Fluorotrichloromethane

Modify Date: 2026-07-01 13:28:56

Fluorotrichloromethane structure	Common Name	Fluorotrichloromethane
	CAS Number	75-69-4	Molecular Weight	137.368
	Density	1.6±0.1 g/cm3	Boiling Point	26.8±8.0 °C at 760 mmHg
	Molecular Formula	CCl₃F	Melting Point	-111°C
	MSDS	Chinese USA	Flash Point	-39.3±11.9 °C
	Symbol	GHS02, GHS06, GHS08	Signal Word	Danger

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	trichlorofluoromethane
Synonym	More Synonyms

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.6±0.1 g/cm3
Boiling Point	26.8±8.0 °C at 760 mmHg
Melting Point	-111°C
Molecular Formula	CCl₃F
Molecular Weight	137.368
Flash Point	-39.3±11.9 °C
Exact Mass	135.904968
LogP	2.56
Vapour Pressure	714.0±0.1 mmHg at 25°C
Index of Refraction	1.418
InChIKey	CYRMSUTZVYGINF-UHFFFAOYSA-N
SMILES	FC(Cl)(Cl)Cl
Stability	Stable. Incompatible with bronze, silver, copper, beryllium, alkali and alkaline earth metals.
Water Solubility	insoluble. 0.124 g/100 mL

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

Fluorotrichloromethane MSDS(Chinese)

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: PB6125000

CHEMICAL NAME :: Methane, trichlorofluoro-

CAS REGISTRY NUMBER :: 75-69-4

BEILSTEIN REFERENCE NO. :: 1732469

LAST UPDATED :: 199806

DATA ITEMS CITED :: 49

MOLECULAR FORMULA :: C-Cl3-F

MOLECULAR WEIGHT :: 137.36

WISWESSER LINE NOTATION :: GXGGF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Human

DOSE/DURATION :: 50000 ppm/30M

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - conjunctive irritation Lungs, Thorax, or Respiration - fibrosing alveolitis Liver - other changes

REFERENCE :: EJTXAZ European Journal of Toxicology and Environmental Hygiene. (Paris, France) V.7-9, 1974-76. For publisher information, see TOERD9. Volume(issue)/page/year: 9,385,1976

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >352 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0520424

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 13 pph/15M

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: HUTODJ Human Toxicology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants., RG 21 2XS, UK) V.1- 1981- Volume(issue)/page/year: 1,239,1982

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10 pph/30M

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EJTXAZ European Journal of Toxicology and Environmental Hygiene. (Paris, France) V.7-9, 1974-76. For publisher information, see TOERD9. Volume(issue)/page/year: 9,385,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1743 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho University. (Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143, Japan) V.1- 1954- Volume(issue)/page/year: 18,363,1971

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 25 pph/30M

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EJTXAZ European Journal of Toxicology and Environmental Hygiene. (Paris, France) V.7-9, 1974-76. For publisher information, see TOERD9. Volume(issue)/page/year: 9,385,1976

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 25 pph/30M

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EJTXAZ European Journal of Toxicology and Environmental Hygiene. (Paris, France) V.7-9, 1974-76. For publisher information, see TOERD9. Volume(issue)/page/year: 9,385,1976 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 12000 ppm/4H/10D-I

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0571425 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-CL 5620 mg/m3 (1000 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug Research. (Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1959- Volume(issue)/page/year: 18,365,1974 TOXICOLOGY REVIEW TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 3,311,1975 TOXICOLOGY REVIEW NYSJAM New York State Journal of Medicine. (Medical Soc. of the State of New York, POB 5405, Lake Success, NY 11042) V.1- 1901- Volume(issue)/page/year: 74,1939,1974 TOXICOLOGY REVIEW AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 29,517,1968 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 MSHA STANDARD-air:TWA 1000 ppm (5600 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,118,1971 OSHA PEL (Gen Indu):8H TWA 1000 ppm (5600 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 1000 ppm (5600 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 1000 ppm (5600 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 1000 ppm (5600 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 1000 ppm (5600 mg/m3) JAN 1993 OEL-BELGIUM:STEL 1000 ppm (5620 mg/m3) JAN 1993 OEL-DENMARK:TWA 1000 ppm (5600 mg/m3) JAN 1993 OEL-FINLAND:TWA 1000 ppm (5600 mg/m3);STEL 1250 ppm (7000 mg/m3) JAN 1993 OEL-FRANCE:TWA 1000 ppm (5600 mg/m3) JAN 1993 OEL-GERMANY:TWA 1000 ppm (5600 mg/m3) JAN 1993 OEL-HUNGARY:STEL 40 mg/m3 JAN 1993 OEL-JAPAN:STEL 1000 ppm (5600 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 1000 ppm (5600 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 1000 ppm (5600 mg/m3) JAN 1993 OEL-POLAND:TWA 500 mg/m3 JAN 1993 OEL-RUSSIA:STEL 1000 ppm (1000 mg/m3) JAN 1993 OEL-SWEDEN:TWA 500 ppm (3000 mg/m3);STEL 750 ppm (4500 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 1000 ppm (5600 mg/m3) JAN 1993 OEL-TURKEY:TWA 1000 ppm (5600 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 1000 ppm (5600 mg/m3);STEL 1250 ppm JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO FLUOROTRICHLOROMETHANE-air:CL 1000 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 33565 No. of Facilities: 68187 (estimated) No. of Industries: 304 No. of Occupations: 173 No. of Employees: 785337 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 33565 No. of Facilities: 15107 (estimated) No. of Industries: 142 No. of Occupations: 119 No. of Employees: 267742 (estimated) No. of Female Employees: 95886 (estimated)

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol	GHS02, GHS06, GHS08
Signal Word	Danger
Hazard Statements	H225-H301 + H311 + H331-H370-H420
Supplemental HS	Repeated exposure may cause skin dryness or cracking.
Precautionary Statements	P210-P260-P280-P301 + P310-P311
Personal Protective Equipment	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xn:Harmful;N:Dangerousfortheenvironment;
Risk Phrases	R20;R59
Safety Phrases	S23-S24/25-S59-S61-S45-S36/37-S36-S26-S16-S24-S7
RIDADR	3082
RTECS	PB6125000
Hazard Class	5.2
HS Code	2903771000

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 10
CAS#:67-66-3 Chloroform CAS#:56-23-5 Carbon tetrachloride CAS#:75-71-8 Dichlorodifluor... CAS#:2314-97-8 Iodotrifluoromethane
CAS#:7440-09-7 Potassium CAS#:75-44-5 phosgene CAS#:7664-39-3 HYDROFLUORIC ACID CAS#:7782-50-5 Chlorine
CAS#:2154-59-8 difluoromethane CAS#:7782-41-4 Fluorine
DownStream 10
CAS#:598-88-9 1,2-DICHLORO-1,... CAS#:359-29-5 trichlorofluoro... CAS#:7782-50-5 Chlorine CAS#:421-71-6 1,1-dichloro-1-...
CAS#:358-23-6 triflic anhydride CAS#:74501-97-6 dichlorofluorom... CAS#:74501-99-8 fluoroformyl tr... CAS#:492-37-5 DL-2-Phenylprop...
CAS#:98-85-1 Methylbenzylalcohol CAS#:2510-98-7 2,3-Diphenyl-2-...

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code	2903771000

This table lists relevant public references with title, journal and publication metadata for this compound.

QSPR modeling of octanol/water partition coefficient for vitamins by optimal descriptors calculated with SMILES.

Eur. J. Med. Chem. 43 , 714-40, (2008)

Simplified molecular input line entry system (SMILES) has been utilized in constructing quantitative structure-property relationships (QSPR) for octanol/water partition coefficient of vitamins and org...

Impact of residual (18)F-fluoride in (18)F-FDOPA for the diagnosis of neuroblastoma.

Ann. Nucl. Med. 29 , 489-98, (2015)

PET imaging with (18)F-FDOPA has been successfully applied in the diagnosis and surveillance of neuroblastoma (NB) by targeting the overexpression of aromatic L-amino acid decarboxylase. This study ai...

Multiphoton dissociation/ionization of CHCl3 and CFCl3 at 355 nm: an experimental and theoretical study.

Rapid Commun. Mass Spectrom. 18(20) , 2383-7, (2004)

Nonresonant laser-induced multiphoton dissociation/ionization studies have been conducted for trichloromethane (CHCl3) and trichlorofluoromethane (CFCl3) at 355 nm, using time-of-flight mass spectrome...

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273

Name: p53 small molecule agonists, cell-based qHTS assay: qHTS cell viability counter scree...
Source: 824
Target: N/A
External Id: P53600

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: qHTS ce...
Source: 824
Target: N/A
External Id: P53MS958

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: Summary
Source: 824
External Id: P53MS482

Name: p53 small molecule agonists, cell-based qHTS assay
Source: 824
External Id: P53344

Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS233

Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes: qHTS ...
Source: 824
Target: N/A
External Id: P53MS837

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS898

Name: qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity
Source: NCGC
External Id: HERG01

Name: Adrenergic beta2 receptor (ADRB2) small molecule agonists, cell-based qHTS assay
Source: 824
External Id: ADRB2293

Total 212, Current Page 1 of 22

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

Freon 11A

Trichloromethyl fluoride

Freon 11B

GXGGF

Fluorochloroform

Trichloro(fluoro)methane

Fluorotrichloromethane

EINECS 200-892-3

Freon-11

Trichloromonofluoromethane

MFCD00000784

Trichlorofluoromethane

Monofluorotrichloromethane

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the molecular formula of trichlorofluoromethane?

A: Molecular formula of trichlorofluoromethane is CCl3F.

Q: How is the water solubility of trichlorofluoromethane?

A: Water solubility of trichlorofluoromethane: insoluble. 0.124 g/100 mL.

Q: What are the upstream materials of trichlorofluoromethane?

A: Related upstream materials(CAS) of trichlorofluoromethane: 67-66-3;56-23-5;75-71-8;2314-97-8;7440-09-7;75-44-5;7664-39-3;7782-50-5;2154-59-8;7782-41-4.

Q: What is the melting point of trichlorofluoromethane?

A: Melting point of trichlorofluoromethane is -111°C.

Q: What is the InChIKey of trichlorofluoromethane?

A: InChIKey of trichlorofluoromethane is CYRMSUTZVYGINF-UHFFFAOYSA-N.

Q: What are the downstream products of trichlorofluoromethane?

A: Related downstream products(CAS) of trichlorofluoromethane: 598-88-9;359-29-5;7782-50-5;421-71-6;358-23-6;74501-97-6;74501-99-8;492-37-5;98-85-1;2510-98-7.

Q: What is the molecular weight of trichlorofluoromethane?

A: Molecular weight of trichlorofluoromethane is 137.368.

Q: What is the boiling point of trichlorofluoromethane?

A: Boiling point of trichlorofluoromethane is 26.8±8.0 °C at 760 mmHg.

Q: What is the English name of trichlorofluoromethane?

A: The English name of trichlorofluoromethane is trichlorofluoromethane.

Q: What is the SMILES notation of trichlorofluoromethane?

A: SMILES notation of trichlorofluoromethane is FC(Cl)(Cl)Cl.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

Dayang Chem (Hangzhou) Co., Ltd.

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Fluorotrichloromethane
Price: Check
Purity: 99.5%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Trichlorofluoromethane
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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Fluorotrichloromethane

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FluorotrichloromethaneBioassay

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Fluorotrichloromethane | FAQ

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.