Bonducellin

Modify Date: 2024-02-13 13:00:22

Bonducellin Structure
Bonducellin structure
Common Name Bonducellin
CAS Number 83162-84-9 Molecular Weight 282.29
Density N/A Boiling Point N/A
Molecular Formula C17H14O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Bonducellin


Bonducellin is a a homoisoflavonoid, which can be isolated from Caesalpinia digyna roots. Bonducellin is a potent inhibitor of efflux pump (EP), while EP induces resistance in mycobacteria and serves as a target of anti-TB (tuberculosis) agents. Bonducellin reduces MIC of EtBr by 8-fold against M. smegmatis (MIC=62.5 mg/L)[1].

 Names

Name Bonducellin
Synonym More Synonyms

 Bonducellin Biological Activity

Description Bonducellin is a a homoisoflavonoid, which can be isolated from Caesalpinia digyna roots. Bonducellin is a potent inhibitor of efflux pump (EP), while EP induces resistance in mycobacteria and serves as a target of anti-TB (tuberculosis) agents. Bonducellin reduces MIC of EtBr by 8-fold against M. smegmatis (MIC=62.5 mg/L)[1].
Related Catalog
References

[1]. Roy SK, et al. 7-Hydroxy-(E)-3-phenylmethylene-chroman-4-one analogues as efflux pump inhibitors against Mycobacterium smegmatis mc² 155. Eur J Med Chem. 2013 Aug;66:499-507.  

 Chemical & Physical Properties

Molecular Formula C17H14O4
Molecular Weight 282.29
Exact Mass 282.08900
PSA 55.76000
LogP 3.05950

 Precursor & DownStream

Precursor  0

DownStream  1

 Synonyms

(E)-7-hydroxy-3-(4'-methoxybenzylidene)chroman-4-one
7-hydroxy-(E)-3-[(4-methoxyphenyl)methylene]chroman-4-one
bonducellin
(E)-7-hydroxy-3-(4-methoxybenzylidene)chroman-4-one
(3E)-2,3-dihydro-7-hydroxy-3-[(4-methoxyphenyl)-methylene]-4H-1-benzopyran-4-one
bonducelline
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