2-Guanidinoethylmercaptosuccinic Acid
Modify Date: 2024-01-11 09:55:29
2-Guanidinoethylmercaptosuccinic Acid structure
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Common Name | 2-Guanidinoethylmercaptosuccinic Acid | ||
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| CAS Number | 77482-44-1 | Molecular Weight | 235.26100 | |
| Density | 1.59g/cm3 | Boiling Point | 452.9ºC at 760 mmHg | |
| Molecular Formula | C7H13N3O4S | Melting Point | -180ºC (dec.) | |
| MSDS | N/A | Flash Point | 227.7ºC | |
Use of 2-Guanidinoethylmercaptosuccinic AcidGEMSA is a potent inhibitor of enkephalin convertase (Ki=8.8 nM). GEMSA elicites analgesia[1]. |
| Name | 2-[2-(diaminomethylideneamino)ethylsulfanyl]butanedioic acid |
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| Synonym | More Synonyms |
| Description | GEMSA is a potent inhibitor of enkephalin convertase (Ki=8.8 nM). GEMSA elicites analgesia[1]. |
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| Related Catalog | |
| Target |
Encephalin convertase, Ki 值为8.8 nM. |
| In Vitro | GEMSA inhibits the activation of TAFI and porcine CBB[1]. GEMSA can inhibit the prolongation of lysis time in recombinant BAP and does not lead to the lysis of APC fibronectin[1]. GEMSA inhibits the prolongation of lysis time in porcine CPB, TAFI, and recombinant BAP, APC with the EC50 values of 0.34 μM, 100μM, 115 μM, 90 μM respectively[1][2]. |
| In Vivo | GEMSA (ICV, 0.1μg/mg, every, 3days) results in a 75% increase in hypothalamic luteinizing hormone-releasing hormone and serum luteinizing hormone levels, and a 60% decrease in serum prolactin concentrations in rat[3] |
| References |
| Density | 1.59g/cm3 |
|---|---|
| Boiling Point | 452.9ºC at 760 mmHg |
| Melting Point | -180ºC (dec.) |
| Molecular Formula | C7H13N3O4S |
| Molecular Weight | 235.26100 |
| Flash Point | 227.7ºC |
| Exact Mass | 235.06300 |
| PSA | 161.80000 |
| LogP | 0.32150 |
| Index of Refraction | 1.637 |
| HS Code | 2930909090 |
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| Summary | 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
| (2-guanidinoethylmercapto)succinic |
| DL-guanidinoethylmercaptosuccinic acid |
| 2-(2-guanidinoethylthio) succinic acid |
| 2-guanidinoethylmercaptosuccinic acid |
| gemsa |
| 2-[(2-carbamimidamidoethyl)sulfanyl]succinic acid |
| Guanidinoethyl-Mercaptosuccinic Acid |