Diclofenac diethylammonium salt

Modify Date: 2025-08-23 08:14:29

Diclofenac diethylammonium salt Structure
Diclofenac diethylammonium salt structure
Common Name Diclofenac diethylammonium salt
CAS Number 78213-16-8 Molecular Weight 369.285
Density N/A Boiling Point 412ºC at 760 mmHg
Molecular Formula C18H22Cl2N2O2 Melting Point 145-148ºC
MSDS N/A Flash Point 203ºC

 Use of Diclofenac diethylammonium salt


Diclofenac diethylamine is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 nM, 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1, 0.84 μM for ovine COX-1 and COX-2, respectively.

 Names

Name Diclofenac diethylamine
Synonym More Synonyms

 Diclofenac diethylammonium salt Biological Activity

Description Diclofenac diethylamine is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 nM, 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1, 0.84 μM for ovine COX-1 and COX-2, respectively.
Related Catalog
Target

Human COX-2:1.3 nM (IC50, in CHO cells)

Human COX-1:4 nM (IC50, in CHO cells)

Ovine COX-2:0.84 μM (IC50)

Ovine COX-1:5.1 μM (IC50)

In Vitro Diclofenac diethylamine is a potent COX inhibitor, with IC50s of 4 nM and 1.3 nM for human COX-1 and COX-2 in the CHO cells, respectively. Diclofenac effectively blocks COX-1 mediated prostanoid production from U937 cell microsomes, with an IC50 of 7 ± 3 nM[1]. Diclofenac sodium exihibits inhibition on COX-1 and COX-2 enzyme with IC50s of 5.1 and 0.84 μM, respectively[2].
In Vivo Diclofenac (3 mg/kg, b.i.d., for 5 days) significantly increases faecal 51Cr excretion in rats, and such effect is also observed in squirrel monkeys after administrated of 1 mg/kg twice daily for 4 days[1]. Diclofenac (10 mg/kg) shows anti-inflammatory activity in mice[2]. Diclofenac (10 mg/kg) decreases oxidized low-densitylipoprotein (Ox-LDL), but shows no effects on the kinetics parameters of catalase and glutathione peroxidase via intramuscularly injection into rats[3].
Animal Admin Rats[1] Male Sprague-Dawley rats (150 ± 200 g) are dosed orally with Diclofenac either once (acute dosing) or twice daily for 5 days (chronic dosing). A plasma sample is obtained 1 h after the morning dose on day 4 for measurement of Diclofenac concentration. Immediately after the administration of the last dose on day 5, the rats are injected via a tail vein with 0.5 mL of 51Cr-labelled red blood cells from a donor rat after incubation with sodium 51chromate. The rats are placed individually in metabolism cages with food and water ad libitum. Faeces are collected for a 48 h period and 51Cr faecal excretion is calculated as a % of total injected dose (20 mCi per animal)[1]. Squirrel monkeys[1] Squirrel monkeys (Saimiri sciureus; 0.8 ± 1.4 kg) are dosed orally with Diclofenac twice daily for 1 ± 5 days. One hour after administration of the last dose, 51CrCl3 in sterile saline (1 mL/kg, 4 ± 5 mCi per animal) is injected via a saphenous vein and plasma samples are obtained for measurement of Diclofenac concentration. The monkeys are then housed individually in metabolism cages. Faeces are collected for a 24 h period and 51Cr faecal excretion is calculated as a % of total injected dose[1].
References

[1]. Riendeau D, et al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br J Pharmacol. 1997 May;121(1):105-17.

[2]. Labib MB, et al. Design, synthesis of novel isoindoline hybrids as COX-2 inhibitors: Anti-inflammatory, analgesic activities and docking study. Bioorg Chem. 2018 Oct;80:70-80.

[3]. Curcelli EC, et al. Beneficial effects of diclofenac therapy on serum lipids, oxidized low-density lipoprotein and antioxidant defenses in rats. Life Sci. 2008 Apr 9;82(15-16):892-8.

 Chemical & Physical Properties

Boiling Point 412ºC at 760 mmHg
Melting Point 145-148ºC
Molecular Formula C18H22Cl2N2O2
Molecular Weight 369.285
Flash Point 203ºC
Exact Mass 368.105835
PSA 61.36000
LogP 5.44380

 Safety Information

HS Code 2942000000

 Customs

HS Code 2942000000

 Synonyms

N-ethylethanaminium {2-[(2,6-dichlorophenyl)amino]phenyl}acetate
Diclofenac diethylamine
n-ethylethanamine 2-[(2,6-dichlorophenyl)amino]benzeneacetate
UNII-6TGQ35Z71K
2-[(2,6-dichlorophenyl)amino]-benzeneacetic acid compd. with n-ethylethanamine (1:1)
2-[(2,6-dichlorophenyl)amino]-benzeneacetic acid compd. with n-ethylethanamine
Diclofenac (diethylamine)
MFCD01862249
Voltarol
{2-[(2,6-Dichlorophenyl)amino]phenyl}acetic acid - N-ethylethanamine (1:1)
Benzeneacetic acid, 2-[(2,6-dichlorophenyl)amino]-, compd. with N-ethylethanamine (1:1)
2-[2-(2,6-dichloroanilino)phenyl]acetic acid
Diclofenac diethylammonium salt
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.
Top Suppliers:I want be here



Get all suppliers and price by the below link:

Diclofenac diethylammonium salt suppliers


Price: $62/5g

Reference only. check more Diclofenac diethylammonium salt price