Head activator

Modify Date: 2024-01-06 19:30:19

Head activator Structure
Head activator structure
Common Name Head activator
CAS Number 79943-68-3 Molecular Weight 1125.32000
Density 1.271g/cm3 Boiling Point 1506.5ºC at 760 mmHg
Molecular Formula C54H84N12O14 Melting Point N/A
MSDS N/A Flash Point 864.9ºC

 Use of Head activator


Head activator neuropeptide is a mitogen for mammalian cell lines of neuronal or neuroendocrine origin. Head activator neuropeptide signals by binding GPR37 and stimulates cells to enter mitosis[1].

 Names

Name head activator neuropeptide

 Head activator Biological Activity

Description Head activator neuropeptide is a mitogen for mammalian cell lines of neuronal or neuroendocrine origin. Head activator neuropeptide signals by binding GPR37 and stimulates cells to enter mitosis[1].
Related Catalog
Target

GPR37[1]

In Vitro Head activator neuropeptide (2 nM,0-60 分钟) 在转染了 GPR37-FLAG 的 COS-7 细胞中刺激 GPR37 的内化[1]。 Head activator neuropeptide (EC50: 3.3 nM) 增加转染载脂蛋白和 GPR37[1] 的 CHO-K1 细胞中的 Ca2+ mobilisation[1]。 Head activator neuropeptide (EC50: 5.6 nM) 刺激表达 GPR37 的青蛙卵母细胞的电流增加[1]。
References

[1]. Rezgaoui M, et al. The neuropeptide head activator is a high-affinity ligand for the orphan G-protein-coupled receptor GPR37. J Cell Sci. 2006 Feb 1;119(Pt 3):542-9.  

 Chemical & Physical Properties

Density 1.271g/cm3
Boiling Point 1506.5ºC at 760 mmHg
Molecular Formula C54H84N12O14
Molecular Weight 1125.32000
Flash Point 864.9ºC
Exact Mass 1124.62000
PSA 386.07000
LogP 1.61710
Index of Refraction 1.564

 Safety Information

WGK Germany 3