Diazolidinyl urea

Modify Date: 2025-09-29 07:33:01

Diazolidinyl urea Structure
Diazolidinyl urea structure
 Common Name Diazolidinyl urea
CAS Number 78491-02-8 Molecular Weight 278.219
Density 1.8±0.1 g/cm3 Boiling Point 421.04°C (rough estimate)
Molecular Formula C8H14N4O7 Melting Point N/A
MSDS Chinese USA Flash Point N/A
Symbol GHS07
GHS07		 Signal Word Warning

 Use of Diazolidinyl urea


Diazolidinyl urea, a broad spectrum preservative, is a formaldehyde-releasing compound that releases formaldehyde through its decomposition. Diazolidinyl urea is effective against most contaminating microorganisms, especially Pseudomonas[1][2].

 Names

Name Diazolidinyl urea
Synonym More Synonyms

 Diazolidinyl urea Biological Activity

Description Diazolidinyl urea, a broad spectrum preservative, is a formaldehyde-releasing compound that releases formaldehyde through its decomposition. Diazolidinyl urea is effective against most contaminating microorganisms, especially Pseudomonas[1][2].
Related Catalog
References

[1]. Kantor GR, et al. Acute allergic contact dermatitis from diazolidinyl urea (Germall II) in a hair gel. J Am Acad Dermatol. 1985;13(1):116-119.

[2]. Doi T, et al. The different decomposition properties of diazolidinyl urea in cosmetics and patch test materials. Contact Dermatitis. 2011;65(2):81-91.

[3]. Perret CM, et al. Contact sensitivity to diazolidinyl urea (Germall II). Arch Dermatol Res. 1989;281(1):57-59.

 Chemical & Physical Properties

Density 1.8±0.1 g/cm3
Boiling Point 421.04°C (rough estimate)
Molecular Formula C8H14N4O7
Molecular Weight 278.219
Exact Mass 278.086243
PSA 153.88000
LogP -3.69
Index of Refraction 1.703
Storage condition 2-8°C
Stability Stable. Incompatible with strong oxidizing agents.

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
YS2717000
CHEMICAL NAME :
Urea, N-(1,3-bis(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl) -N,N'-bis(hydroxymeth yl)-
CAS REGISTRY NUMBER :
78491-02-8
LAST UPDATED :
199806
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C8-H14-N4-O7

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 9(2),229,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3573 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
JTOTDO Journal of Toxicology, Cutaneous and Ocular Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1982- Volume(issue)/page/year: 14,3,1995
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
JTOTDO Journal of Toxicology, Cutaneous and Ocular Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1982- Volume(issue)/page/year: 14,3,1995
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - wild bird species
DOSE/DURATION :
>2250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JTOTDO Journal of Toxicology, Cutaneous and Ocular Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1982- Volume(issue)/page/year: 14,3,1995 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
11200 mg/kg/7D-I
TOXIC EFFECTS :
Behavioral - food intake (animal) Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 9(2),229,1990
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
26100 mg/kg/29D-I
TOXIC EFFECTS :
Gastrointestinal - gastritis Endocrine - changes in adrenal weight Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 9(2),229,1990 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2520 No. of Facilities: 429 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 6467 (estimated) No. of Female Employees: 6039 (estimated)

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H317
Precautionary Statements P280
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes Xi:Irritant
Risk Phrases R43
Safety Phrases S36/37
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS YS2717000
HS Code 2933990090

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles27

More Articles
Non-fragrance allergens in specific cosmetic products.

Contact Dermatitis 65(5) , 276-85, (2011)

Reports about the nature of the ingredients responsible for allergic contact dermatitis caused by specific cosmetic products are scarce.Between January 2000 and December 2010, the specific cosmetic pr...

Investigation on formaldehyde release from preservatives in cosmetics.

Int. J. Cosmet. Sci. 37 , 474-8, (2015)

To understand formaldehyde residue in cosmetics, an investigation on formaldehyde release from eight preservatives (methenamine - MA, paraformaldehyde - PF, poly(p-toluenesulfonamide-co-formaldehyde) ...

Hand dermatitis: a focus on allergic contact dermatitis to biocides.

Dermatol. Clin. 27(3) , 251-64, v-vi, (2009)

Hand dermatitis is a common disease of the skin resulting in significantly decreased quality of life. Allergic contact dermatitis is a frequent cause of hand dermatitis. Recent studies have revealed t...

 Synonyms

1-[1,3-Bis(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]-1,3-bis(hydroxymethyl)urea
Diazolidinylurea
N-[1,3-Bis(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]-N,N'-bis(hydroxymethyl)urea
Diazolidinyl urea
MFCD00079129
urea, diazolidinyl
EINECS 278-928-2
1-[1,3-Bis(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]-1,3-bis(hydroxymethyl)urea
Urea, N-[1,3-bis(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]-N,N'-bis(hydroxymethyl)-
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.
Top Suppliers:I want be here

Get all suppliers and price by the below link:

Diazolidinyl urea suppliers

Price: ￥550/10 mM * 1 mL in DMSO

Reference only. check more Diazolidinyl urea price

Related Compounds: More...
oxaldehyde,urea
53037-34-6
ac1l591v
69898-35-7
Danirixin
954126-98-8
(methylthiocarbamoylamino)urea
6634-45-3
Ethylurea
625-52-5
(cyclopentylamino)urea
7463-60-7
dichlorobis(urea-N)palladium
37500-03-1
N-[1-[[(3S)-1-fluoro-2-oxo-5-phenylpentan-3-yl]amino]-1-oxo-3-phenylpropan-2-yl]morpholine-4-carboxamide
148504-23-8
POLY(UREA-CO-FORMALDEHYDE), BUTYLATED
68002-19-7
N-(5-((2-((4-bromophenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)-4-fluorobenzamide
393566-95-5
2-nitro-N-(5-((2-oxo-2-(m-tolylamino)ethyl)thio)-1,3,4-thiadiazol-2-yl)benzamide
392292-18-1
N-(5-((2-((4-fluorophenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)-3-nitrobenzamide
392297-65-3
Chemsrc provides Diazolidinyl urea(CAS#:78491-02-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Diazolidinyl urea are included as well.>> amp version: Diazolidinyl urea

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved