10-methyl-10-deazaaminopterin

Modify Date: 2025-09-10 22:16:01

10-methyl-10-deazaaminopterin structure	Common Name	10-methyl-10-deazaaminopterin
	CAS Number	80576-77-8	Molecular Weight	453.451
	Density	1.5±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₂₁H₂₃N₇O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of 10-methyl-10-deazaaminopterin

10-Methyl-10-deazaaminopterin is a folate analog and an antifolate. 10-Methyl-10-deazaaminopterin can be used for the research of cancer[1].

Name	N-{4-[1-(2,4-Diamino-6-pteridinyl)-2-propanyl]benzoyl}-L-glutamic acid
Synonym	More Synonyms

Description	10-Methyl-10-deazaaminopterin is a folate analog and an antifolate. 10-Methyl-10-deazaaminopterin can be used for the research of cancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Antifolate
References	[1]. Sirotnak FM, et al. New folate analogs of the 10-deaza-aminopterin series. Further evidence for markedly increased antitumor efficacy compared with methotrexate in ascitic and solid murine tumor models. Cancer Chemother Pharmacol. 1984;12(1):26-30.

Density	1.5±0.1 g/cm3
Molecular Formula	C₂₁H₂₃N₇O₅
Molecular Weight	453.451
Exact Mass	453.176056
LogP	0.28
Index of Refraction	1.699
InChIKey	MQISJAZESFPIPJ-SBNLOKMTSA-N
SMILES	CC(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc1

L-Glutamic acid, N-[4-[2-(2,4-diamino-6-pteridinyl)-1-methylethyl]benzoyl]-

N-{4-[1-(2,4-Diamino-6-pteridinyl)-2-propanyl]benzoyl}-L-glutamic acid

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