3,7-Dichloroquinoline-8-carboxylic acid

Modify Date: 2024-01-02 18:29:32

3,7-Dichloroquinoline-8-carboxylic acid Structure
3,7-Dichloroquinoline-8-carboxylic acid structure
Common Name 3,7-Dichloroquinoline-8-carboxylic acid
CAS Number 84087-01-4 Molecular Weight 242.058
Density 1.6±0.1 g/cm3 Boiling Point 405.4±40.0 °C at 760 mmHg
Molecular Formula C10H5Cl2NO2 Melting Point 274ºC
MSDS Chinese USA Flash Point 199.0±27.3 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of 3,7-Dichloroquinoline-8-carboxylic acid


Quinclorac, an herbicide widely applied in agriculture, induces oxidative stress due to free radical generation and changes in the antioxidant defense system[1].

 Names

Name quinclorac
Synonym More Synonyms

 3,7-Dichloroquinoline-8-carboxylic acid Biological Activity

Description Quinclorac, an herbicide widely applied in agriculture, induces oxidative stress due to free radical generation and changes in the antioxidant defense system[1].
Related Catalog
References

[1]. Cavalheiro de Menezes C, et al. The effects of diphenyl diselenide on oxidative stress biomarkers in Cyprinus carpio exposed to herbicide quinclorac (Facet®). Ecotoxicol Environ Saf. 2012;81:91-97.

 Chemical & Physical Properties

Density 1.6±0.1 g/cm3
Boiling Point 405.4±40.0 °C at 760 mmHg
Melting Point 274ºC
Molecular Formula C10H5Cl2NO2
Molecular Weight 242.058
Flash Point 199.0±27.3 °C
Exact Mass 240.969727
PSA 50.19000
LogP 2.11
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.695

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VB1984000
CHEMICAL NAME :
8-Quinolinecarboxylic acid, 3,7-dichloro-
CAS REGISTRY NUMBER :
84087-01-4
LAST UPDATED :
199710
DATA ITEMS CITED :
14
MOLECULAR FORMULA :
C10-H5-Cl2-N-O2
MOLECULAR WEIGHT :
242.06

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2190 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 15,647,1990
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>5170 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 15,647,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 15,647,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 15,647,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Bird - quail
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094) Volume(issue)/page/year: -,C133,1991 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
50400 mg/kg/4W-C
TOXIC EFFECTS :
Liver - changes in liver weight Kidney, Ureter, Bladder - other changes Related to Chronic Data - changes in testicular weight
REFERENCE :
NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 15,647,1990
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
65520 mg/kg/13W-C
TOXIC EFFECTS :
Blood - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes
REFERENCE :
NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 15,647,1990
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
53760 mg/kg/4W-C
TOXIC EFFECTS :
Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases
REFERENCE :
NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 15,647,1990
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
175 gm/kg/13W-C
TOXIC EFFECTS :
Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Blood - changes in other cell count (unspecified)
REFERENCE :
NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 15,647,1990
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
6300 mg/kg/4W-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - interstitial nephritis Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases Related to Chronic Data - changes in testicular weight
REFERENCE :
NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 15,647,1990
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
110 gm/kg/1Y-C
TOXIC EFFECTS :
Liver - changes in liver weight Kidney, Ureter, Bladder - other changes Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 15,647,1990 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
7800 mg/kg
SEX/DURATION :
female 7-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 15,647,1990

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H317
Precautionary Statements P280
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes Xi:Irritant;
Risk Phrases R43
Safety Phrases 2-24-37
RIDADR 1993
RTECS VB1984000
Packaging Group III
Hazard Class 3.2
HS Code 2933499014

 Synthetic Route

~93%

3,7-Dichloroquinoline-8-carboxylic acid Structure

3,7-Dichloroqui...

CAS#:84087-01-4

Literature: BASF Aktiengesellschaft Patent: US4497651 A1, 1985 ;

 Precursor & DownStream

Precursor  1

DownStream  0

 Customs

HS Code 2933499014
Summary 2933499014 3,7-dichloroquinoline-8-carboxylic acid。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:20.0%

 Articles3

More Articles
The diageotropica mutation and synthetic auxins differentially affect the expression of auxin-regulated genes in tomato.

Plant Physiol. 109(1) , 293-7, (1995)

The effect of a tomato (Lycopersicon esculentum) mutation, diageotropica (dgt), on the accumulation of mRNA corresponding to tomato homologs of three auxin-regulated genes, LeAux, LeSAUR, and Lepar, w...

Phylogenetic and degradation characterization of Burkholderia cepacia WZ1 degrading herbicide quinclorac.

J. Environ. Sci. Health B 38(6) , 771-82, (2003)

Strain WZI capable of degrading quinclorac was isolated from a pesticide manufactory soil and considered to be Burkholderia cepacia, belonged to bacteria, Proteobacteria, beta-Proteobacteria, based on...

Influences of quinclorac on culturable microorganisms and soil respiration in flooded paddy soil.

Biomed. Environ. Sci. 16(4) , 314-22, (2003)

To investigate the potential effects of herbicide quinclorac (3,7-dichloro-8-quinoline-carboxylic) on the culturable microorganisms in flooded paddy soil.Total soil aerobic bacteria, actinomycetes and...

 Synonyms

FAS-NOX
3,7-dichloroquinoline-8-carboxylic acid
3,7-dichloro-8-quinoline carboxylic acid
BAS 514
Facet 75 DF
Parmount
FACET
Quinclorac
T66 BNJ DG IG JVQ
QUEEN
MFCD00072495
3,7-dichloro-quinoline-8-carboxylic acid
BAS-514-H
8-Quinolinecarboxylic acid, 3,7-dichloro-
Drive
Facet LA
EINECS 402-780-1
3,7-Dichloro-8-quinolinecarboxylic acid
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