NGI 1

Modify Date: 2024-01-14 17:37:39

NGI 1 Structure
NGI 1 structure
Common Name NGI 1
CAS Number 790702-57-7 Molecular Weight 394.512
Density 1.4±0.1 g/cm3 Boiling Point N/A
Molecular Formula C17H22N4O3S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of NGI 1


NGI-1 is a cell permeable inhibitor.

 Names

Name NGI-1
Synonym More Synonyms

 NGI 1 Biological Activity

Description NGI-1 is a cell permeable inhibitor.
Related Catalog
In Vitro NGI-1 blocks EGFR N-linked glycosylation in lung adenocarcinoma cells as assessed. In controls EGFR is biotinylated, consistent with its plasma membrane expression, but in NGI-1 treated cells the EGFR is predominantly found in the non-biotinylated intracellular fraction suggesting a change in cellular localization[1].
References

[1]. Lopez-Sambrooks C, et al. Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells. Nat Chem Biol. 2016 Dec;12(12):1023-1030.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Molecular Formula C17H22N4O3S2
Molecular Weight 394.512
Exact Mass 394.113342
LogP 2.75
Index of Refraction 1.634
Storage condition -20℃

 Synonyms

MFCD06358908
5-(Dimethylsulfamoyl)-N-(5-methyl-1,3-thiazol-2-yl)-2-(1-pyrrolidinyl)benzamide
Benzamide, 5-[(dimethylamino)sulfonyl]-N-(5-methyl-2-thiazolyl)-2-(1-pyrrolidinyl)-