Clathrin-IN-4

Modify Date: 2025-08-27 00:26:44

Clathrin-IN-4 Structure
Clathrin-IN-4 structure
Common Name Clathrin-IN-4
CAS Number 762242-59-1 Molecular Weight 426.15
Density N/A Boiling Point N/A
Molecular Formula C17H18Br2N2O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Clathrin-IN-4


Clathrin-IN-4 (compound 8b), a Wiskostatin (HY-12534) analogue, is a potent inhibitor of clathrin mediated endocytosis with an IC50 of 2.1 μM. Clathrin-IN-4 is a dynamin I GTPase activity inhibitor with an IC50 of 9.1 μM[1].

 Names

Name Clathrin-IN-4

 Clathrin-IN-4 Biological Activity

Description Clathrin-IN-4 (compound 8b), a Wiskostatin (HY-12534) analogue, is a potent inhibitor of clathrin mediated endocytosis with an IC50 of 2.1 μM. Clathrin-IN-4 is a dynamin I GTPase activity inhibitor with an IC50 of 9.1 μM[1].
Related Catalog
References

[1]. Peter J Cossar, et al. Wiskostatin and other carbazole scaffolds as off target inhibitors of dynamin I GTPase activity and endocytosis. Eur J Med Chem. 2022 Dec 15;247:115001.  

 Chemical & Physical Properties

Molecular Formula C17H18Br2N2O
Molecular Weight 426.15
InChIKey XUBJEDZHBUPBKL-CYBMUJFWSA-N
SMILES CN(C)CC(O)Cn1c2ccc(Br)cc2c2cc(Br)ccc21

 Clathrin-IN-4Bioassay

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Name: Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER...
Source: ChEMBL
Target: Severe acute respiratory syndrome coronavirus 2
External Id: CHEMBL4513082
Name: Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac...
Source: ChEMBL
Target: Severe acute respiratory syndrome coronavirus 2
External Id: CHEMBL4303805
Name: SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f...
Source: ChEMBL
Target: Replicase polyprotein 1ab
External Id: CHEMBL4495582
Name: Inhibition of phosphotidylserine liposome-stimulated Dynamin 1 (unknown origin) GTPas...
Source: ChEMBL
Target: Dynamin-1
External Id: CHEMBL5356087
Name: Inhibition of clathrin-mediated endocytosis in serum-starved human U2OS cells assesse...
Source: ChEMBL
Target: N/A
External Id: CHEMBL5356088
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