Aceclidine

Modify Date: 2026-07-05 23:41:25

Aceclidine structure	Common Name	Aceclidine
	CAS Number	827-61-2	Molecular Weight	169.22100
	Density	N/A	Boiling Point	221.5ºC at 760 mmHg
	Molecular Formula	C₉H₁₅NO₂	Melting Point	N/A
	MSDS	N/A	Flash Point	85ºC

Use of Aceclidine

Aceclidine is a modulator of M3 muscarinic acetylcholine receptor. Aceclidine is a cycloplegic agent, a surfactant, a tonicity adjustor and optionally a viscosity enhancer and an antioxidant. Aceclidine has the potential for the research of disorders such as refractive errors of the eye, xerostomia, Sjogren's syndrome, glaucoma, conjunctivitis, lacrimal gland disease, and esotropia (extracted from patent US20150290125A1/US20110091459A1)[1][2].

Name	1-azabicyclo[2.2.2]octan-3-yl acetate
Synonym	More Synonyms

Description	Aceclidine is a modulator of M3 muscarinic acetylcholine receptor. Aceclidine is a cycloplegic agent, a surfactant, a tonicity adjustor and optionally a viscosity enhancer and an antioxidant. Aceclidine has the potential for the research of disorders such as refractive errors of the eye, xerostomia, Sjogren's syndrome, glaucoma, conjunctivitis, lacrimal gland disease, and esotropia (extracted from patent US20150290125A1/US20110091459A1)[1][2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> mAChR Signaling Pathways >> GPCR/G Protein >> mAChR Research Areas >> Neurological Disease
Target	M3 muscarinic acetylcholine receptor[1]
References	[1]. Gerald Horn, et al. Storage Stable Compositions and Methods for the Treatment of Refractive Errors of the Eye. Patent US20150290125A1. [2]. Thomas G. Gant, et al. Imidazole modulators of muscarinic acetylcholine receptor m3. Patent US20110091459A1.

Boiling Point	221.5ºC at 760 mmHg
Molecular Formula	C₉H₁₅NO₂
Molecular Weight	169.22100
Flash Point	85ºC
Exact Mass	169.11000
PSA	29.54000
LogP	0.58160
InChIKey	WRJPSSPFHGNBMG-UHFFFAOYSA-N
SMILES	CC(=O)OC1CN2CCC1CC2

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VD6195000

CHEMICAL NAME :: 3-Quinuclidinol, acetate (ester)

CAS REGISTRY NUMBER :: 827-61-2

LAST UPDATED :: 199603

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C9-H15-N-O2

MOLECULAR WEIGHT :: 169.25

WISWESSER LINE NOTATION :: T66 A B CNTJ AOV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 225 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 18,320,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 45 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 18,320,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 165 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 18,320,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 78 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - analgesia Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 189,295,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 102 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 18,320,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 36 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands Kidney, Ureter, Bladder - urine volume increased

REFERENCE :: RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 35,55,1972

Hazard Codes	Xi
HS Code	2933990090

Ethanoic anhydride

CAS#:108-24-7

3-Quinuclidinol

CAS#:1619-34-7

~90%

Aceclidine

CAS#:827-61-2

Learn More

Literature: Langlois; Meyer; Soulier Synthetic Communications, 1992 , vol. 22, # 13 p. 1895 - 1911

3-Quinuclidinol

CAS#:1619-34-7

~60%

Aceclidine

CAS#:827-61-2

Learn More

Literature: Bracco International B.V. Patent: US5387409 A1, 1995 ;

3-Quinuclidinon...

CAS#:1193-65-3

Aceclidine

CAS#:827-61-2

Learn More

Literature: Helvetica Chimica Acta, , vol. 40, p. 2170,2176

3-acetoxy-1-((m...

CAS#:76656-18-3

Aceclidine

CAS#:827-61-2

Learn More

Literature: Pharmaceutical Chemistry Journal, , vol. 18, # 3 p. 161 - 164 Khimiko-Farmatsevticheskii Zhurnal, , vol. 18, # 3 p. 297 - 300

Precursor 4
CAS#:108-24-7 Ethanoic anhydride CAS#:1619-34-7 3-Quinuclidinol CAS#:1193-65-3 3-Quinuclidinon... CAS#:76656-18-3 3-acetoxy-1-((m...
DownStream 2
CAS#:25333-42-0 (R)-(-)-3-Quinu... CAS#:41967-35-5 1-Azoniabicyclo...

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Name: Binding affinity towards rat Gabra1 in an in vitro assay with cellular components mea...
Source: ChEMBL
Target: Gamma-aminobutyric acid receptor subunit alpha-1
External Id: CHEMBL5291800

Name: Binding affinity towards human ESR1 in an in vitro cell free assay (CRO assay) measur...
Source: ChEMBL
Target: Estrogen receptor
External Id: CHEMBL5291792

Name: Compound was evaluated for inhibition of human F2 in an in vitro cell free assay meas...
Source: ChEMBL
Target: Prothrombin
External Id: CHEMBL5291794

Name: Toxicity to Musca domestica (house fly) assessed as mortality at 75 ug/fly measured a...
Source: ChEMBL
Target: Musca domestica
External Id: CHEMBL3061007

Name: Ability to stimulate phosphoinositol metabolism was examined in the rat cerebral cort...
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL795511

Name: Binding affinity against muscarinic acetylcholine receptor from rat brain crude membr...
Source: ChEMBL
Target: Muscarinic acetylcholine receptor M2
External Id: CHEMBL747589

Name: Toxicity to Musca domestica (house fly) assessed as mortality at 75 ug/fly measured a...
Source: ChEMBL
Target: Musca domestica
External Id: CHEMBL3061008

Name: Binding affinity against muscarinic acetylcholine receptor from rat brain crude membr...
Source: ChEMBL
Target: N/A
External Id: CHEMBL747590

Name: Toxicity to Musca domestica (house fly) assessed as mortality at 75 ug/fly measured a...
Source: ChEMBL
Target: Musca domestica
External Id: CHEMBL3061009

Name: Identifying Sarm1 Tir Hydrolase inhibitors through NAD-Glo assay
Source: 24386
Target: N/A
External Id: Sarm1 Tir NADase inhibitors screen

Total 130, Current Page 1 of 13

3-Acetoxyquinuclidine

Quinuclidin-3-yl acetate

aceclidine

Glaucostat

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China
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Aceclidine

Use of Aceclidine

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Aceclidine Biological Activity

Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Safety Information

Synthetic Route

Precursor & DownStream

Customs

AceclidineBioassay

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.