K6PC-5

Modify Date: 2025-08-25 17:20:57

K6PC-5 structure	Common Name	K6PC-5
	CAS Number	756875-51-1	Molecular Weight	343.50100
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₉H₃₇NO₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of K6PC-5

K6PC-5, a synthetic ceramide derivative,is a direct sphingosine kinase 1(SPHK1) activator and elicites a rapid transient increase in intracellular calcium levels. K6PC-5 is used for the researches of skin diseases involving abnormal keratinocyte, neurodegeneration and virus infection[1][2][3].

Name	N-(1,3-dihydroxypropan-2-yl)-2-hexyl-3-oxodecanamide
Synonym	More Synonyms

Description	K6PC-5, a synthetic ceramide derivative,is a direct sphingosine kinase 1(SPHK1) activator and elicites a rapid transient increase in intracellular calcium levels. K6PC-5 is used for the researches of skin diseases involving abnormal keratinocyte, neurodegeneration and virus infection[1][2][3].
Related Catalog	Research Areas >> Infection Research Areas >> Neurological Disease Signaling Pathways >> Immunology/Inflammation >> SPHK
References	[1]. Kwon YB, et al. Novel synthetic ceramide derivatives increase intracellular calcium levels and promote epidermal keratinocyte differentiation. J Lipid Res. 2007 Sep;48(9):1936-43. [2]. Di Pardo A, et al. Treatment with K6PC-5, a selective stimulator of SPHK1, ameliorates intestinal homeostasis in an animal model of Huntington's disease. Neurobiol Dis. 2020 Sep;143:105009. [3]. Imre G, et al. The sphingosine kinase 1 activator, K6PC-5, attenuates Ebola virus infection. iScience. 2021 Mar 5;24(4):102266.

Description

Related Catalog

Research Areas >> Infection

Research Areas >> Neurological Disease

Signaling Pathways >> Immunology/Inflammation >> SPHK

References

[1]. Kwon YB, et al. Novel synthetic ceramide derivatives increase intracellular calcium levels and promote epidermal keratinocyte differentiation. J Lipid Res. 2007 Sep;48(9):1936-43.

[2]. Di Pardo A, et al. Treatment with K6PC-5, a selective stimulator of SPHK1, ameliorates intestinal homeostasis in an animal model of Huntington's disease. Neurobiol Dis. 2020 Sep;143:105009.

[3]. Imre G, et al. The sphingosine kinase 1 activator, K6PC-5, attenuates Ebola virus infection. iScience. 2021 Mar 5;24(4):102266.