7-Diethylamino-3-[4-(iodoacetamido)phenyl]-4-methylcoumarin

Modify Date: 2024-01-05 11:13:12

7-Diethylamino-3-[4-(iodoacetamido)phenyl]-4-methylcoumarin Structure
7-Diethylamino-3-[4-(iodoacetamido)phenyl]-4-methylcoumarin structure
Common Name 7-Diethylamino-3-[4-(iodoacetamido)phenyl]-4-methylcoumarin
CAS Number 76877-34-4 Molecular Weight 490.33400
Density 1.531g/cm3 Boiling Point 658.2ºC at 760 mmHg
Molecular Formula C22H23IN2O3 Melting Point N/A
MSDS USA Flash Point 351.9ºC
Symbol GHS06
GHS06
Signal Word Danger

 Use of 7-Diethylamino-3-[4-(iodoacetamido)phenyl]-4-methylcoumarin


DCIA is a fluorescent dye. DCIA contains a coumarin fluorophore and conjugates specifically with free cysteines in the protein[1].

 Names

Name N-[4-[7-(diethylamino)-4-methyl-2-oxochromen-3-yl]phenyl]-2-iodoacetamide
Synonym More Synonyms

  Biological Activity

Description DCIA is a fluorescent dye. DCIA contains a coumarin fluorophore and conjugates specifically with free cysteines in the protein[1].
Related Catalog
References

[1]. Branigan E, et al. Quantification of free cysteines in membrane and soluble proteins using a fluorescent dye and thermal unfolding. Nat Protoc. 2013 Nov;8(11):2090-7.

 Chemical & Physical Properties

Density 1.531g/cm3
Boiling Point 658.2ºC at 760 mmHg
Molecular Formula C22H23IN2O3
Molecular Weight 490.33400
Flash Point 351.9ºC
Exact Mass 490.07500
PSA 62.55000
LogP 5.06110
Index of Refraction 1.67

 Safety Information

Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H301-H413
Precautionary Statements P301 + P310
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves
RIDADR UN 2811 6.1 / PGIII
HS Code 2932209090

 Customs

HS Code 2932209090
Summary 2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles4

More Articles
High-performance liquid chromatography with chemiluminescence detection of serum levels of pre-column derivatized fluoropyrimidine compounds.

J. Chromatogr. A. 530(1) , 57-64, (1990)

7-(Diethylamino)-3-[4-[iodoacetyl)amino)phenyl]-4-methylcoumarin (DCIA) and 4-(bromomethyl)-7-methoxycoumarin have been evaluated as fluoropyrimidine-derivatizing agents to be detected using peroxyoxa...

Fluorescence characterization of the environment encountered by nascent polyalanine and polyserine as they exit Escherichia coli ribosomes during translation.

Biochemistry 31(8) , 2368-75, (1992)

The fate of the amino termini of nascent polyalanine, polyserine, and polylysine was monitored by fluorescence techniques as each was translated on Escherichia coli ribosomes. A coumarin probe was pla...

New fluorochromes for thiols: maleimide and iodoacetamide derivatives of a 3-phenylcoumarin fluorophore.

J. Histochem. Cytochem. 29(2) , 314-6, (1981)

N-(4-(7 - Diethylamino - methylcoumarin - 3 yl)phenyl)maleimide (CPM) and the corresponding iodoacetamide are described. When applied to sections at pH 6 and 9, respectively, the two fluorogens are ve...

 Synonyms

n-{4-[7-(diethylamino)-4-methyl-2-oxo-2h-chromen-3-yl]phenyl}-2-iodoacetamide
Demcpi
7-DIETHYLAMINO-3-[4-(IODOACETAMIDO)PHENYL]-4-METHYLCOUMARIN
DCIA
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