Levonordefrin;Corbadrine

Modify Date: 2026-07-01 15:00:49

Levonordefrin;Corbadrine Structure
Levonordefrin;Corbadrine structure
Common Name Levonordefrin;Corbadrine
CAS Number 829-74-3 Molecular Weight 183.20
Density 1.328g/cm3 Boiling Point 431.575ºC at 760 mmHg
Molecular Formula C9H13NO3 Melting Point 212-215ºC dec.
MSDS Chinese USA Flash Point 214.809ºC
Symbol GHS07
GHS07
Signal Word Warning

 Use of Levonordefrin;Corbadrine


Levonordefrin, a common alternative to levoepinephrine as a vasoconstrictor in dental local anesthetic preparations, is usually used in fivefold higher concentrations. Levonordefrin is generally considered equivalent to epinephrine[1].

 Names

Name (-)-3,4-Dihydroxynorephedrine
Synonym More Synonyms

 Levonordefrin;Corbadrine Biological Activity

Description Levonordefrin, a common alternative to levoepinephrine as a vasoconstrictor in dental local anesthetic preparations, is usually used in fivefold higher concentrations. Levonordefrin is generally considered equivalent to epinephrine[1].
Related Catalog
References

[1]. Robertson VJ, et al. Quantitative and qualitative analysis of the pressor effects of levonordefrin.

 Chemical & Physical Properties

Density 1.328g/cm3
Boiling Point 431.575ºC at 760 mmHg
Melting Point 212-215ºC dec.
Molecular Formula C9H13NO3
Molecular Weight 183.20
Flash Point 214.809ºC
Exact Mass 183.09000
PSA 86.71000
LogP 1.17870
Index of Refraction 1.633
InChIKey GEFQWZLICWMTKF-CDUCUWFYSA-N
SMILES CC(N)C(O)c1ccc(O)c(O)c1

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302 + H312 + H332-H315-H319-H335
Precautionary Statements P261-P280-P301 + P312 + P330-P305 + P351 + P338
Hazard Codes Xn: Harmful;
Risk Phrases R20/21/22;R36/37/38
Safety Phrases S26-S36
RIDADR UN 2811 6.1 / PGII
HS Code 2922509090

 Synthetic Route

~%

Levonordefrin;Corbadrine Structure

Levonordefrin;C...

CAS#:829-74-3

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Literature: DE639126 , ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 23, p. 481

 Precursor & DownStream

Precursor  1

DownStream  0

 Customs

HS Code 2922509090
Summary 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Levonordefrin;CorbadrineBioassay

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Name: Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
Source: NCGC
External Id: SNCA-p-activity-luciferase
Name: Selectivity ratio of Ki of alpha-1 adrenergic receptor to alpha-2 receptor
Source: ChEMBL
Target: Alpha-2A adrenergic receptor
External Id: CHEMBL847971
Name: Increase the activity of the Burkholderia fixLJ 2-component system
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: Burkholderia multivorans
External Id: HMS1625
Name: Dicer-mediated maturation of pre-microRNA
Source: Center for Chemical Genomics, University of Michigan
Target: N/A
External Id: TargetID_659_CEMA
Name: p53 small molecule agonists, cell-based qHTS assay
Source: 824
External Id: P53344
Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS233
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 Synonyms

4-[(1R,2S)-2-amino-1-hydroxypropyl]benzene-1,2-diol
LEVONORDEFRIN
1(S),2(R)-(+)-nordefrin
MFCD00134415
(-)-Nordefrin
Neo-cobefrin
Levonordefrin Base
Levonordefrin (200 mg)
D-(-)-Cobefrin
l-Cobefrin
BA 2818
CORBADRINE
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