HEPES sodium salt

Modify Date: 2024-01-03 00:05:53

HEPES sodium salt Structure
HEPES sodium salt structure
 Common Name HEPES sodium salt
CAS Number 75277-39-3 Molecular Weight 260.286
Density N/A Boiling Point N/A
Molecular Formula C8H17N2NaO4S Melting Point 234ºC
MSDS USA Flash Point N/A

 Use of HEPES sodium salt


HEPES sodium, a nonvolatile zwitterionic chemical buffering agent, is broadly applied in cell culture. HEPES sodium is effective at pH 6.8 to 8.2. HEPES sodium is also a potent inducer of lysosome biogenesis[1][2][3].

 Names

Name sodium 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonate
Synonym More Synonyms

 HEPES sodium salt Biological Activity

Description HEPES sodium, a nonvolatile zwitterionic chemical buffering agent, is broadly applied in cell culture. HEPES sodium is effective at pH 6.8 to 8.2. HEPES sodium is also a potent inducer of lysosome biogenesis[1][2][3].
Related Catalog
In Vitro HEPES maintains superhydrophilicity of titanium for at least 3 months and resulted in a continuous retention of bioactivity and osteoconductivity[1]. HEPES drives lysosome biogenesis, affects MiT/TFE cytoplasmic-nuclear distribution, disrupts global cellular transcriptional profiles, resulting the activation of a MiT/TFE-dependent lysosomal-autophagic gene network in cultured RAW264.7 cells[3].
References

[1]. Suzuki T, et al. Nonvolatile buffer coating of titanium to prevent its biological aging and for drug delivery. Biomaterials. 2010;31(18):4818-4828.

[2]. Sledź P, et al. An experimental charge density of HEPES. Acta Crystallogr B. 2010;66(Pt 4):482-492.

[3]. https://pubmed.ncbi.nlm.nih.gov/20631430/

 Chemical & Physical Properties

Melting Point 234ºC
Molecular Formula C8H17N2NaO4S
Molecular Weight 260.286
Exact Mass 260.080658
PSA 92.29000
Storage condition Store at RT.
Stability Stable. Hygroscopic - protect from moisture. Incompatible with strong oxidizing agents.
Water Solubility H2O: 1 M at 20 °C, clear, colorless

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xn
Safety Phrases S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 29335995

 Precursor & DownStream

Precursor  2

DownStream  0

 Customs

HS Code 2933599090
Summary 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles37

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 Synonyms

1-Piperazineethanesulfonic acid, 4-(2-hydroxyethyl)-, sodium salt (1:1)
HEPES sodium salt
EINECS 278-169-7
Sodium 2-[4-(2-hydroxyethyl)-1-piperazinyl]ethanesulfonate
MFCD00036463
1-Piperazineethanesulfonic acid, 4-(2-hydroxyethyl)-, monosodium salt
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