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80366-85-4

80366-85-4 structure

80366-85-4 structure

Name: Boc-NH-O-C1-NHS ester
Chemical Name: (2,5-dioxopyrrolidin-1-yl) 2-[(2-methylpropan-2-yl)oxycarbonylamino]oxyacetate
CAS Number: 80366-85-4
Molecular Formula: C₁₁H₁₆N₂O₇
Molecular Weight: 288.25400
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2017-04-18 13:28:07
Modify Date: 2026-07-01 13:14:43
Boc-NH-O-C1-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	(2,5-dioxopyrrolidin-1-yl) 2-[(2-methylpropan-2-yl)oxycarbonylamino]oxyacetate
Synonyms	N-Succinimidyl [(tert-Butoxycbonyl)aminooxy]acetate N-Bocaminooxy-aceticacid2,5-dioxo-pyrrolidin-1-ylester Boc-Aoa-OSu Inhibitor,PROTAC Linkers,Boc NH O C1 NHS ester,inhibit,BocNHOC1NHS ester,Boc-NH-O-C-1-NHS ester (Boc-aminooxy)acetic Acid N-Succinimidyl Ester N-Boc-aminooxyacetic acid N-hydroxysuccinimide ester Boc-aminooxyacetic acid N-hydroxysuccinimide ester Boc-AoAc-NHS N-Bocaminooxy-acetic acid 2,5-dioxo-pyrrolidin-1-yl ester N-Boc-aminooxyacetic acidN-hydroxysuccinimide ester (Assay) N'-Boc-aminooxyacetyl N-hydroxysuccinimide ester Boc-Aoa-NHS N-Succinimidyl (Boc-aminooxy)acetate [(tert-Butoxycbonyl)aminooxy]acetic Acid N-Succinimidyl Ester 2-tert-butoxycarbonylaminoxy-acetic acid 2,5-dioxo-pyrrolidin-1-yl ester 2,5-Dioxo-1-pyrrolidinyl 2-[(Boc-amino)oxy]acetate [2-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-2-oxoethoxy]cbaMic Acid 1,1-DiMethylethyl Ester 2,5-Dioxopyrrolidin-1-yl 2-(((tert-butoxycbonyl)amino)oxy)acetate (BOC-AMINOOXY)ACETIC ACID NHS ESTER 2-[[[(1,1-DiMethylethoxy)carbonyl]amino]oxy]acetic Acid 2,5-Dioxo-1-pyrrolidinyl Ester t-Boc-aminooxyacetic Acid N-Hydroxysuccinimide Ester Acetic acid, 2-[[[(1,1-dimethylethoxy)carbonyl]amino]oxy]-, 2,5-dioxo-1-pyrrolidinyl ester tBoc-aminooxyacetyl N-hydroxysuccinimide ester tBoc-AO-OSu

Description	Boc-NH-O-C1-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Alkyl/ether
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Melting Point	114 °C
Molecular Formula	C₁₁H₁₆N₂O₇
Molecular Weight	288.25400
Exact Mass	288.09600
PSA	114.73000
LogP	0.19220

6066-82-6 structure

6066-82-6

42989-85-5 structure

42989-85-5

~92%

80366-85-4 structure

80366-85-4

Literature: Deroo, Stephanie; Defrancq, Eric; Moucheron, Cecile; Kirsch-De Mesmaeker, Andree; Dumy, Pascal Tetrahedron Letters, 2003 , vol. 44, # 46 p. 8379 - 8382

24424-99-5 structure

24424-99-5

~%

80366-85-4 structure

80366-85-4

Literature: Deroo, Stephanie; Defrancq, Eric; Moucheron, Cecile; Kirsch-De Mesmaeker, Andree; Dumy, Pascal Tetrahedron Letters, 2003 , vol. 44, # 46 p. 8379 - 8382

Precursor 3
6066-82-6 42989-85-5 24424-99-5
DownStream 1
879898-82-5

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