ML406
Modify Date: 2024-01-13 15:25:07
ML406 structure
|
Common Name | ML406 | ||
|---|---|---|---|---|
| CAS Number | 774589-47-8 | Molecular Weight | 352.384 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 596.0±50.0 °C at 760 mmHg | |
| Molecular Formula | C20H20N2O4 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 314.2±30.1 °C | |
| Symbol |
GHS09 |
Signal Word | Warning | |
Use of ML406ML406 is a small molecule probe that shows anti-tubercular activity via MtbbioA (DAPA synthase) enzyme inhibition with an IC50 of 30 nM[1]. |
| Name | 1-{4-[4-(1,3-Benzodioxol-5-ylcarbonyl)-1-piperazinyl]phenyl}ethanone |
|---|---|
| Synonym | More Synonyms |
| Description | ML406 is a small molecule probe that shows anti-tubercular activity via MtbbioA (DAPA synthase) enzyme inhibition with an IC50 of 30 nM[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50 30 nM (BioA)[1] |
| In Vitro | ML406 inhibits WT Mycobacterium tuberculosis (Mtb) (H37Rv) growth inhibition with the IC50 of 3.2 μM. BioA is an enzyme involved in biotin biosynthesis in Mtb that may serve as lead compounds for drug development for tuberculosis (TB)[1]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 596.0±50.0 °C at 760 mmHg |
| Molecular Formula | C20H20N2O4 |
| Molecular Weight | 352.384 |
| Flash Point | 314.2±30.1 °C |
| Exact Mass | 352.142303 |
| LogP | 0.82 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.621 |
| Symbol |
GHS09 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H410 |
| Precautionary Statements | P273-P391-P501 |
| RIDADR | UN 3077 9 / PGIII |
| Ethanone, 1-[4-[4-(1,3-benzodioxol-5-ylcarbonyl)-1-piperazinyl]phenyl]- |
| 1-{4-[4-(1,3-Benzodioxol-5-ylcarbonyl)-1-piperazinyl]phenyl}ethanone |
| 1-{4-[4-(1,3-benzodioxol-5-ylcarbonyl)piperazin-1-yl]phenyl}ethanone |
| MFCD06004413 |