Boc-NH-O-C1-NHS ester
Boc-NH-O-C1-NHS ester structure
|
Common Name | Boc-NH-O-C1-NHS ester | ||
|---|---|---|---|---|
| CAS Number | 80366-85-4 | Molecular Weight | 288.25400 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C11H16N2O7 | Melting Point | 114 °C | |
| MSDS | N/A | Flash Point | N/A | |
Use of Boc-NH-O-C1-NHS esterBoc-NH-O-C1-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
Summary: (2,5-dioxopyrrolidin-1-yl) 2-[(2-methylpropan-2-yl)oxycarbonylamino]oxyacetate, also known as Boc-NH-O-C1-NHS ester, with CAS number 80366-85-4, molecular formula C11H16N2O7, and molecular weight 288.25400. It appears as a white to almost white powder or crystal, with a melting point of 114°C. For research-use only, not for medical or clinical usage.
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | (2,5-dioxopyrrolidin-1-yl) 2-[(2-methylpropan-2-yl)oxycarbonylamino]oxyacetate |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Boc-NH-O-C1-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
|---|---|
| Related Catalog | |
| Target |
Alkyl/ether |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Melting Point | 114 °C |
|---|---|
| Molecular Formula | C11H16N2O7 |
| Molecular Weight | 288.25400 |
| Exact Mass | 288.09600 |
| PSA | 114.73000 |
| LogP | 0.19220 |
| InChIKey | ZZBOTLREHORFCK-UHFFFAOYSA-N |
| SMILES | CC(C)(C)OC(=O)NOCC(=O)ON1C(=O)CCC1=O |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
|
~92%
Boc-NH-O-C1-NHS... CAS#:80366-85-4 |
| Literature: Deroo, Stephanie; Defrancq, Eric; Moucheron, Cecile; Kirsch-De Mesmaeker, Andree; Dumy, Pascal Tetrahedron Letters, 2003 , vol. 44, # 46 p. 8379 - 8382 |
|
~%
Boc-NH-O-C1-NHS... CAS#:80366-85-4 |
| Literature: Deroo, Stephanie; Defrancq, Eric; Moucheron, Cecile; Kirsch-De Mesmaeker, Andree; Dumy, Pascal Tetrahedron Letters, 2003 , vol. 44, # 46 p. 8379 - 8382 |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 3 | |
|---|---|
| DownStream 1 | |
![6-[[2-[(2-methylpropan-2-yl)oxycarbonylamino]oxyacetyl]amino]hexanoic acid structure](https://image.chemsrc.com/caspic/442/879898-82-5.png)
CAS#:879898-82-5This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| t-Boc-aminooxyacetic Acid N-Hydroxysuccinimide Ester |
| tBoc-aminooxyacetyl N-hydroxysuccinimide ester |
| N'-Boc-aminooxyacetyl N-hydroxysuccinimide ester |
| tBoc-AO-OSu |
| 2-tert-butoxycarbonylaminoxy-acetic acid 2,5-dioxo-pyrrolidin-1-yl ester |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What are the upstream materials of (2,5-dioxopyrrolidin-1-yl) 2-[(2-methylpropan-2-yl)oxycarbonylamino]oxyacetate? |
| A: Related upstream materials(CAS) of (2,5-dioxopyrrolidin-1-yl) 2-[(2-methylpropan-2-yl)oxycarbonylamino]oxyacetate: 6066-82-6;42989-85-5;24424-99-5. |
| Q: What is the LogP of (2,5-dioxopyrrolidin-1-yl) 2-[(2-methylpropan-2-yl)oxycarbonylamino]oxyacetate? |
| A: LogP of (2,5-dioxopyrrolidin-1-yl) 2-[(2-methylpropan-2-yl)oxycarbonylamino]oxyacetate is 0.19220. |
| Q: What is the CAS number of (2,5-dioxopyrrolidin-1-yl) 2-[(2-methylpropan-2-yl)oxycarbonylamino]oxyacetate? |
| A: CAS number of (2,5-dioxopyrrolidin-1-yl) 2-[(2-methylpropan-2-yl)oxycarbonylamino]oxyacetate is 80366-85-4. |
| Q: What is the molecular formula of (2,5-dioxopyrrolidin-1-yl) 2-[(2-methylpropan-2-yl)oxycarbonylamino]oxyacetate? |
| A: Molecular formula of (2,5-dioxopyrrolidin-1-yl) 2-[(2-methylpropan-2-yl)oxycarbonylamino]oxyacetate is C11H16N2O7. |
| Q: What is the SMILES notation of (2,5-dioxopyrrolidin-1-yl) 2-[(2-methylpropan-2-yl)oxycarbonylamino]oxyacetate? |
| A: SMILES notation of (2,5-dioxopyrrolidin-1-yl) 2-[(2-methylpropan-2-yl)oxycarbonylamino]oxyacetate is CC(C)(C)OC(=O)NOCC(=O)ON1C(=O)CCC1=O. |
| Q: What is the InChIKey of (2,5-dioxopyrrolidin-1-yl) 2-[(2-methylpropan-2-yl)oxycarbonylamino]oxyacetate? |
| A: InChIKey of (2,5-dioxopyrrolidin-1-yl) 2-[(2-methylpropan-2-yl)oxycarbonylamino]oxyacetate is ZZBOTLREHORFCK-UHFFFAOYSA-N. |
| Q: What is the polar surface area (PSA) of (2,5-dioxopyrrolidin-1-yl) 2-[(2-methylpropan-2-yl)oxycarbonylamino]oxyacetate? |
| A: Polar surface area (PSA) of (2,5-dioxopyrrolidin-1-yl) 2-[(2-methylpropan-2-yl)oxycarbonylamino]oxyacetate is 114.73000. |
| Q: What are the downstream products of (2,5-dioxopyrrolidin-1-yl) 2-[(2-methylpropan-2-yl)oxycarbonylamino]oxyacetate? |
| A: Related downstream products(CAS) of (2,5-dioxopyrrolidin-1-yl) 2-[(2-methylpropan-2-yl)oxycarbonylamino]oxyacetate: 879898-82-5. |
| Q: What is the molecular weight of (2,5-dioxopyrrolidin-1-yl) 2-[(2-methylpropan-2-yl)oxycarbonylamino]oxyacetate? |
| A: Molecular weight of (2,5-dioxopyrrolidin-1-yl) 2-[(2-methylpropan-2-yl)oxycarbonylamino]oxyacetate is 288.25400. |
| Q: What is the melting point of (2,5-dioxopyrrolidin-1-yl) 2-[(2-methylpropan-2-yl)oxycarbonylamino]oxyacetate? |
| A: Melting point of (2,5-dioxopyrrolidin-1-yl) 2-[(2-methylpropan-2-yl)oxycarbonylamino]oxyacetate is 114 °C. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |