PEG2-Cl

Modify Date: 2024-01-08 12:46:10

PEG2-Cl Structure
PEG2-Cl structure
Common Name PEG2-Cl
CAS Number 78925-46-9 Molecular Weight 138.593
Density 1.1±0.1 g/cm3 Boiling Point 236.9±15.0 °C at 760 mmHg
Molecular Formula C5H11ClO2 Melting Point N/A
MSDS N/A Flash Point 97.1±20.4 °C

 Use of PEG2-Cl


PEG2-Cl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 3-(2-Chloroethoxy)-1-propanol
Synonym More Synonyms

 PEG2-Cl Biological Activity

Description PEG2-Cl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 236.9±15.0 °C at 760 mmHg
Molecular Formula C5H11ClO2
Molecular Weight 138.593
Flash Point 97.1±20.4 °C
Exact Mass 138.044754
PSA 29.46000
LogP 0.26
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.441

 Synonyms

1-Propanol, 3-(2-chloroethoxy)-
3-(2-Chloroethoxy)-1-propanol
3-(2-chloroethoxy)propan-1-ol