Pipequaline

Modify Date: 2024-01-08 15:40:54

Pipequaline Structure
Pipequaline structure
Common Name Pipequaline
CAS Number 77472-98-1 Molecular Weight 316.43900
Density 1.078g/cm3 Boiling Point 489.2ºC at 760 mmHg
Molecular Formula C22H24N2 Melting Point N/A
MSDS N/A Flash Point 249.7ºC

 Use of Pipequaline


Pipequaline (PK 8165) is a non-selective GABAA receptor partial agonist with anxiolytic activity.

 Names

Name 2-phenyl-4-(2-piperidin-4-ylethyl)quinoline
Synonym More Synonyms

 Pipequaline Biological Activity

Description Pipequaline (PK 8165) is a non-selective GABAA receptor partial agonist with anxiolytic activity.
Related Catalog
In Vitro Pipequaline is extensively bound to plasma proteins: i.e. human serum albumin (HSA), alpha-1-acid glycoprotein (AAG), lipoproteins and blood cells, mainly erythrocytes[1].
In Vivo Intravenously administered pipequaline exerts a partial suppression of activations by kainate, glutamate and acetylcholine. Microiontophoretic applications of pipequaline reduces the neuronal activation by kainate[2]. Pipequaline produces dose-related decreases in motor activity. Pipequaline produces significant dose-related decreases in the number of head-dips made[3].
Animal Admin Rats: Pipequaline is dissolved in water to give injection volumes of 2 mL/kg. Rats are injected with 5, 10, and 50 mg/kg pipequaline. Infrared cells in the walls of the box provided automated measures of locomotor activity and rearing, respectively[3].
References

[1]. Essassi D, et al. Pipequaline transport from blood to brain and liver: role of plasma protein-bound drug. J Pharm Pharmacol. 1989 Sep;41(9):595-600.

[2]. Debonnel G, et al. Pipequaline acts as a partial agonist of benzodiazepine receptors: an electrophysiological study in the hippocampus of the rat. Neuropharmacology. 1987 Sep;26(9):1337-42.

[3]. File SE., et al. Sedative effects of PK 9084 and PK 8165, alone and in combination with chlordiazepoxide. Br J Pharmacol. 1983 May;79(1):219-23.

 Chemical & Physical Properties

Density 1.078g/cm3
Boiling Point 489.2ºC at 760 mmHg
Molecular Formula C22H24N2
Molecular Weight 316.43900
Flash Point 249.7ºC
Exact Mass 316.19400
PSA 24.92000
LogP 5.16280
Index of Refraction 1.602
Storage condition 2-8℃

 Synonyms

Pipequalina
Pipequalina [Spanish]
Pipequalinum [Latin]
Quinoline,2-phenyl-4-(2-(4-piperidinyl)ethyl)
2-Phenyl-4-(2-(4-piperidyl)ethyl)quinoline
2-phenyl-4-[2-(piperidin-4-yl)ethyl]quinoline
Pipequalinum
PK-8165
Pipequaline
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