Tetramethyl ammonium chloride

Modify Date: 2026-07-02 17:12:11

Tetramethyl ammonium chloride Structure
Tetramethyl ammonium chloride structure
 Common Name Tetramethyl ammonium chloride
CAS Number 75-57-0 Molecular Weight 109.598
Density 1,17 g/cm3 Boiling Point N/A
Molecular Formula C4H12ClN Melting Point >300 °C(lit.)
MSDS Chinese USA Flash Point N/A
Symbol GHS06 GHS08 GHS09
GHS06, GHS08, GHS09		 Signal Word Danger

 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name Tetramethyl ammonium chloride
Synonym More Synonyms

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density 1,17 g/cm3
Melting Point >300 °C(lit.)
Molecular Formula C4H12ClN
Molecular Weight 109.598
Exact Mass 109.065826
InChIKey OKIZCWYLBDKLSU-UHFFFAOYSA-M
SMILES C[N+](C)(C)C.[Cl-]
Storage condition Store at RT.
Stability Stable. Incompatible with strong oxidizing agents, water. Hygroscopic.
Water Solubility >60 g/100 mL (20 ºC)

 MSDS

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

 Toxicological Information

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :
BS7700000
CHEMICAL NAME :
Ammonium, tetramethyl-, chloride
CAS REGISTRY NUMBER :
75-57-0
LAST UPDATED :
199710
DATA ITEMS CITED :
11
MOLECULAR FORMULA :
C4-H12-N.Cl
MOLECULAR WEIGHT :
109.62
WISWESSER LINE NOTATION :
1K1&1&1 &G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
125 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 69,327,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
25 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD414-344
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
40 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: ORNL-5576
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
20 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 7,183,1900
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
6 mg/kg
TOXIC EFFECTS :
Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - other changes
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 7,183,1900
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
20 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - other changes
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 7,183,1900
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Amphibian - frog
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Cardiac - other changes
REFERENCE :
SAPHAO Skandinavisches Archiv fuer Physiologie. (Stockholm, Sweden) V.1-83, 1899-1940. For publisher information, see APSCAX. Volume(issue)/page/year: 10,201,1900 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4596 No. of Facilities: 41 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 2840 (estimated) No. of Female Employees: 1777 (estimated)

 Safety Information

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol GHS06 GHS08 GHS09
GHS06, GHS08, GHS09
Signal Word Danger
Hazard Statements H300-H311-H315-H370-H411
Precautionary Statements P260-P273-P280-P301 + P310 + P330-P302 + P352 + P312-P308 + P311
Target Organs Central nervous system
Personal Protective Equipment Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes T:Toxic
Risk Phrases R25;R36/37/38
Safety Phrases S26-S36/37-S45-S37/39-S28A-S28
RIDADR UN 2811 6.1/PG 2
WGK Germany 1
RTECS BS7700000
Packaging Group II
Hazard Class 6.1
HS Code 29239000

 Synthetic Route

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

 Customs

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code 29239000

 Articles76

More Articles

This table lists relevant public references with title, journal and publication metadata for this compound.

Sleep drives metabolite clearance from the adult brain.

Science 342(6156) , 373-7, (2013)

The conservation of sleep across all animal species suggests that sleep serves a vital function. We here report that sleep has a critical function in ensuring metabolic homeostasis. Using real-time as...

Aquaporin-4 regulates extracellular space volume dynamics during high-frequency synaptic stimulation: a gene deletion study in mouse hippocampus.

Glia 60(6) , 867-74, (2012)

Little is known about the physiological roles of aquaporin-4 (AQP4) in the central nervous system. AQP4 water channels are concentrated in endfeet membranes of astrocytes but also localize to the fine...

Extracellular quaternary ammonium blockade of transient receptor potential vanilloid subtype 1 channels expressed in Xenopus laevis oocytes.

Mol. Pharmacol. 82(6) , 1129-35, (2012)

Transient receptor potential vanilloid subtype 1 (TRPV1) channels are essential nociceptive integrators in primary afferent neurons. These nonselective cation channels are inhibited by local anestheti...

 Synonyms

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

Methanaminium, N,N,N-trimethyl-, chloride (1:1)
tetramethyl-ammonium chloride
N,N,N-Trimethylmethanaminium chloride
tetramethyl-ammoniuchloride
TMA
50g
TMACL
Tetramethylazanium chloride
tetrametylammonium chloride
MFCD00011628
tetraminechloride
EINECS 200-880-8
anhydrous tetramethylammonium chloride
Tetramethylammonium chloride
TMAC
usafan-8
Tetramethylammoniumchlorid

 Tetramethyl ammonium chloride | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the English name of Tetramethyl ammonium chloride?
A: The English name of Tetramethyl ammonium chloride is Tetramethyl ammonium chloride.
Q: What are the downstream products of Tetramethyl ammonium chloride?
A: Related downstream products(CAS) of Tetramethyl ammonium chloride: 3698-28-0;373-68-2;5111-65-9;94-30-4;1838-41-1;68628-02-4;76402-94-3;22758-12-9.
Q: What are the storage conditions for Tetramethyl ammonium chloride?
A: Storage conditions for Tetramethyl ammonium chloride: Store at RT.
Q: What is the melting point of Tetramethyl ammonium chloride?
A: Melting point of Tetramethyl ammonium chloride is >300 °C(lit.).
Q: What is the safety information for Tetramethyl ammonium chloride?
A: Safety information for Tetramethyl ammonium chloride: S26-S36/37-S45-S37/39-S28A-S28.
Q: What are the upstream materials of Tetramethyl ammonium chloride?
A: Related upstream materials(CAS) of Tetramethyl ammonium chloride: 616-38-6;593-81-7;98-09-9;75-50-3;3287-99-8;98-88-4;63581-76-0;75-59-2;1605-65-8;67-56-1.
Q: What is the molecular weight of Tetramethyl ammonium chloride?
A: Molecular weight of Tetramethyl ammonium chloride is 109.598.
Q: What is the CAS number of Tetramethyl ammonium chloride?
A: CAS number of Tetramethyl ammonium chloride is 75-57-0.
Q: What is the SMILES notation of Tetramethyl ammonium chloride?
A: SMILES notation of Tetramethyl ammonium chloride is C[N+](C)(C)C.[Cl-].
Q: What is the InChIKey of Tetramethyl ammonium chloride?
A: InChIKey of Tetramethyl ammonium chloride is OKIZCWYLBDKLSU-UHFFFAOYSA-M.

 Tetramethyl ammonium chloridefactory

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd
Dayang Chem (Hangzhou) Co., Ltd.
Henan Tianfu Chemical Co., Ltd.
Zhongshan Xingrui Chemical Co. , Ltd.
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