4-tert-butyl-1,3-thiazol-2-amine

Modify Date: 2024-01-19 11:16:18

4-tert-butyl-1,3-thiazol-2-amine Structure
4-tert-butyl-1,3-thiazol-2-amine structure
Common Name 4-tert-butyl-1,3-thiazol-2-amine
CAS Number 74370-93-7 Molecular Weight 156.24900
Density 1.107 g/cm3 Boiling Point 253.2ºC at 760 mmHg
Molecular Formula C7H12N2S Melting Point 99-102 °C
MSDS N/A Flash Point 106.9ºC

 Names

Name 2-amino-4-tert-butylthiazole
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.107 g/cm3
Boiling Point 253.2ºC at 760 mmHg
Melting Point 99-102 °C
Molecular Formula C7H12N2S
Molecular Weight 156.24900
Flash Point 106.9ºC
Exact Mass 156.07200
PSA 67.15000
LogP 2.60400
Index of Refraction 1.555

 MSDS

Name: 2-Amino-4-tert-butylthiazole Material Safety Data Sheet
Synonym: None Known
CAS: 74370-93-7
Section 1 - Chemical Product MSDS Name:2-Amino-4-tert-butylthiazole Material Safety Data Sheet
Synonym:None Known

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
74370-93-7 2-Amino-4-tert-butylthiazole 99 unlisted
Hazard Symbols: XI
Risk Phrases: 36/37/38

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Irritating to eyes, respiratory system and skin.
Potential Health Effects
Eye:
Causes eye irritation. May cause chemical conjunctivitis.
Skin:
Causes skin irritation. May be harmful if absorbed through the skin.
Ingestion:
May cause irritation of the digestive tract. May be harmful if swallowed.
Inhalation:
Causes respiratory tract irritation. May be harmful if inhaled. Can produce delayed pulmonary edema.
Chronic:
No information found.

Section 4 - FIRST AID MEASURES
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Do NOT use mouth-to-mouth resuscitation.
Notes to Physician:
Treat symptomatically and supportively.

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation.

Section 7 - HANDLING and STORAGE
Handling:
Minimize dust generation and accumulation. Avoid breathing dust, vapor, mist, or gas. Avoid contact with eyes, skin, and clothing.
Keep container tightly closed. Avoid ingestion and inhalation. Use with adequate ventilation. Wash clothing before reuse.
Storage:
Store in a cool, dry place. Store in a tightly closed container.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 74370-93-7: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Crystals
Color: yellow - fine
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 99 - 100 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C7H12N2S
Molecular Weight: 156.25

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Dust generation.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong bases, strong acids.
Hazardous Decomposition Products:
Hydrogen cyanide, sulfur dioxide, carbon monoxide, oxides of nitrogen, carbon dioxide, sulfuric acid, nitric acid.
Hazardous Polymerization: Has not been reported

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 74370-93-7 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
2-Amino-4-tert-butylthiazole - Not listed by ACGIH, IARC, or NTP.

Section 12 - ECOLOGICAL INFORMATION


Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XI
Risk Phrases:
R 36/37/38 Irritating to eyes, respiratory system
and skin.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 37/39 Wear suitable gloves and eye/face
protection.
WGK (Water Danger/Protection)
CAS# 74370-93-7: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 74370-93-7 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 74370-93-7 is not listed on the TSCA inventory.
It is for research and development use only.


SECTION 16 - ADDITIONAL INFORMATION
N/A

 Safety Information

Hazard Codes Xi:Irritant;
Risk Phrases R36/37/38
Safety Phrases S39-S26
HS Code 2934100090

 Synthetic Route

~90%

4-tert-butyl-1,3-thiazol-2-amine Structure

4-tert-butyl-1,...

CAS#:74370-93-7

Literature: Institute of Medicinal Molecular Design, Inc. Patent: EP1514544 A1, 2005 ; Location in patent: Page/Page column 152 ;

~92%

4-tert-butyl-1,3-thiazol-2-amine Structure

4-tert-butyl-1,...

CAS#:74370-93-7

Literature: Institute of Medicinal Molecular Design, Inc. Patent: EP1352650 A1, 2003 ;

~87%

4-tert-butyl-1,3-thiazol-2-amine Structure

4-tert-butyl-1,...

CAS#:74370-93-7

Literature: Yadav; Reddy, B.V. Subba; Rao, Y. Gopala; Narsaiah Tetrahedron Letters, 2008 , vol. 49, # 15 p. 2381 - 2383

~80%

4-tert-butyl-1,3-thiazol-2-amine Structure

4-tert-butyl-1,...

CAS#:74370-93-7

Literature: Kumar, V. Pavan; Narender; Sridhar; Nageswar; Rao, K. Rama Synthetic Communications, 2007 , vol. 37, # 24 p. 4331 - 4336

~%

4-tert-butyl-1,3-thiazol-2-amine Structure

4-tert-butyl-1,...

CAS#:74370-93-7

Literature: Journal of the American Chemical Society, , vol. 72, p. 3722

~12%

4-tert-butyl-1,3-thiazol-2-amine Structure

4-tert-butyl-1,...

CAS#:74370-93-7

Literature: Chemische Berichte, , vol. 121, p. 533 - 546

 Customs

HS Code 2934100090
Summary 2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

 Synonyms

4-tert-butyl-1,3-thiazol-2-amine
MFCD00051644