Ethyl 5-hydroxy-2-methyl-1H-indole-3-carboxylate

Modify Date: 2025-08-27 00:15:30

Ethyl 5-hydroxy-2-methyl-1H-indole-3-carboxylate structure	Common Name	Ethyl 5-hydroxy-2-methyl-1H-indole-3-carboxylate
	CAS Number	7598-91-6	Molecular Weight	219.23700
	Density	1.282 g/cm3	Boiling Point	406.7ºC at 760 mmHg
	Molecular Formula	C₁₂H₁₃NO₃	Melting Point	205-208ºC(lit.)
	MSDS	Chinese USA	Flash Point	199.7ºC

Use of Ethyl 5-hydroxy-2-methyl-1H-indole-3-carboxylate

Ethyl 5-hydroxy-2-methyl-1H-indole-3-carboxylate is an active compound, and can be used in the synthesis of 2-phenylthiomethyl-indole derivatives, 2-phenylthiomethyl-indole derivative is a 5-lipoxygenase (5-LO) inhibitor[1].

Name	ethyl 5-hydroxy-2-methylindole-3-carboxylate
Synonym	More Synonyms

Description	Ethyl 5-hydroxy-2-methyl-1H-indole-3-carboxylate is an active compound, and can be used in the synthesis of 2-phenylthiomethyl-indole derivatives, 2-phenylthiomethyl-indole derivative is a 5-lipoxygenase (5-LO) inhibitor[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others

Density	1.282 g/cm3
Boiling Point	406.7ºC at 760 mmHg
Melting Point	205-208ºC(lit.)
Molecular Formula	C₁₂H₁₃NO₃
Molecular Weight	219.23700
Flash Point	199.7ºC
Exact Mass	219.09000
PSA	62.32000
LogP	2.35860
Index of Refraction	1.5270 (estimate)
InChIKey	BSNHKSUAAMJXBB-UHFFFAOYSA-N
SMILES	CCOC(=O)c1c(C)[nH]c2ccc(O)cc12

MSDS(Chinese)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	F+
Safety Phrases	22-24/25
RIDADR	NONH for all modes of transport
WGK Germany	3.0
HS Code	2933990090

ethyl 3-aminocr...

CAS#:41867-20-3

1,4-Benzoquinone

CAS#:106-51-4

~78%

Ethyl 5-hydroxy...

CAS#:7598-91-6

Literature: Journal of Heterocyclic Chemistry, , vol. 43, # 4 p. 873 - 879

Ethyl (2Z)-3-am...

CAS#:626-34-6

1,4-Benzoquinone

CAS#:106-51-4

~88%

Ethyl 5-hydroxy...

CAS#:7598-91-6

Literature: Research on Chemical Intermediates, , vol. 36, # 8 p. 975 - 983

Precursor 3
CAS#:41867-20-3 ethyl 3-aminocr... CAS#:106-51-4 1,4-Benzoquinone CAS#:626-34-6 Ethyl (2Z)-3-am...
DownStream 7
CAS#:23062-91-1 PD 102807 CAS#:71982-15-5 5-Hydroxy-2-met... CAS#:16052-67-8 6-BROMO-5-HYDRO... CAS#:13314-85-7 2-Methyl-1H-ind...
CAS#:32387-22-7 5-Methoxy-2-met... CAS#:50995-59-0 1H-Indole-3-car... CAS#:40963-98-2 ethyl 5-methoxy...

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Discovery of 4-amino and 4-hydroxy-1-aroylindoles as potent tubulin polymerization inhibitors.

J. Med. Chem. 51 , 4351, (2008)

1-Aroylindoline, 1-aroyl-1,2,3,4-tetrahydroquinoline, and 1-aroylindole derivatives were synthesized and evaluated for anticancer activity. The 4-amino and 4-hydroxy-1-aroylindoles 26 and 27 with IC 5...

Synthesis and pharmacology of benzoxazines as highly selective antagonists at M(4) muscarinic receptors.

J. Med. Chem. 45 , 3094, (2002)

Previously, we reported on PD 102807 (41) as being the most selective synthetic M(4) muscarinic antagonist identified to date. Synthesized analogues of 41 showed no improvement in affinity and selecti...

5-hydroxyindole-2-carboxylic acid amides: novel histamine-3 receptor inverse agonists for the treatment of obesity.

J. Med. Chem. 52 , 3855, (2009)

Obesity is a major risk factor in the development of conditions such as hypertension, hyperglycemia, dyslipidemia, coronary artery disease, and cancer. Several pieces of evidence across different spec...

Name: Primary cell-based high-throughput screening assay for identification of compounds th...
Source: Johns Hopkins Ion Channel Center
Target: regulator of G-protein signaling 4 isoform 2 [Homo sapiens]
External Id: JHICC_RGS_Act_HTS

Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

Name: QFRET-based biochemical primary high throughput screening assay to identify exosite i...
Source: The Scripps Research Institute Molecular Screening Center
Target: disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens]
External Id: ADAM17_INH_QFRET_1536_1X%INH PRUN

Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN

Name: uHTS identification of small molecule activators of the adaptive arm of the Unfolded ...
Source: Burnham Center for Chemical Genomics
Target: N/A
External Id: BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

Name: A screen for compounds that inhibit the activity of LtaS in Staphylococcus aureus
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
External Id: HMS979

Name: High throughput fluorescence intensity-based biochemical assay to screen for small mo...
Source: University of Pittsburgh Molecular Library Screening Center
Target: furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens]
External Id: MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.

Name: Fluorescence polarization to screen for inhibitor that competite the binding of FadD2...
Source: Broad Institute
Target: FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE)
External Id: 2147-01_Inhibitor_SinglePoint_HTS_Activity

Name: Primary Screen Inhibitors of CD40 Signaling in BL2 Cells Measured in Cell-Based Syste...
Source: Broad Institute
Target: N/A
External Id: 7124-01_Inhibitor_SinglePoint_HTS_Activity

Name: Dicer-mediated maturation of pre-microRNA
Source: Center for Chemical Genomics, University of Michigan
Target: N/A
External Id: TargetID_659_CEMA

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