3-Fluoro-4-hydroxy-5-methoxybenzaldehyde

Modify Date: 2024-01-02 19:16:21

3-Fluoro-4-hydroxy-5-methoxybenzaldehyde Structure
3-Fluoro-4-hydroxy-5-methoxybenzaldehyde structure
Common Name 3-Fluoro-4-hydroxy-5-methoxybenzaldehyde
CAS Number 79418-78-3 Molecular Weight 170.138
Density 1.3±0.1 g/cm3 Boiling Point 248.6±35.0 °C at 760 mmHg
Molecular Formula C8H7FO3 Melting Point 114-118 °C(lit.)
MSDS Chinese USA Flash Point 104.1±25.9 °C
Symbol GHS07
GHS07
Signal Word Warning

 Names

Name 3-Fluoro-4-hydroxy-5-methoxybenzaldehyde
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 248.6±35.0 °C at 760 mmHg
Melting Point 114-118 °C(lit.)
Molecular Formula C8H7FO3
Molecular Weight 170.138
Flash Point 104.1±25.9 °C
Exact Mass 170.037918
PSA 46.53000
LogP 1.67
Vapour Pressure 0.0±0.5 mmHg at 25°C
Index of Refraction 1.564

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2913000090

 Synthetic Route

~91%

3-Fluoro-4-hydroxy-5-methoxybenzaldehyde Structure

3-Fluoro-4-hydr...

CAS#:79418-78-3

Literature: Jiang, Jian-An; Chen, Cheng; Guo, Ying; Liao, Dao-Hua; Pan, Xian-Dao; Ji, Ya-Fei Green Chemistry, 2014 , vol. 16, # 5 p. 2807 - 2814

~%

3-Fluoro-4-hydroxy-5-methoxybenzaldehyde Structure

3-Fluoro-4-hydr...

CAS#:79418-78-3

Literature: Lim, Kwang Su; Lee, Hobin; Kim, Sung Eun; Ha, Tae-Hwan; Ann, Jihyae; Son, Karam; Choi, Sun; Sun, Wei; Pearce, Larry V.; Deandrea-Lazarus, Ian A.; Blumberg, Peter M.; Lee, Jeewoo European Journal of Medicinal Chemistry, 2013 , vol. 68, p. 233 - 243

~36%

3-Fluoro-4-hydroxy-5-methoxybenzaldehyde Structure

3-Fluoro-4-hydr...

CAS#:79418-78-3

Literature: EP2557082 A1, ; Paragraph 0343; 0345 ;

~36%

3-Fluoro-4-hydroxy-5-methoxybenzaldehyde Structure

3-Fluoro-4-hydr...

CAS#:79418-78-3

Literature: Lim, Kwang Su; Kang, Dong Wook; Kim, Yong Soo; Kim, Myeong Seop; Park, Seul-Gi; Choi, Sun; Pearce, Larry V.; Blumberg, Peter M.; Lee, Jeewoo Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 1 p. 299 - 302

~%

3-Fluoro-4-hydroxy-5-methoxybenzaldehyde Structure

3-Fluoro-4-hydr...

CAS#:79418-78-3

Literature: Journal of Organic Chemistry, , vol. 51, # 21 p. 4072 - 4073

~%

3-Fluoro-4-hydroxy-5-methoxybenzaldehyde Structure

3-Fluoro-4-hydr...

CAS#:79418-78-3

Literature: Journal of Organic Chemistry, , vol. 51, # 21 p. 4072 - 4073

~%

3-Fluoro-4-hydroxy-5-methoxybenzaldehyde Structure

3-Fluoro-4-hydr...

CAS#:79418-78-3

Detail
Literature: Creveling; McNeal; Cantacuzene; Kirk Journal of Medicinal Chemistry, 1981 , vol. 24, # 12 p. 1395 - 1399

~%

3-Fluoro-4-hydroxy-5-methoxybenzaldehyde Structure

3-Fluoro-4-hydr...

CAS#:79418-78-3

Literature: Journal of Medicinal Chemistry, , vol. 24, # 12 p. 1395 - 1399

 Customs

HS Code 2913000090
Summary HS: 2913000090 halogenated, sulphonated, nitrated or nitrosated derivatives of products of heading 2912 Educational tariff:17.0% Tax rebate rate:9.0% Regulatory conditions:none Most favored nation tariff:5.5% General tariff:30.0%

 Articles2

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Synthesis of a series of caffeic acid phenethyl amide (CAPA) fluorinated derivatives: comparison of cytoprotective effects to caffeic acid phenethyl ester (CAPE).

Bioorg. Med. Chem. 18(14) , 5032-8, (2010)

A series of catechol ring-fluorinated derivatives of caffeic acid phenethyl amide (CAPA) were synthesized and screened for cytoprotective activity against H2O2 induced oxidative stress in human umbili...

The new Schiff base 4-[(4-Hydroxy-3-fluoro-5-methoxy-benzylidene) amino]-1, 5-dimethyl-2-phenyl-1, 2-dihydro-pyrazol-3-one: Experimental, DFT calculational studies and in vitro antimicrobial activity. Iskeleli NO, et al.

Spectrochim. Acta A 139 , 356-366, (2015)

 Synonyms

3-Fluoro-4-hydroxy-5-methoxybenzaldehyde
Benzaldehyde, 3-fluoro-4-hydroxy-5-methoxy-
MFCD02683560