80366-85-4
80366-85-4 structure
- Name: Boc-NH-O-C1-NHS ester
- Chemical Name: (2,5-dioxopyrrolidin-1-yl) 2-[(2-methylpropan-2-yl)oxycarbonylamino]oxyacetate
- CAS Number: 80366-85-4
- Molecular Formula: C11H16N2O7
- Molecular Weight: 288.25400
- Catalog: Signaling Pathways PROTAC PROTAC Linker
- Create Date: 2017-04-18 13:28:07
- Modify Date: 2024-01-08 10:56:32
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Boc-NH-O-C1-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
| Name | (2,5-dioxopyrrolidin-1-yl) 2-[(2-methylpropan-2-yl)oxycarbonylamino]oxyacetate |
|---|---|
| Synonyms |
t-Boc-aminooxyacetic Acid N-Hydroxysuccinimide Ester
tBoc-aminooxyacetyl N-hydroxysuccinimide ester N'-Boc-aminooxyacetyl N-hydroxysuccinimide ester tBoc-AO-OSu 2-tert-butoxycarbonylaminoxy-acetic acid 2,5-dioxo-pyrrolidin-1-yl ester |
| Description | Boc-NH-O-C1-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
|---|---|
| Related Catalog | |
| Target |
Alkyl/ether |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References |
| Melting Point | 114 °C |
|---|---|
| Molecular Formula | C11H16N2O7 |
| Molecular Weight | 288.25400 |
| Exact Mass | 288.09600 |
| PSA | 114.73000 |
| LogP | 0.19220 |
| Precursor 3 | |
|---|---|
| DownStream 1 | |
![6-[[2-[(2-methylpropan-2-yl)oxycarbonylamino]oxyacetyl]amino]hexanoic acid structure](https://image.chemsrc.com/caspic/442/879898-82-5.png)