KIN-281

Modify Date: 2024-01-18 20:18:47

KIN-281 Structure
KIN-281 structure
Common Name KIN-281
CAS Number 74151-26-1 Molecular Weight 506.898
Density 1.3±0.1 g/cm3 Boiling Point 599.2±50.0 °C at 760 mmHg
Molecular Formula C25H30Cl3N5 Melting Point N/A
MSDS N/A Flash Point 316.2±30.1 °C

 Use of KIN-281


KIN-281 is a small molecule that inhibits multiple kinases including MELK and the non-receptor tyrosine kinase BMX with IC50 of 1.4 and 1.9 uM, respectively; also inhibits BLK, CAMK Iiγ/δ, CAMK Iα, Tie2, BTK with IC50 of 1-10 uM; inhibit STAT3 activation, autophagy and cancer cell anchorage-independent growth in MDA-MB-231 and MDA-MB-468 breast cancer cells.

 Names

Name N4-[5-(Diethylamino)-2-pentanyl]-2-[(E)-2-(2,4,6-trichlorophenyl)vinyl]-4,6-quinazolinediamine
Synonym More Synonyms

 KIN-281 Biological Activity

Description KIN-281 is a small molecule that inhibits multiple kinases including MELK and the non-receptor tyrosine kinase BMX with IC50 of 1.4 and 1.9 uM, respectively; also inhibits BLK, CAMK Iiγ/δ, CAMK Iα, Tie2, BTK with IC50 of 1-10 uM; inhibit STAT3 activation, autophagy and cancer cell anchorage-independent growth in MDA-MB-231 and MDA-MB-468 breast cancer cells.
References References 1. Zhou D, et al. Bioorg Med Chem. 2017 Jun 15;25(12):2995-3005. View Related Products by Target MELK

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 599.2±50.0 °C at 760 mmHg
Molecular Formula C25H30Cl3N5
Molecular Weight 506.898
Flash Point 316.2±30.1 °C
Exact Mass 505.156677
LogP 5.26
Vapour Pressure 0.0±1.7 mmHg at 25°C
Index of Refraction 1.676

 Synonyms

4,6-Quinazolinediamine, N4-[4-(diethylamino)-1-methylbutyl]-2-[(E)-2-(2,4,6-trichlorophenyl)ethenyl]-
N4-[5-(Diethylamino)pentan-2-yl]-2-[(E)-2-(2,4,6-trichlorophenyl)vinyl]quinazoline-4,6-diamine
N4-[5-(Diethylamino)-2-pentanyl]-2-[(E)-2-(2,4,6-trichlorophenyl)vinyl]-4,6-quinazolinediamine
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