Myxothiazol structure
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Common Name | Myxothiazol | ||
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CAS Number | 76706-55-3 | Molecular Weight | 487.67800 | |
Density | 1.158g/cm3 | Boiling Point | 679.6ºC at 760 mmHg | |
Molecular Formula | C25H33N3O3S2 | Melting Point | N/A | |
MSDS | Chinese USA | Flash Point | 364.8ºC | |
Symbol |
GHS06 |
Signal Word | Danger |
Use of MyxothiazolMyxothiazol, an antifungal antibiotic, is a mitochondrial electron transport chain complex III (bc1 complex) inhibitor. Myxothiazol inhibits the growth of many yeasts and fungi at concentrations between 0.01 and 3 μg/ml[1][2]. |
Name | myxothiazol |
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Synonym | More Synonyms |
Description | Myxothiazol, an antifungal antibiotic, is a mitochondrial electron transport chain complex III (bc1 complex) inhibitor. Myxothiazol inhibits the growth of many yeasts and fungi at concentrations between 0.01 and 3 μg/ml[1][2]. |
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Related Catalog | |
In Vitro | Myxothiazol inhibits the growth of many yeasts and fungi at concentrations between 0.01 and 3 μg/ml[2]. Myxothiazol binds to the ubiquinol oxidation site Qo of complex III and blocks electron transfer from ubiquinol to cytochrome b and thus inhibits complex III activity[3]. |
In Vivo | Myxothiazol (i.p.; 0.56 mg/kg; daily for 4 days)-induced complex III inhibition can be induced in mice for four days in a row without overt hepatotoxicity or lethality[3]. Animal Model: C57Bl/J6 mice[3] Dosage: 0.56 mg/kg Administration: I.p.; 24 hours intervals for at most 4 times Result: A reversible complex III activity decrease to 50% of control value occurred at 2 h post-injection. At 74 h only minor histological changes in the liver were found, supercomplex formation was preserved and no significant changes in the expression of genes indicating hepatotoxicity or inflammation were found. |
References |
Density | 1.158g/cm3 |
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Boiling Point | 679.6ºC at 760 mmHg |
Molecular Formula | C25H33N3O3S2 |
Molecular Weight | 487.67800 |
Flash Point | 364.8ºC |
Exact Mass | 487.19600 |
PSA | 143.81000 |
LogP | 6.51870 |
Index of Refraction | 1.584 |
Storage condition | -20°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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Symbol |
GHS06 |
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Signal Word | Danger |
Hazard Statements | H300 |
Precautionary Statements | P264-P301 + P310 |
Hazard Codes | T+ |
Risk Phrases | 28 |
Safety Phrases | 28-36/37-45 |
RIDADR | UN 3462 6.1/PG 1 |
Packaging Group | III |
Hazard Class | 6.1(b) |
~59% Myxothiazol CAS#:76706-55-3 |
Literature: Iwaki, Yuki; Kaneko, Masahiro; Akita, Hiroyuki Tetrahedron Asymmetry, 2009 , vol. 20, # 3 p. 298 - 304 |
Precursor 2 | |
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DownStream 0 |
Unsuspected pyocyanin effect in yeast under anaerobiosis.
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Oxidized LDL-induced angiogenesis involves sphingosine 1-phosphate: prevention by anti-S1P antibody.
Br. J. Pharmacol. 172(1) , 106-18, (2014) Neovascularization occurring in atherosclerotic lesions may promote plaque expansion, intraplaque haemorrhage and rupture. Oxidized LDL (oxLDL) are atherogenic, but their angiogenic effect is controve... |
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The small molecule C-6 is selectively cytotoxic against breast cancer cells and its biological action is characterized by mitochondrial defects and endoplasmic reticulum stress.
Breast Cancer Res. 16(6) , 472, (2015) The establishment of drug resistance following treatment with chemotherapeutics is strongly associated with poor clinical outcome in patients, and drugs that target chemoresistant tumors have the pote... |
2,6-Heptadienamide,7-(2'-((1S,2E,4E)-1,6-dimethyl-2,4-heptadienyl)(2,4'-bithiazol)-4-yl)-3,5-dimethoxy-4-methyl-,(2E,4R,5S,6E) |
MFCD00043397 |
MYXOTHIAZOL |
7-(2 |
5-dimethoxy-4-methyl |
2,6-Heptadienamide,7-(2'-(1,6-dimethyl-2,4-heptadienyl)(2,4'-bithiazol)-4-yl)-3,5-dimethoxy-4-methyl |