Picoprazole
Modify Date: 2024-01-11 19:02:14
Picoprazole structure
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Common Name | Picoprazole | ||
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| CAS Number | 78090-11-6 | Molecular Weight | 343.40000 | |
| Density | 1.41g/cm3 | Boiling Point | 597.1ºC at 760 mmHg | |
| Molecular Formula | C17H17N3O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 314.9ºC | |
Use of PicoprazolePicoprazole is a specific inhibitor of H+/K+-ATPase with IC50 of 3.1±0.4 μM. |
| Name | methyl 6-methyl-2-[(3-methylpyridin-2-yl)methylsulfinyl]-1H-benzimidazole-5-carboxylate |
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| Synonym | More Synonyms |
| Description | Picoprazole is a specific inhibitor of H+/K+-ATPase with IC50 of 3.1±0.4 μM. |
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| Related Catalog | |
| Target |
IC50: 3.1±0.4 μM (H+/K+-ATPase)[1] |
| In Vitro | Picoprazole inhibits the H+/K+-ATPase activity in a concentration-dependent manner. The IC50 value is 3.1±0.4 μM[1]. Picoprazole is a specific inhibitor of H+/K+-ATPase and binds to 100-kDa polypeptides of the enzyme, dose dependently inhibited opening of the Cl- conductance by Cu2+-o-phenanthroline, indicating that the Cl- conductance is part of the function of the H+/K+-ATPase[2]. The inhibitory effect of the three benzimidazole derivatives Timoprazole, Picoprazole, and Omeprazole on histamine and dbcAMP stimulated 14C-aminopyrine accumulation (H+ secretion) has been studied in isolated and enriched guinea-pig parietal cells. All compounds tested inhibit H+ secretion in a concentration dependent manner with IC50 values of 8.5±1.9 μM for Timoprazole, 3.9±0.7 μM for Picoprazole, and 0.13±0.03 μM for Omeprazole[3]. |
| References |
| Density | 1.41g/cm3 |
|---|---|
| Boiling Point | 597.1ºC at 760 mmHg |
| Molecular Formula | C17H17N3O3S |
| Molecular Weight | 343.40000 |
| Flash Point | 314.9ºC |
| Exact Mass | 343.09900 |
| PSA | 104.15000 |
| LogP | 3.53480 |
| Index of Refraction | 1.684 |
| Storage condition | 2-8℃ |
| Picoprazolum |
| methyl 6-methyl-2-[[(3-methyl-2-pyridyl)methyl]sulfinyl]-5-benzimidazolecarboxylate |
| Picoprazol |
| Picoprazole |
| Picoprazole (INN) |