Bromoform

Modify Date: 2026-07-01 00:20:23

Bromoform structure	Common Name	Bromoform
	CAS Number	75-25-2	Molecular Weight	186.291
	Density	0.9±0.1 g/cm3	Boiling Point	203.9±8.0 °C at 760 mmHg
	Molecular Formula	CHBr₃	Melting Point	8 °C
	MSDS	Chinese USA	Flash Point	78.9±5.4 °C
	Symbol	GHS02, GHS06, GHS08	Signal Word	Danger

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	bromoform
Synonym	More Synonyms

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	0.9±0.1 g/cm3
Boiling Point	203.9±8.0 °C at 760 mmHg
Melting Point	8 °C
Molecular Formula	CHBr₃
Molecular Weight	186.291
Flash Point	78.9±5.4 °C
Exact Mass	186.161987
LogP	4.06
Vapour density	8.7 (vs air)
Vapour Pressure	0.3±0.4 mmHg at 25°C
Index of Refraction	1.424
Stability	Stability May be an explosion hazard, especially when heated. Stable, but light-sensitive. Non-flammable. Incompatible with chemically active metals, strong bases. May contain ca 1% ethanol or 1-pentene (amylene) as a stabilizer.
Water Solubility	slightly soluble, 0.301 g/100 mL

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

Bromoform MSDS(Chinese)

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: PB5600000

CHEMICAL NAME :: Methane, tribromo-

CAS REGISTRY NUMBER :: 75-25-2

BEILSTEIN REFERENCE NO. :: 1731048

LAST UPDATED :: 199712

DATA ITEMS CITED :: 64

MOLECULAR FORMULA :: C-H-Br3

MOLECULAR WEIGHT :: 252.75

WISWESSER LINE NOTATION :: EYEE

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 143 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 933 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 45 gm/m3/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 414 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Behavioral - somnolence (general depressed activity) Behavioral - antipsychotic

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1072 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1274 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1820 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 410 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 12100 mg/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6230 mg/kg/4W-C

TOXIC EFFECTS :: Liver - other changes Liver - changes in liver weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 13 gm/kg/13W-I

TOXIC EFFECTS :: Liver - other changes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5600 mg/kg/14D-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5840 mg/kg/1Y-C

TOXIC EFFECTS :: Kidney, Ureter, Bladder - other changes in urine composition

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3500 mg/kg/14D-I

TOXIC EFFECTS :: Liver - changes in liver weight Endocrine - changes in spleen weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6500 mg/kg/13W-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10400 mg/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1100 mg/kg/8W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors

TYPE OF TEST :: Specific locus test

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: Sister chromatid exchange

TYPE OF TEST :: Sister chromatid exchange

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

REFERENCE :: ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 7,1,1985 *** REVIEWS *** ACGIH TLV-Animal carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 5.2 mg/m3 (0.5 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 52,213,1991 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 52,213,1991 IARC Cancer Review:Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 52,213,1991 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 0.5 ppm (5 mg/m3) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,28,1971 OSHA PEL (Gen Indu):8H TWA 0.5 ppm (5 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 0.5 ppm (5 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 0.5 ppm (5 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 0.5 ppm (5 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 0.5 ppm (5 mg/m3);Skin JAN 1993 OEL-BELGIUM:TWA 0.5 ppm (5.2 mg/m3);Skin JAN 1993 OEL-DENMARK:TWA 0.5 ppm (5 mg/m3);Skin JAN 1993 OEL-FINLAND:TWA 0.5 ppm (5 mg/m3);STEL 1.5 ppm (15 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 0.5 ppm (5 mg/m3);Skin JAN 1993 OEL-THE NETHERLANDS:TWA 0.5 ppm (5 mg/m3);Skin JAN 1993 OEL-THE PHILIPPINES:TWA 0.5 ppm (5 mg/m3);Skin JAN 1993 OEL-RUSSIA:STEL 5 mg/m3 JAN 1993 OEL-SWITZERLAND:TWA 0.5 ppm (5 mg/m3);Skin JAN 1993 OEL-UNITED KINGDOM:TWA 0.5 ppm (5 mg/m3);Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO BROMOFORM-air:10H TWA 0.5 ppm (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 13160 No. of Facilities: 43 (estimated) No. of Industries: 3 No. of Occupations: 3 No. of Employees: 242 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 13160 No. of Facilities: 14 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1473 (estimated) No. of Female Employees: 230 (estimated)

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol	GHS02, GHS06, GHS08
Signal Word	Danger
Hazard Statements	H225-H301 + H311 + H331-H370
Precautionary Statements	P210-P260-P280-P301 + P310-P311
Personal Protective Equipment	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US)
Hazard Codes	T:Toxic
Risk Phrases	R22;R23;R36/38;R51/53
Safety Phrases	S28-S45-S61-S28A-S36/37-S16-S7
RIDADR	UN 2515 6.1/PG 3
WGK Germany	3
RTECS	PB5600000
Packaging Group	III
Hazard Class	6.1
HS Code	2903399020

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 9
CAS#:34557-54-5 methane CAS#:123-42-2 4-Hydroxy-4-met... CAS#:941-98-0 1'-Acetonaphthone CAS#:100-06-1 Acetanisole
CAS#:122-00-9 4'-Methylacetop... CAS#:563-80-4 3-Methyl-2-butanone CAS#:106053-65-0 4,5-Dimethoxy-2... CAS#:111-13-7 2-Octanone
CAS#:122-57-6 Benzalacetone
DownStream 8
CAS#:106988-87-8 4,5-dimethyl-1,... CAS#:106988-89-0 2-Methyl-endo-7... CAS#:106988-88-9 2-Methyl-exo-7-... CAS#:1070-25-3 1,1,1,3-tetrabr...
CAS#:41848-90-2 1,1-dibromo-2-h... CAS#:106988-84-5 6,6-dibromo-1-m... CAS#:1123-47-3 Cyclopropane,1,... CAS#:88919-69-1 3,4-dibromo-2,5...

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code	2903399020
Summary	2903399020 bromomethane。supervision conditions:14abxy。VAT:17.0%。tax rebate rate:0.0%。MFN tarrif:5.5%。general tariff:30.0%

This table lists relevant public references with title, journal and publication metadata for this compound.

Genotoxicity of drinking water disinfection by-products (bromoform and chloroform) by using both Allium anaphase-telophase and comet tests.

Cytotechnology 67(2) , 207-13, (2015)

Genotoxic effects of bromoform and chloroform, disinfection by-products of the chlorination of drinking water, were examined by using mitotic index (MI), mitotic phase, chromosome aberrations (CAs) an...

Formation and speciation of disinfection byproducts during chlor(am)ination of aquarium seawater.

J. Environ. Sci. (China) 33 , 116-24, (2015)

The chemistry associated with the disinfection of aquarium seawater is more complicated than that of freshwater, therefore limited information is available on the formation and speciation of disinfect...

Multisite binding of a general anesthetic to the prokaryotic pentameric Erwinia chrysanthemi ligand-gated ion channel (ELIC).

J. Biol. Chem. 288(12) , 8355-64, (2013)

Pentameric ligand-gated ion channels (pLGICs), such as nicotinic acetylcholine, glycine, γ-aminobutyric acid GABA(A/C) receptors, and the Gloeobacter violaceus ligand-gated ion channel (GLIC), are rec...

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

3-Pentanyl 2-ethylbutanoate

EINECS 200-854-6

Tribromometan

Tribrommethaan

MFCD00000128

Butanoic acid, 2-ethyl-, 1-ethylpropyl ester

tribromo methane

Tribrommethan

Bromoform

CHBr3

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the LogP of bromoform?

A: LogP of bromoform is 4.06.

Q: What is the molecular formula of bromoform?

A: Molecular formula of bromoform is CHBr3.

Q: How is the water solubility of bromoform?

A: Water solubility of bromoform: slightly soluble, 0.301 g/100 mL.

Q: What is the CAS number of bromoform?

A: CAS number of bromoform is 75-25-2.

Q: What English synonyms does bromoform have?

A: English synonyms of bromoform: 3-Pentanyl 2-ethylbutanoate, EINECS 200-854-6, Tribromometan, Tribrommethaan, MFCD00000128, Butanoic acid, 2-ethyl-, 1-ethylpropyl ester, tribromo methane, Tribrommethan, Bromoform, CHBr3.

Q: What are the upstream materials of bromoform?

A: Related upstream materials(CAS) of bromoform: 34557-54-5;123-42-2;941-98-0;100-06-1;122-00-9;563-80-4;106053-65-0;111-13-7;122-57-6.

Q: What is the safety information for bromoform?

A: Safety information for bromoform: S28-S45-S61-S28A-S36/37-S16-S7.

Q: What is the boiling point of bromoform?

A: Boiling point of bromoform is 203.9±8.0 °C at 760 mmHg.

Q: What are the downstream products of bromoform?

A: Related downstream products(CAS) of bromoform: 106988-87-8;106988-89-0;106988-88-9;1070-25-3;41848-90-2;106988-84-5;1123-47-3;88919-69-1.

Q: What is the molecular weight of bromoform?

A: Molecular weight of bromoform is 186.291.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

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