Isoscopoletin
Isoscopoletin structure
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Common Name | Isoscopoletin | ||
|---|---|---|---|---|
| CAS Number | 776-86-3 | Molecular Weight | 192.168 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 413.5±45.0 °C at 760 mmHg | |
| Molecular Formula | C10H8O4 | Melting Point | 206-208ºC | |
| MSDS | N/A | Flash Point | 172.4±22.2 °C | |
Use of IsoscopoletinIsoscopoletin (6-Hydroxy-7-methoxycoumarin) is an active constituent in Artemisia argyi leaves. Isoscopoletin shows substantial inhibition against cell proliferation, with IC50s of 4.0 μM and 1.6 μM for human CCRF-CEM leukaemia cells and multidrug resistant subline CEM/ADR5000, respectively[1]. Isoscopoletin (6-Hydroxy-7-methoxycoumarin) possesses inhibitory activity against HBV replication[2]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | 6-Hydroxy-7-methoxy-2H-chromen-2-one |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Isoscopoletin (6-Hydroxy-7-methoxycoumarin) is an active constituent in Artemisia argyi leaves. Isoscopoletin shows substantial inhibition against cell proliferation, with IC50s of 4.0 μM and 1.6 μM for human CCRF-CEM leukaemia cells and multidrug resistant subline CEM/ADR5000, respectively[1]. Isoscopoletin (6-Hydroxy-7-methoxycoumarin) possesses inhibitory activity against HBV replication[2]. |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 413.5±45.0 °C at 760 mmHg |
| Melting Point | 206-208ºC |
| Molecular Formula | C10H8O4 |
| Molecular Weight | 192.168 |
| Flash Point | 172.4±22.2 °C |
| Exact Mass | 192.042252 |
| PSA | 59.67000 |
| LogP | 0.83 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.609 |
| InChIKey | SYTYLPHCLSSCOJ-UHFFFAOYSA-N |
| SMILES | COc1cc2oc(=O)ccc2cc1O |
| Storage condition | 2-8°C |
| Water Solubility | DMSO: soluble |
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Hazard Codes | Xi |
|---|---|
| Risk Phrases | R22 |
| Safety Phrases | S22-24/25-36-26 |
| WGK Germany | 3 |
| HS Code | 29322090 |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| 7-Methoxyesculetin |
| iso-Scopoletin |
| 6-Hydroxy-7-methoxy-2H-chromen-2-one |
| 6-hydroxy-7-methoxychromen-2-one |
| Isoscopoletin |
| EINECS 212-282-4 |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the CAS number of 6-Hydroxy-7-methoxy-2H-chromen-2-one? |
| A: CAS number of 6-Hydroxy-7-methoxy-2H-chromen-2-one is 776-86-3. |
| Q: What is the safety information for 6-Hydroxy-7-methoxy-2H-chromen-2-one? |
| A: Safety information for 6-Hydroxy-7-methoxy-2H-chromen-2-one: S22-24/25-36-26. |
| Q: What is the polar surface area (PSA) of 6-Hydroxy-7-methoxy-2H-chromen-2-one? |
| A: Polar surface area (PSA) of 6-Hydroxy-7-methoxy-2H-chromen-2-one is 59.67000. |
| Q: What is the boiling point of 6-Hydroxy-7-methoxy-2H-chromen-2-one? |
| A: Boiling point of 6-Hydroxy-7-methoxy-2H-chromen-2-one is 413.5±45.0 °C at 760 mmHg. |
| Q: What is the InChIKey of 6-Hydroxy-7-methoxy-2H-chromen-2-one? |
| A: InChIKey of 6-Hydroxy-7-methoxy-2H-chromen-2-one is SYTYLPHCLSSCOJ-UHFFFAOYSA-N. |
| Q: What are the uses of 6-Hydroxy-7-methoxy-2H-chromen-2-one? |
| A: Main uses of 6-Hydroxy-7-methoxy-2H-chromen-2-one: Isoscopoletin (6-Hydroxy-7-methoxycoumarin) is an active constituent in Artemisia argyi leaves. Isoscopoletin shows substantial inhibition against cell proliferation, with IC50s of 4.0 μM and 1.6 μM for human CCRF-CEM leukaemia cells and multidrug resistant subline CEM/ADR5000, respectively[1]. Isoscopoletin (6-Hydroxy-7-methoxycoumarin) possesses inhibitory activity against HBV replication[2]. |
| Q: What is the molecular weight of 6-Hydroxy-7-methoxy-2H-chromen-2-one? |
| A: Molecular weight of 6-Hydroxy-7-methoxy-2H-chromen-2-one is 192.168. |
| Q: What is the English name of 6-Hydroxy-7-methoxy-2H-chromen-2-one? |
| A: The English name of 6-Hydroxy-7-methoxy-2H-chromen-2-one is 6-Hydroxy-7-methoxy-2H-chromen-2-one. |
| Q: What English synonyms does 6-Hydroxy-7-methoxy-2H-chromen-2-one have? |
| A: English synonyms of 6-Hydroxy-7-methoxy-2H-chromen-2-one: 7-Methoxyesculetin, iso-Scopoletin, 6-Hydroxy-7-methoxy-2H-chromen-2-one, 6-hydroxy-7-methoxychromen-2-one, Isoscopoletin, EINECS 212-282-4. |
| Q: What is the molecular formula of 6-Hydroxy-7-methoxy-2H-chromen-2-one? |
| A: Molecular formula of 6-Hydroxy-7-methoxy-2H-chromen-2-one is C10H8O4. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| BioBioPha |
| Dayang Chem (Hangzhou) Co., Ltd. |
| naturewill |