2,6-xylidine

Modify Date: 2026-07-01 19:52:00

2,6-xylidine structure	Common Name	2,6-xylidine
	CAS Number	87-62-7	Molecular Weight	121.180
	Density	1.0±0.1 g/cm3	Boiling Point	217.9±0.0 °C at 760 mmHg
	Molecular Formula	C₈H₁₁N	Melting Point	10-12 °C(lit.)
	MSDS	Chinese USA	Flash Point	91.1±0.0 °C
	Symbol	GHS07, GHS08, GHS09	Signal Word	Warning

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	2,6-dimethylaniline
Synonym	More Synonyms

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.0±0.1 g/cm3
Boiling Point	217.9±0.0 °C at 760 mmHg
Melting Point	10-12 °C(lit.)
Molecular Formula	C₈H₁₁N
Molecular Weight	121.180
Flash Point	91.1±0.0 °C
Exact Mass	121.089149
PSA	26.02000
LogP	1.86
Vapour Pressure	0.1±0.4 mmHg at 25°C
Index of Refraction	1.559
InChIKey	UFFBMTHBGFGIHF-UHFFFAOYSA-N
SMILES	Cc1cccc(C)c1N
Water Solubility	7.5 g/L (20 ºC)

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

2,6-xylidine MSDS(Chinese)

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ZE9275000

CHEMICAL NAME :: 2,6-Xylidine

CAS REGISTRY NUMBER :: 87-62-7

BEILSTEIN REFERENCE NO. :: 0636332

LAST UPDATED :: 199710

DATA ITEMS CITED :: 19

MOLECULAR FORMULA :: C8-H11-N

MOLECULAR WEIGHT :: 121.20

WISWESSER LINE NOTATION :: ZR B1 F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 840 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - cyanosis Blood - changes in spleen

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 707 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3150 mg/kg/20D-C

TOXIC EFFECTS :: Blood - changes in spleen

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6200 mg/kg/2W-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 13300 mg/kg/4W-I

TOXIC EFFECTS :: Liver - other changes Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 20150 mg/kg/13W-I

TOXIC EFFECTS :: Brain and Coverings - changes in brain weight Liver - changes in liver weight Blood - changes in other cell count (unspecified)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 107 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Endocrine - tumors

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 301 mg/L

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 10(Suppl 10),1,1987 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 57,323,1993 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 57,323,1993 IARC Cancer Review:Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 57,323,1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7951 No. of Facilities: 21 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 4354 (estimated) No. of Female Employees: 729 (estimated)

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol	GHS07, GHS08, GHS09
Signal Word	Warning
Hazard Statements	H302 + H312 + H332-H315-H335-H351-H411
Precautionary Statements	P261-P273-P280
Personal Protective Equipment	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xn:Harmful;N:Dangerousfortheenvironment;
Risk Phrases	R20/21/22;R37/38;R40;R51/53
Safety Phrases	S23-S25-S36/37-S61
RIDADR	UN 1711 6.1/PG 2
WGK Germany	2
RTECS	ZE9275000
Packaging Group	II
Hazard Class	6.1
HS Code	29214910

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 9
CAS#:100379-00-8 3,5-Dimethylphe... CAS#:576-22-7 2,6-Dimethylbro... CAS#:6781-98-2 3-Chloro-o-xylene CAS#:81-20-9 nitro m-xylene
CAS#:576-26-1 2,6-Xylenol CAS#:24596-19-8 4-bromo-2,6-xylidine CAS#:187737-37-7 propene CAS#:286851-15-8 N-(1-ethyl-1-pr...
CAS#:107-02-8 acrolein
DownStream 10
CAS#:10553-07-8 1H-Indole, 7-Me... CAS#:106699-92-7 2-chloro-N-(2,6... CAS#:607-92-1 Formamide,N-(2,... CAS#:527-61-7 2,6-dimethyl-p-...
CAS#:81-20-9 nitro m-xylene CAS#:500287-72-9 Rilpivirine CAS#:608-28-6 m-xylene, 2-iodo CAS#:4397-14-2 Benzenemethanol...
CAS#:39627-98-0 N-(2,6-Dimethyl... CAS#:3176-66-7 7-Methyl-1H-indazole

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code	2921430090
Summary	HS:2921430090 toluidines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

This table lists relevant public references with title, journal and publication metadata for this compound.

Simultaneous Determination of Xylazine and 2,6-Xylidine in Blood and Urine by Auto Solid-Phase Extraction and Ultra High Performance Liquid Chromatography Coupled with Quadrupole-Time of Flight Mass Spectrometry.

J. Anal. Toxicol. 39 , 444-50, (2015)

Xylazine as veterinary medicine for sedation, but intoxication cases in humans were identified in the last few years. A highly sensitive method is required for analyzing xylazine and its metabolites i...

A Novel Method for Assessing Drug Degradation Product Safety Using Physiologically-Based Pharmacokinetic Models and Stochastic Risk Assessment.

J. Pharm. Sci. 104 , 3101-19, (2015)

Patient safety risk due to toxic degradation products is a potentially critical quality issue for a small group of useful drug substances. Although the pharmacokinetics of toxic drug degradation produ...

Concentrations of dimethylaniline and other metabolites in milk and tissues of dairy cows treated with lidocaine.

Food Addit. Contam. Part A. Chem. Anal. Control. Expo. Risk Assess. 32 , 1256-64, (2015)

Lidocaine is a topical anaesthetic drug used in dairy cows for laparotomy (caesarean section, abomasal displacement). Because there are no registered drugs for this indication, it can be applied under...

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273

Name: p53 small molecule agonists, cell-based qHTS assay: qHTS cell viability counter scree...
Source: 824
Target: N/A
External Id: P53600

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: qHTS ce...
Source: 824
Target: N/A
External Id: P53MS958

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: Summary
Source: 824
External Id: P53MS482

Name: p53 small molecule agonists, cell-based qHTS assay
Source: 824
External Id: P53344

Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS233

Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes: qHTS ...
Source: 824
Target: N/A
External Id: P53MS837

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS898

Name: qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity
Source: NCGC
External Id: HERG01

Name: Adrenergic beta2 receptor (ADRB2) small molecule agonists, cell-based qHTS assay
Source: 824
External Id: ADRB2293

Total 214, Current Page 1 of 22

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

o-Xylidine

2-Amino-1,3-xylene

2,6-dimethyl-aniline

1-amino-2,6-dimethybenzene

Benzenamine,2,6-dimethyl

2,6-xylidine

2,6-dimethylphenylamine

2,6-dimethylbenzeneamine

MFCD00007747

2-amino-1,3-dimethylbenzene

2,6-Dimethylbenzenamine

2,6-Dimethylaniline

2-Amino-m-xylene

2,5-DIMETHOXYTOLUENE

1-amino-2,6-dimethylbenzene

2,6-methylaniline

EINECS 201-758-7

2,6-dimethyl aniline

Bupivacaine Impurity 8

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the molecular formula of 2,6-dimethylaniline?

A: Molecular formula of 2,6-dimethylaniline is C8H11N.

Q: How is the water solubility of 2,6-dimethylaniline?

A: Water solubility of 2,6-dimethylaniline: 7.5 g/L (20 ºC).

Q: What is the English name of 2,6-dimethylaniline?

A: The English name of 2,6-dimethylaniline is 2,6-dimethylaniline.

Q: What is the InChIKey of 2,6-dimethylaniline?

A: InChIKey of 2,6-dimethylaniline is UFFBMTHBGFGIHF-UHFFFAOYSA-N.

Q: What is the SMILES notation of 2,6-dimethylaniline?

A: SMILES notation of 2,6-dimethylaniline is Cc1cccc(C)c1N.

Q: What is the boiling point of 2,6-dimethylaniline?

A: Boiling point of 2,6-dimethylaniline is 217.9±0.0 °C at 760 mmHg.

Q: What is the safety information for 2,6-dimethylaniline?

A: Safety information for 2,6-dimethylaniline: S23-S25-S36/37-S61.

Q: What English synonyms does 2,6-dimethylaniline have?

A: English synonyms of 2,6-dimethylaniline: o-Xylidine, 2-Amino-1,3-xylene, 2,6-dimethyl-aniline, 1-amino-2,6-dimethybenzene, Benzenamine,2,6-dimethyl, 2,6-xylidine, 2,6-dimethylphenylamine, 2,6-dimethylbenzeneamine, MFCD00007747, 2-amino-1,3-dimethylbenzene, 2,6-Dimethylbenzenamine, 2,6-Dimethylaniline, 2-Amino-m-xylene, 2,5-DIMETHOXYTOLUENE, 1-amino-2,6-dimethylbenzene, 2,6-methylaniline, EINECS 201-758-7, 2,6-dimethyl aniline, Bupivacaine Impurity 8.

Q: What is the CAS number of 2,6-dimethylaniline?

A: CAS number of 2,6-dimethylaniline is 87-62-7.

Q: What are the upstream materials of 2,6-dimethylaniline?

A: Related upstream materials(CAS) of 2,6-dimethylaniline: 100379-00-8;576-22-7;6781-98-2;81-20-9;576-26-1;24596-19-8;187737-37-7;286851-15-8;107-02-8.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

Dayang Chem (Hangzhou) Co., Ltd.

Henan Tianfu Chemical Co., Ltd.

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 2,6-xylidine
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2,6-Dimethylaniline
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: 2,6-dimethylaniline
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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2,6-xylidine

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