2',3'-dideoxyuridine-5'-triphosphate

Modify Date: 2024-04-03 17:40:13

2',3'-dideoxyuridine-5'-triphosphate Structure
2',3'-dideoxyuridine-5'-triphosphate structure
Common Name 2',3'-dideoxyuridine-5'-triphosphate
CAS Number 84445-38-5 Molecular Weight 452.14
Density N/A Boiling Point N/A
Molecular Formula C9H15N2O13P3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 2',3'-dideoxyuridine-5'-triphosphate


ddUTP (2′,3′-Dideoxyuridine-5′-triphosphate) is a selective HIV and AMV reverse transcriptase inhibitor with Ki values of 0.05 µM and 1 µM, respectively. ddUTP is incorporated into the growing DNA strand primarily at dTTP sites and inhibits further elongation[1].

 Names

Name Deoxyuridine triphosphate

 2',3'-dideoxyuridine-5'-triphosphate Biological Activity

Description ddUTP (2′,3′-Dideoxyuridine-5′-triphosphate) is a selective HIV and AMV reverse transcriptase inhibitor with Ki values of 0.05 µM and 1 µM, respectively. ddUTP is incorporated into the growing DNA strand primarily at dTTP sites and inhibits further elongation[1].
Related Catalog
References

[1]. Hao Z, Potent DNA chain termination activity and selective inhibition of human immunodeficiency virus reverse transcriptase by 2',3'-dideoxyuridine-5'-triphosphate. Mol Pharmacol. 1990 Feb;37(2):157-63.  

 Chemical & Physical Properties

Molecular Formula C9H15N2O13P3
Molecular Weight 452.14
Exact Mass 451.97900
PSA 253.34000