Boc-NH-O-C1-NHS ester structure
|
Common Name | Boc-NH-O-C1-NHS ester | ||
---|---|---|---|---|
CAS Number | 80366-85-4 | Molecular Weight | 288.25400 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C11H16N2O7 | Melting Point | 114 °C | |
MSDS | N/A | Flash Point | N/A |
Use of Boc-NH-O-C1-NHS esterBoc-NH-O-C1-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
Name | (2,5-dioxopyrrolidin-1-yl) 2-[(2-methylpropan-2-yl)oxycarbonylamino]oxyacetate |
---|---|
Synonym | More Synonyms |
Description | Boc-NH-O-C1-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
---|---|
Related Catalog | |
Target |
Alkyl/ether |
In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
References |
Melting Point | 114 °C |
---|---|
Molecular Formula | C11H16N2O7 |
Molecular Weight | 288.25400 |
Exact Mass | 288.09600 |
PSA | 114.73000 |
LogP | 0.19220 |
~92% Boc-NH-O-C1-NHS... CAS#:80366-85-4 |
Literature: Deroo, Stephanie; Defrancq, Eric; Moucheron, Cecile; Kirsch-De Mesmaeker, Andree; Dumy, Pascal Tetrahedron Letters, 2003 , vol. 44, # 46 p. 8379 - 8382 |
~% Boc-NH-O-C1-NHS... CAS#:80366-85-4 |
Literature: Deroo, Stephanie; Defrancq, Eric; Moucheron, Cecile; Kirsch-De Mesmaeker, Andree; Dumy, Pascal Tetrahedron Letters, 2003 , vol. 44, # 46 p. 8379 - 8382 |
t-Boc-aminooxyacetic Acid N-Hydroxysuccinimide Ester |
tBoc-aminooxyacetyl N-hydroxysuccinimide ester |
N'-Boc-aminooxyacetyl N-hydroxysuccinimide ester |
tBoc-AO-OSu |
2-tert-butoxycarbonylaminoxy-acetic acid 2,5-dioxo-pyrrolidin-1-yl ester |