Dermorphin TFA
Modify Date: 2024-01-09 21:16:51
Dermorphin TFA structure
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Common Name | Dermorphin TFA | ||
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| CAS Number | 78331-26-7 | Molecular Weight | 916.89600 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C42H51F3N8O12 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Dermorphin TFADermorphin TFA is a natural heptapeptide μ-opioid receptor (MOR) agonist found in amphibian skin. Inhibition of neuropathic pain[1]. |
| Name | (S)-1-(L-tyrosyl-D-alanyl-L-phenylalanylglycyl-L-tyrosyl)-N-((S)-1-amino-3-hydroxy-1-oxopropan-2-yl)pyrrolidine-2-carboxamide 2,2,2-trifluoroacetate |
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| Description | Dermorphin TFA is a natural heptapeptide μ-opioid receptor (MOR) agonist found in amphibian skin. Inhibition of neuropathic pain[1]. |
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| Related Catalog | |
| Target |
μ-opioid receptor (MOR)[1] |
| In Vitro | Dermorphin, a peptide isolated from the skin of Phyllomedusa frogs and the peptide receptor (NOP) component by the endogenous agonist nociceptin/orphanin FQ (N/OFQ). In displacement binding studies at CHOhMu, Dermorphin and DeNo displac the binding of [3H]-DPN in a concentration dependent and saturable manner. Dermorphin displays an affinity of 7.17, while N/OFQ fails to displace [3H]-DPN at the Delta receptor. Dermorphin and DeNo stimulate the binding of GTPγ[35S] in a concentration dependent and saturable manner at the Mu receptor[2]. |
| References |
| Molecular Formula | C42H51F3N8O12 |
|---|---|
| Molecular Weight | 916.89600 |
| Exact Mass | 916.35800 |
| PSA | 332.91000 |
| LogP | 1.92320 |