Pivopril

Modify Date: 2024-01-13 18:45:45

Pivopril Structure
Pivopril structure
Common Name Pivopril
CAS Number 81045-50-3 Molecular Weight 329.45500
Density 1.16g/cm3 Boiling Point 490.431°C at 760 mmHg
Molecular Formula C16H27NO4S Melting Point N/A
MSDS N/A Flash Point 250.4±26.8 °C

 Use of Pivopril


Pivalopril is a new orally active angiotensin converting enzyme (ACE) inhibitor.

 Names

Name (S)-N-cyclopentyl-N-[3-[(2,2-dimethyl-1-oxopropyl)thio]-2-methyl-1-oxopropyl]glycine
Synonym More Synonyms

 Pivopril Biological Activity

Description Pivalopril is a new orally active angiotensin converting enzyme (ACE) inhibitor.
Related Catalog
Target

ACE[1]

In Vivo Pivalopril is a new compound with a hindered sulfur group that has been compared to Captopril for oral angiotensin-converting enzyme (ACE) inhibition in rats and dogs and antihypertensive activity in rats. In separate groups of conscious normotensive rats, Pivalopril (0.03-1.0 mg/kg, orally [p.o.]) produces a dose-related antagonism of angiotensin I (AngI)-induced pressor effects. The ED50 for Pivalopril and Captopril is 0.1 mg/kg. In conscious normotensive dogs, Pivalopril (incremental doses of 0.01-1.0 mg/kg, p.o.) produces a dose-related antagonism of AngI pressor effects. The ED50 is 0.17 mg/kg for Pivalopril and 0.06 mg/kg for Captopril. At equieffective doses the two compounds have similar durations of action. In sodium-deficient, conscious spontaneously hypertensive rats (SHR), Pivalopril (1-100 mg/kg, p.o.) produces a dose-related reduction in mean arterial pressure. The potency and duration are similar to those of Captopril. In the sodium-replete SHR, 5 days of oral dosing with Pivalopril (100 mg/kg per day) decreases mean arterial pressure more effectively than Captopril (100 mg/kg per day). It is concluded that Pivalopril is a potent, orally effective ACE inhibitor and antihypertensive agent[2].
References

[1]. Burnier M, et al. RHC 3659: a new orally active angiotensin converting enzyme inhibitor in normal volunteers. Br J Clin Pharmacol. 1981 Dec;12(6):893-9.

[2]. Wolf PS, et al. Angiotensin-converting enzyme inhibitory and antihypertensive activities of pivalopril (RHC 3659-(S)). Fed Proc. 1984 Apr;43(5):1322-5.

 Chemical & Physical Properties

Density 1.16g/cm3
Boiling Point 490.431°C at 760 mmHg
Molecular Formula C16H27NO4S
Molecular Weight 329.45500
Flash Point 250.4±26.8 °C
Exact Mass 329.16600
PSA 99.98000
LogP 2.78420
Vapour Pressure 0.0±2.7 mmHg at 25°C
Index of Refraction 1.531
Storage condition 2-8℃

 Synonyms

Pivalopril
Pivopril