iodoform

Modify Date: 2026-07-01 11:16:57

iodoform Structure
iodoform structure
 Common Name iodoform
CAS Number 75-47-8 Molecular Weight 393.732
Density 3.9±0.1 g/cm3 Boiling Point 250.7±8.0 °C at 760 mmHg
Molecular Formula CHI3 Melting Point 119 °C
MSDS Chinese USA Flash Point 129.0±13.9 °C
Symbol GHS07
GHS07		 Signal Word Warning

 Use of iodoform


Iodoform is the organoiodine compound with the formula CHI3. A pale yellow, crystalline, volatile substance, it has a penetrating and distinctive odor (in older chemistry texts, the smell is sometimes referred to as the smell of hospitals, where the compound is still commonly used) and, analogous to chloroform, sweetish taste. It is occasionally used as a disinfectant. It is also known as tri-iodomethane, carbon triiodide, and methyl triiodide.

 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name iodoform
Synonym More Synonyms

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density 3.9±0.1 g/cm3
Boiling Point 250.7±8.0 °C at 760 mmHg
Melting Point 119 °C
Molecular Formula CHI3
Molecular Weight 393.732
Flash Point 129.0±13.9 °C
Exact Mass 393.721191
LogP 3.51
Vapour Pressure 0.0±0.5 mmHg at 25°C
Index of Refraction 1.851
InChIKey OKJPEAGHQZHRQV-UHFFFAOYSA-N
SMILES IC(I)I
Storage condition -20°C
Stability Stable. Incompatible with strong oxidizing agents, reducing agents. May explode when heated.
Water Solubility Insoluble.

 MSDS

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

 Toxicological Information

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :
PB7000000
CHEMICAL NAME :
Methane, triiodo-
CAS REGISTRY NUMBER :
75-47-8
LAST UPDATED :
199801
DATA ITEMS CITED :
34
MOLECULAR FORMULA :
C-H-I3
MOLECULAR WEIGHT :
393.72
WISWESSER LINE NOTATION :
IYII

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
355 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
165 ppm/7H
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory stimulation
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1184 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
470 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
630 mg/kg
TOXIC EFFECTS :
Behavioral - antipsychotic Vascular - other changes Lungs, Thorax, or Respiration - other changes
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
10 gm/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
450 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
487 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Amphibian - frog
DOSE/DURATION :
606 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
875 mg/kg/35D-I
TOXIC EFFECTS :
Liver - changes in liver weight Blood - changes in erythrocyte (RBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - multiple enzyme effects
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2166 mg/kg/61D-I
TOXIC EFFECTS :
Liver - other changes

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Rodent - hamster Embryo
REFERENCE :
SHIGAZ Shigaku. Ondotology. (Nippon Shika Daigaku Shigakkai, 1-9-20 Fujimi, Chiyodaku, Tokyo 102, Japan) V.38- 1949- Volume(issue)/page/year: 74,1385,1987 *** REVIEWS *** ACGIH TLV-TWA 10 mg/m3 (0.6 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 0.6 ppm (10 mg/m3) JAN 1993 OEL-BELGIUM:TWA 0.6 ppm (10 mg/m3) JAN 1993 OEL-DENMARK:TWA 0.2 ppm (3 mg/m3) JAN 1993 OEL-FINLAND:TWA 0.2 ppm (3 mg/m3);STEL 0.6 ppm (10 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 0.6 ppm (10 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 0.2 ppm (3 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 0.6 ppm (10 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 0.6 ppm (10 mg/m3);STEL 1 ppm (20 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO IODOFORM-air:10H TWA 0.6 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84474 No. of Facilities: 390 (estimated) No. of Industries: 2 No. of Occupations: 5 No. of Employees: 1882 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84474 No. of Facilities: 510 (estimated) No. of Industries: 4 No. of Occupations: 12 No. of Employees: 22584 (estimated) No. of Female Employees: 20381 (estimated)

 Safety Information

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302 + H312 + H332-H315-H319-H335
Precautionary Statements P261-P280-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes Xn:Harmful;
Risk Phrases R20/21/22;R36/37/38
Safety Phrases S26-S36/37-S36/37/39-S22
RIDADR UN 1851
WGK Germany 3
RTECS PB7000000
Hazard Class 6.1

 Synthetic Route

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

 Articles32

More Articles

This table lists relevant public references with title, journal and publication metadata for this compound.

An in vitro evaluation of antimicrobial efficacy of primary root canal filling materials.

J. Clin. Pediatr. Dent. 37(1) , 59-64, (2012)

The present study aimed to evaluate and compare six different materials commonly used for filling the root canals of primary teeth for antimicrobial efficacy against some of the microorganisms commonl...

Application of hollow fiber liquid phase microextraction for simultaneous determination of regulated and emerging iodinated trihalomethanes in drinking water.

J. Chromatogr. A. 1402 , 8-16, (2015)

Trihalomethanes (THMs) are regulated disinfection by-products (DBPs) most commonly analyzed in quality control water supply due to their harmful effects on health. However, few data exist about the co...

Inflammatory effect of green propolis on dental pulp in rats.

Braz. Oral Res. 27(5) , 417-22, (2013)

Pulpotomy in deciduous teeth is a controversial issue, especially with regard to alternative materials used for the direct pulp capping of the root canal pulp tissue. The aim of the present study was ...

 iodoformBioassay

View more

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273
Name: p53 small molecule agonists, cell-based qHTS assay: qHTS cell viability counter scree...
Source: 824
Target: N/A
External Id: P53600
Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: qHTS ce...
Source: 824
Target: N/A
External Id: P53MS958
Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: Summary
Source: 824
External Id: P53MS482
Name: p53 small molecule agonists, cell-based qHTS assay
Source: 824
External Id: P53344
Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS233
Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes: qHTS ...
Source: 824
Target: N/A
External Id: P53MS837
Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS898
Name: qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity
Source: NCGC
External Id: HERG01
Name: Adrenergic beta2 receptor (ADRB2) small molecule agonists, cell-based qHTS assay
Source: 824
External Id: ADRB2293
Total 235, Current Page 1 of 24
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 Synonyms

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

carbon triiodide
Iodoform (JP15/USP)
Iodoform
Trijodmethane [Czech]
Jodoform
CHI3
Dezinfekt V
Jodoform [Czech]
MFCD00001069
Methane,triiodo
triiodomethane
Trijod-methan
EINECS 200-874-5

 iodoform | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the CAS number of iodoform?
A: CAS number of iodoform is 75-47-8.
Q: What is the InChIKey of iodoform?
A: InChIKey of iodoform is OKJPEAGHQZHRQV-UHFFFAOYSA-N.
Q: What is the melting point of iodoform?
A: Melting point of iodoform is 119 °C.
Q: What is the molecular formula of iodoform?
A: Molecular formula of iodoform is CHI3.
Q: What are the upstream materials of iodoform?
A: Related upstream materials(CAS) of iodoform: 507-25-5;67-66-3;74-88-4;64-17-5;67-64-1;141-79-7;6819-41-6;141-52-6;109-89-7;121-44-8.
Q: What is the SMILES notation of iodoform?
A: SMILES notation of iodoform is IC(I)I.
Q: How is the water solubility of iodoform?
A: Water solubility of iodoform: Insoluble.
Q: What are the uses of iodoform?
A: Main uses of iodoform: Iodoform is the organoiodine compound with the formula CHI3. A pale yellow, crystalline, volatile substance, it has a penetrating and distinctive odor (in older chemistry texts, the smell is sometimes referred to as the smell of hospitals, where the compound is still commonly used) and, analogous to chloroform, sweetish taste. It is occasionally used as a disinfectant. It is also known as tri-iodomethane, carbon triiodide, and methyl triiodide.
Q: What are the storage conditions for iodoform?
A: Storage conditions for iodoform: -20°C.
Q: What is the English name of iodoform?
A: The English name of iodoform is iodoform.

 iodoformfactory

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd
Henan Tianfu Chemical Co., Ltd.
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Chemsrc provides iodoform(CAS#:75-47-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of iodoform are included as well.>> amp version: iodoform

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