4-Chloro-1,5-naphthyridine

Modify Date: 2024-01-05 15:14:58

4-Chloro-1,5-naphthyridine Structure
4-Chloro-1,5-naphthyridine structure
Common Name 4-Chloro-1,5-naphthyridine
CAS Number 7689-63-6 Molecular Weight 164.592
Density 1.4±0.1 g/cm3 Boiling Point 269.2±20.0 °C at 760 mmHg
Molecular Formula C8H5ClN2 Melting Point 102-103ºC
MSDS N/A Flash Point 142.5±7.4 °C

 Names

Name 4-Chloro-1,5-naphthyridine
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 269.2±20.0 °C at 760 mmHg
Melting Point 102-103ºC
Molecular Formula C8H5ClN2
Molecular Weight 164.592
Flash Point 142.5±7.4 °C
Exact Mass 164.014130
PSA 25.78000
LogP 0.89
Vapour Pressure 0.0±0.5 mmHg at 25°C
Index of Refraction 1.663
Storage condition 2-8°C

 Safety Information

Hazard Codes Xi
HS Code 2933990090

 Synthetic Route

~61%

4-Chloro-1,5-naphthyridine Structure

4-Chloro-1,5-na...

CAS#:7689-63-6

Literature: Sieb, David; Schuhen, Katrin; Morgen, Michael; Herrmann, Heike; Wadepohl, Hubert; Lucas, Nigel T.; Baker, Robert W.; Enders, Markus Organometallics, 2012 , vol. 31, # 1 p. 356 - 364

~40%

4-Chloro-1,5-naphthyridine Structure

4-Chloro-1,5-na...

CAS#:7689-63-6

Literature: Nishimura, Nobuko; Siegmund, Aaron; Liu, Longbin; Yang, Kevin; Bryan, Marian C.; Andrews, Kristin L.; Bo, Yunxin; Booker, Shon K.; Caenepeel, Sean; Freeman, Daniel; Liao, Hongyu; McCarter, John; Mullady, Erin L.; San Miguel, Tisha; Subramanian, Raju; Tamayo, Nuria; Wang, Ling; Whittington, Douglas A.; Zalameda, Leeanne; Zhang, Nancy; Hughes, Paul E.; Norman, Mark H. Journal of Medicinal Chemistry, 2011 , vol. 54, # 13 p. 4735 - 4751

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4-Chloro-1,5-naphthyridine Structure

4-Chloro-1,5-na...

CAS#:7689-63-6

Literature: Adams et al. Journal of the American Chemical Society, 1946 , vol. 68, p. 1317

~36%

4-Chloro-1,5-naphthyridine Structure

4-Chloro-1,5-na...

CAS#:7689-63-6

Literature: VIFOR (INTERNATIONAL) AG Patent: US2012/214803 A1, 2012 ; Location in patent: Page/Page column 174 ; US 20120214803 A1

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4-Chloro-1,5-naphthyridine Structure

4-Chloro-1,5-na...

CAS#:7689-63-6

Literature: VIFOR (INTERNATIONAL) AG Patent: US2012/214803 A1, 2012 ; US 20120214803 A1

~%

4-Chloro-1,5-naphthyridine Structure

4-Chloro-1,5-na...

CAS#:7689-63-6

Literature: Nishimura, Nobuko; Siegmund, Aaron; Liu, Longbin; Yang, Kevin; Bryan, Marian C.; Andrews, Kristin L.; Bo, Yunxin; Booker, Shon K.; Caenepeel, Sean; Freeman, Daniel; Liao, Hongyu; McCarter, John; Mullady, Erin L.; San Miguel, Tisha; Subramanian, Raju; Tamayo, Nuria; Wang, Ling; Whittington, Douglas A.; Zalameda, Leeanne; Zhang, Nancy; Hughes, Paul E.; Norman, Mark H. Journal of Medicinal Chemistry, 2011 , vol. 54, # 13 p. 4735 - 4751

~%

4-Chloro-1,5-naphthyridine Structure

4-Chloro-1,5-na...

CAS#:7689-63-6

Literature: INFINITY PHARMACEUTICALS INC.; INTELLIKINE, LLC; CASTRO, Alfredo, C.; EVANS, Catherine, A.; JANARDANANNAIR, Somarajannair; LESCARBEAU, Andre; LIU, Tao; SNYDER, Daniel, A.; TREMBLAY, Martin, R.; REN, Pingda; LIU, Yi; LI, Liansheng; CHAN, Katrina Patent: WO2013/12915 A1, 2013 ; WO 2013/012915 A1

~%

4-Chloro-1,5-naphthyridine Structure

4-Chloro-1,5-na...

CAS#:7689-63-6

Literature: INFINITY PHARMACEUTICALS INC.; INTELLIKINE, LLC; CASTRO, Alfredo, C.; EVANS, Catherine, A.; JANARDANANNAIR, Somarajannair; LESCARBEAU, Andre; LIU, Tao; SNYDER, Daniel, A.; TREMBLAY, Martin, R.; REN, Pingda; LIU, Yi; LI, Liansheng; CHAN, Katrina Patent: WO2013/12915 A1, 2013 ; WO 2013/012915 A1

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

4-chloro-[1,5]naphthyridine
1,5-Naphthyridine, 4-chloro-
4-chloranyl-1,5-naphthyridine
4-Chloro-1,5-naphthyridine
4-Chlor-1,5-naphtyridin
8-chloro-1,5-naphthyridine
4-Chlor-1,5-naphthyridin