Maduramicin

Modify Date: 2024-01-14 15:09:48

Maduramicin Structure
Maduramicin structure
Common Name Maduramicin
CAS Number 79356-08-4 Molecular Weight 917.13
Density 1.3±0.1 g/cm3 Boiling Point 913.9±65.0 °C at 760 mmHg
Molecular Formula C47H80O17 Melting Point N/A
MSDS N/A Flash Point 255.5±27.8 °C

 Use of Maduramicin


Maduramicin (Maduramycin) is isolated from the actinomycete Actinomadura rubra. Maduramicin is an anticoccidial agent for the the treatment of Eimeria spp., E. adenoeides, E. gallopavonis, and E. dispersa infection[1]. Maduramicin induces cell apoptosis in chicken myocardial cells via intrinsic and extrinsic pathways[2].

 Names

Name [(2R,3S,4S,5R,6S)-6-{(1R)-1-[(2S,5R,7S,8R,9S)-2-{(2S,2'R,3'S,5R,5'R)-3'-{[(2R,4S,5S,6S)-4,5-Dimethoxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-5'-[(2S,3S,5R,6S)-6-hydroxy-3,5,6-trimethyltetrahydro-2H-pyran-2-yl]-2-methyloctahydro-2,2'-bifuran-5-yl}-9-hydroxy-2,8-dimethyl-1,6-dioxaspiro[4.5]dec-7-yl]ethyl}-2-hydroxy-4,5-dimethoxy-3-methyltetrahydro-2H-pyran-2-yl]acetic acid
Synonym More Synonyms

 Maduramicin Biological Activity

Description Maduramicin (Maduramycin) is isolated from the actinomycete Actinomadura rubra. Maduramicin is an anticoccidial agent for the the treatment of Eimeria spp., E. adenoeides, E. gallopavonis, and E. dispersa infection[1]. Maduramicin induces cell apoptosis in chicken myocardial cells via intrinsic and extrinsic pathways[2].
Related Catalog
References

[1]. McDougald LR, et al. Efficacy of maduramicin ammonium against coccidiosis in turkeys under laboratory and floor-pen conditions.Avian Dis. 1990 Jul-Sep;34(3):634-8.  

[2]. Gao X, et al.Maduramicin induces apoptosis in chicken myocardial cells via intrinsic and extrinsic pathways.Toxicol In Vitro. 2018 Aug;50:190-200.  

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 913.9±65.0 °C at 760 mmHg
Molecular Formula C47H80O17
Molecular Weight 917.13
Flash Point 255.5±27.8 °C
Exact Mass 916.539551
PSA 208.75000
LogP 4.34
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.549

 Synonyms

2-(6-(1-(2-(3'-((4,5-dimethoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-5'-(6-hydroxy-3,5,6-trimethyltetrahydro-2H-pyran-2-yl)-2-methyloctahydro-[2,2'-bifuran]-5-yl)-9-hydroxy-2,8-dimethyl-1,6-dioxaspiro[4.5]decan-7-yl)ethyl)-2-hydroxy-4,5-dimethoxy-3-methyltetrahydro-2H-pyran-2-yl)acetic acid
[(2R,3S,4S,5R,6S)-6-{(1R)-1-[(2S,5R,7S,8R,9S)-2-{(2S,2'R,3'S,5R,5'R)-3'-{[(2R,4S,5S,6S)-4,5-Dimethoxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-5'-[(2S,3S,5R,6S)-6-hydroxy-3,5,6-trimethyltetrahydro-2H-pyran-2-yl]-2-methyloctahydro-2,2'-bifuran-5-yl}-9-hydroxy-2,8-dimethyl-1,6-dioxaspiro[4.5]dec-7-yl]ethyl}-2-hydroxy-4,5-dimethoxy-3-methyltetrahydro-2H-pyran-2-yl]acetic acid