Methacrylamide

Modify Date: 2026-07-02 08:26:45

Methacrylamide Structure
Methacrylamide structure
Common Name Methacrylamide
CAS Number 79-39-0 Molecular Weight 85.10
Density 0.9±0.1 g/cm3 Boiling Point 211.5±13.0 °C at 760 mmHg
Molecular Formula C4H7NO Melting Point 108 °C
MSDS Chinese USA Flash Point 81.7±19.8 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of Methacrylamide


Methacrylamide can be used as an excipient. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1].

Summary: Methacrylamide, Chinese name 甲基丙烯酰胺, molecular formula C4H7NO, molecular weight 85.10. It is a colorless solid crystal, melting point 108 °C, boiling point 211.5±13.0 °C. For research-use only, not for medical or clinical usage.


 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name methacrylamide
Synonym More Synonyms

 Methacrylamide Biological Activity

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description Methacrylamide can be used as an excipient. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1].
Related Catalog
References

[1]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99.  

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density 0.9±0.1 g/cm3
Boiling Point 211.5±13.0 °C at 760 mmHg
Melting Point 108 °C
Molecular Formula C4H7NO
Molecular Weight 85.10
Flash Point 81.7±19.8 °C
Exact Mass 85.052765
PSA 43.09000
LogP -0.23
Vapour Pressure 0.2±0.4 mmHg at 25°C
Index of Refraction 1.438
InChIKey FQPSGWSUVKBHSU-UHFFFAOYSA-N
SMILES C=C(C)C(N)=O
Water Solubility 202 g/L (20 ºC)

 MSDS

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

 Toxicological Information

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UC6475000
CHEMICAL NAME :
2-Propenamide, 2-methyl-
CAS REGISTRY NUMBER :
79-39-0
BEILSTEIN REFERENCE NO. :
0605397
LAST UPDATED :
199710
DATA ITEMS CITED :
13
MOLECULAR FORMULA :
C4-H7-N-O
MOLECULAR WEIGHT :
85.12
WISWESSER LINE NOTATION :
ZVY1&U1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
3 mg/m3
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes Liver - other changes Kidney, Ureter, Bladder - other changes
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 45(10),74,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
459 mg/kg
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes Liver - other changes Kidney, Ureter, Bladder - other changes
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 45(10),74,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>6 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 45(10),74,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
451 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 47,179,1981
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>6 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 45(10),74,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
2160 mg/kg
SEX/DURATION :
female 6-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - parturition Reproductive - Maternal Effects - other effects Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB91-208678
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1440 mg/kg
SEX/DURATION :
female 6-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB91-208678 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 1 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M5220 No. of Facilities: 55 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1031 (estimated)

 Safety Information

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes Xn:Harmful;
Risk Phrases R22;R36/37/38
Safety Phrases S26-S36/37
RIDADR 3263
WGK Germany 1
RTECS UC6475000
Packaging Group III
Hazard Class 6.1(b)
HS Code 2924199090

 Synthetic Route

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

 Customs

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code 2924199090
Summary 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Articles33

More Articles

This table lists relevant public references with title, journal and publication metadata for this compound.

Sulfobetaine-Vinylimidazole Block Copolymers: A Robust Quantum Dot Surface Chemistry Expanding Bioimaging's Horizons.

ACS Nano 9 , 11479-89, (2015)

Long-term inspection of biological phenomena requires probes of elevated intra- and extracellular stability and target biospecificity. The high fluorescence and photostability of quantum dot (QD) nano...

Metal-free synthesis of 3,3-disubstituted oxoindoles by iodine(III)-catalyzed bromocarbocyclizations.

Chemistry 18(35) , 10834-8, (2012)

"I" did it: An iodine(III)-mediated bromocarbocyclization was elaborated as an efficient tool for the synthesis of oxoindoles. This method is applicable to a variety of structurally different substrat...

Photochemical internalization-mediated nonviral gene transfection: polyamine core-shell nanoparticles as gene carrier.

J. Biomed. Opt. 19(10) , 105009, (2014)

The overall objective of the research was to investigate the utility of photochemical internalization (PCI) for the enhanced nonviral transfection of genes into glioma cells. The PCI-mediated introduc...

 Synonyms

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

Methacrylamide
Methylacrylic amide
2-Methylpropenamide
Methacryamide
EINECS 201-202-3
methylacrylamide
2-methylprop-2-enamide
MFCD00008018
Methacrylic acid amide
2-Propenamide,2-methyl
2-Methylacrylamide
methacrylic amide
methylbisacrylamide
2-Methyl-2-propenamide

 Methacrylamide | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the English name of methacrylamide?
A: The English name of methacrylamide is methacrylamide.
Q: What is the melting point of methacrylamide?
A: Melting point of methacrylamide is 108 °C.
Q: What is the polar surface area (PSA) of methacrylamide?
A: Polar surface area (PSA) of methacrylamide is 43.09000.
Q: What is the LogP of methacrylamide?
A: LogP of methacrylamide is -0.23.
Q: What is the safety information for methacrylamide?
A: Safety information for methacrylamide: S26-S36/37.
Q: What is the molecular weight of methacrylamide?
A: Molecular weight of methacrylamide is 85.10.
Q: What is the SMILES notation of methacrylamide?
A: SMILES notation of methacrylamide is C=C(C)C(N)=O.
Q: What is the molecular formula of methacrylamide?
A: Molecular formula of methacrylamide is C4H7NO.
Q: What is the boiling point of methacrylamide?
A: Boiling point of methacrylamide is 211.5±13.0 °C at 760 mmHg.
Q: What English synonyms does methacrylamide have?
A: English synonyms of methacrylamide: Methacrylamide, Methylacrylic amide, 2-Methylpropenamide, Methacryamide, EINECS 201-202-3, methylacrylamide, 2-methylprop-2-enamide, MFCD00008018, Methacrylic acid amide, 2-Propenamide,2-methyl, 2-Methylacrylamide, methacrylic amide, methylbisacrylamide, 2-Methyl-2-propenamide.

 Methacrylamidefactory

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd
Dayang Chem (Hangzhou) Co., Ltd.
Henan Tianfu Chemical Co., Ltd.
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