ASP 2905

Modify Date: 2025-08-26 18:41:39

ASP 2905 Structure
ASP 2905 structure
 Common Name ASP 2905
CAS Number 792184-90-8 Molecular Weight 388.401
Density 1.4±0.1 g/cm3 Boiling Point 600.5±65.0 °C at 760 mmHg
Molecular Formula C20H17FN8 Melting Point N/A
MSDS N/A Flash Point 317.0±34.3 °C

 Use of ASP 2905


ASP 2905 (ASP2905) is a novel potent, selective, orally bioavailable inhibitor of voltage-gated potassium channel KCNH3 with IC50 of 9.0 nM; displays minimally bound with low affinities to 55 transmembrane proteins; decreases the frequency of spontaneous inhibitory postsynaptic currents in cultured rat hippocampal neurons at 0.1-1 uM; reverses the disruption of spontaneous alternation behavior induced by MK-801 and scopolamine in mice, and ameliorates the cognitive deficits of aged rats. Alzheimer Disease Phase 1 Discontinued

 Names

Name N2-(4-Fluorophenyl)-N4-phenyl-N6-(2-pyrimidinylmethyl)-1,3,5-triazine-2,4,6-triamine
Synonym More Synonyms

 ASP 2905 Biological Activity

Description ASP 2905 (ASP2905) is a novel potent, selective, orally bioavailable inhibitor of voltage-gated potassium channel KCNH3 with IC50 of 9.0 nM; displays minimally bound with low affinities to 55 transmembrane proteins; decreases the frequency of spontaneous inhibitory postsynaptic currents in cultured rat hippocampal neurons at 0.1-1 uM; reverses the disruption of spontaneous alternation behavior induced by MK-801 and scopolamine in mice, and ameliorates the cognitive deficits of aged rats. Alzheimer Disease Phase 1 Discontinued
References References 1. Takahashi S, et al. Eur J Pharmacol. 2017 Sep 5;810:26-35. View Related Products by Target Potassium Channel Alzheimer Disease

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 600.5±65.0 °C at 760 mmHg
Molecular Formula C20H17FN8
Molecular Weight 388.401
Flash Point 317.0±34.3 °C
Exact Mass 388.156006
LogP 2.26
Vapour Pressure 0.0±1.7 mmHg at 25°C
Index of Refraction 1.739

 Synonyms

1,3,5-Triazine-2,4,6-triamine, N2-(4-fluorophenyl)-N4-phenyl-N6-(2-pyrimidinylmethyl)-
N2-(4-Fluorophenyl)-N4-phenyl-N6-(2-pyrimidinylmethyl)-1,3,5-triazine-2,4,6-triamine
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