9.0%. Supervision conditions:S(import or export registration certificate for pesticides). MFN tariff:6.5%. General tariff:20.0%

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MFCD00143998

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