Kuwanon H

Modify Date: 2025-08-25 16:16:24

Kuwanon H structure	Common Name	Kuwanon H
	CAS Number	76472-87-2	Molecular Weight	760.82400
	Density	1.371g/cm3	Boiling Point	969.8ºC at 760 mmHg
	Molecular Formula	C₄₅H₄₄O₁₁	Melting Point	N/A
	MSDS	N/A	Flash Point	292.5ºC

Use of Kuwanon H

Kuwanon H is a flavonoid isolated from Morus bombycis, which acts as a potent non-peptide bombesin receptor antagonist. Kuwanon H selectively inhibits binding of gastrin releasing peptide CRP to GRP-preferring recepotr, with a Ki value of 290 nM in cells[1].

Name	kuwanone H
Synonym	More Synonyms

Description	Kuwanon H is a flavonoid isolated from Morus bombycis, which acts as a potent non-peptide bombesin receptor antagonist. Kuwanon H selectively inhibits binding of gastrin releasing peptide CRP to GRP-preferring recepotr, with a Ki value of 290 nM in cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> Bombesin Receptor
Target	Ki: 290 nM (GRP-preferring recepotr)[1]
References	[1]. Mihara S, et al. Non-peptide bombesin receptor antagonists, kuwanon G and H, isolated from mulberry. Biochem Biophys Res Commun. 1995 Aug 15;213(2):594-9.

Density	1.371g/cm3
Boiling Point	969.8ºC at 760 mmHg
Molecular Formula	C₄₅H₄₄O₁₁
Molecular Weight	760.82400
Flash Point	292.5ºC
Exact Mass	760.28800
PSA	209.12000
LogP	8.83870
Index of Refraction	1.681
InChIKey	DKBPTKFKCCNXNH-QXGWMLRCSA-N
SMILES	CC(C)=CCc1c(O)ccc(C(=O)C2C(c3c(O)cc(O)c4c(=O)c(CC=C(C)C)c(-c5ccc(O)cc5O)oc34)C=C(C)CC2c2ccc(O)cc2O)c1O
Water Solubility	Insuluble (3.5E-6 g/L) (25 ºC)