tris succinate

Modify Date: 2024-01-02 16:35:50

tris succinate structure	Common Name	tris succinate
	CAS Number	84540-64-7	Molecular Weight	360.35800
	Density	N/A	Boiling Point	633.5ºC at 760 mmHg
	Molecular Formula	C₁₂H₂₈N₂O₁₀	Melting Point	138-141ºC
	MSDS	N/A	Flash Point	336.9ºC

Use of tris succinate

Succinic acid tromethamine is a potent and orally active anxiolytic agent. Succinic acid tromethamine is an intermediate product of the tricarboxylic acid cycle. Succinic acid tromethamine can be used as a precursor of many industrially important chemicals in food, chemical and pharmaceutical industries[1][2][3].

Name	tris succinate
Synonym	More Synonyms

Description	Succinic acid tromethamine is a potent and orally active anxiolytic agent. Succinic acid tromethamine is an intermediate product of the tricarboxylic acid cycle. Succinic acid tromethamine can be used as a precursor of many industrially important chemicals in food, chemical and pharmaceutical industries[1][2][3].
Related Catalog	Research Areas >> Neurological Disease
Target	Microbial Metabolite Human Endogenous Metabolite
In Vitro	Succinic acid tromethamine is derived from the fermentation of agricultural carbohydrates[2].
In Vivo	Succinic acid tromethamine (3, 6 mg/kg; p.o.) increases the percentage of entries into open arms and of time spent on open arms in male mice[3]. Succinic acid tromethamine (3, 6, 12 mg/kg; i.p.) significant increases in food intake during 5 min, and 40 min after drug administration rectal temperature was measured, succinic acid at a dose of 1.5 mg/kg, inhibited stress-induced hyperthermia[3].
References	[1]. Zhang YJ, et al. Optimization of succinic acid fermentation with Actinobacillus succinogenes by response surface methodology (RSM). J Zhejiang Univ Sci B. 2012 Feb;13(2):103-10. [2]. A T JOHNS, et al. The production of propionic acid by decarboxylation of succinic acid in a bacterial fermentation. Biochem J. 1948;42(1):ii. [3]. Si Wei Chen, Anxiolytic-like effect of succinic acid in mice. Life Sci. 2003 Nov 7;73(25):3257-64.

Boiling Point	633.5ºC at 760 mmHg
Melting Point	138-141ºC
Molecular Formula	C₁₂H₂₈N₂O₁₀
Molecular Weight	360.35800
Flash Point	336.9ºC
Exact Mass	360.17400
PSA	248.02000

Name:	Tris-succinate 99% Material Safety Data Sheet
Synonym:	Tris(hydroxymethyl)aminomethane succinate
CAS:	84540-64-7

Section 1 - Chemical Product MSDS Name:Tris-succinate 99% Material Safety Data Sheet
Synonym:Tris(hydroxymethyl)aminomethane succinate

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
84540-64-7	Tris-succinate	99	283-159-0

Hazard Symbols: None Listed.
Risk Phrases: None Listed.

Section 3 - HAZARDS IDENTIFICATION

EMERGENCY OVERVIEW
Not available.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion:
The toxicological properties of this substance have not been fully investigated.
Inhalation:
Dust is irritating to the respiratory tract.
Chronic:
No information found.

Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists.
Ingestion:
Get medical aid. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. Get medical aid if cough or other symptoms appear.
Notes to Physician:

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use foam, dry chemical, or carbon dioxide.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Avoid generating dusty conditions. Provide ventilation.

Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Avoid breathing dust.
Storage:
Store in a cool, dry place. Store in a tightly closed container.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower.
Exposure Limits CAS# 84540-64-7: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to minimize contact with skin.
Respirators:
A NIOSH/MSHA approved air purifying dust or mist respirator or European Standard EN 149.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Powder
Color: white
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 138 - 141 deg C
Autoignition Temperature: Not available.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: soluble in water 1 g/10ml
Specific Gravity/Density:
Molecular Formula: C8H22N2O6.C4H6O4
Molecular Weight: 360.35

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Dust generation.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Carbon monoxide, oxides of nitrogen, carbon dioxide.
Hazardous Polymerization: Has not been reported.

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 84540-64-7 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
Tris-succinate - Not listed by ACGIH, IARC, or NTP.

Section 12 - ECOLOGICAL INFORMATION

Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

IATA
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
IMO
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
RID/ADR
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing group:

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 84540-64-7: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 84540-64-7 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 84540-64-7 is not listed on the TSCA inventory.
It is for research and development use only.

SECTION 16 - ADDITIONAL INFORMATION
N/A

Safety Phrases	24/25

TRIS(HYDROXYMETHYL)AMINOMETHANE SUCCINATE

TRIS-SUCCINATE

succinic acid,compound with 2-amino-2-(hydroxymethyl)propane-1,3-diol (1:1)

TRIZMA SUCCINATE

DI[TRIS(HYDROXYMETHYL)AMINOMETHANE] SUCCINATE

2-AMINO-2-(HYDROXYMETHYL)-1,3-PROPANEDIOL SUCCINATE

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: TRIS SUCCINATE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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