Eurycomanone

Modify Date: 2024-01-02 17:31:25

Eurycomanone Structure
Eurycomanone structure
 Common Name Eurycomanone
CAS Number 84633-29-4 Molecular Weight 408.40
Density N/A Boiling Point N/A
Molecular Formula C20H24O9 Melting Point 273-285℃ (methanol ethyl ether )
MSDS N/A Flash Point N/A

 Use of Eurycomanone


Eurycomanone could increases spermatogenesis by inhibiting the activity of phosphodiesterase and aromatase in steroidogenesis.

 Names

Name eurycomanone
Synonym More Synonyms

 Eurycomanone Biological Activity

Description Eurycomanone could increases spermatogenesis by inhibiting the activity of phosphodiesterase and aromatase in steroidogenesis.
Related Catalog
In Vitro Eurycomanone (EN) significantly increased testosterone production dose-dependently at 0.1, 1.0 and 10.0 μM, but the two lower doses when combined with 3-isobutyl-1-methylxanthine (IBMX), the phosphodiesterase inhibitor were not significantly higher than EN or IBMX alone, except at a higher concentration. The molecular docking studies indicated EN and IBMX were binding at different sites of the enzyme. EN has no reversal of inhibition by aminoglutethimide, ketoconazole or nifedipine at the respective steroid oogenesis enzyme. The quassinoid was also non-responsive to the inhibition of oestrogen receptor by tamoxifen, but displayed improved for mestane inhibition of aromatase in reducing oestrogen production. The molecular docking studies further supported that EN and formestane bound to aromatase with similar orientations and free energy binding values[1].
References

[1]. Low BS, et al. Eurycomanone, the major quassinoid in Eurycoma longifolia root extract increases spermatogenesis by inhibiting the activity of phosphodiesterase and aromatase in steroidogenesis. J Ethnopharmacol. 2013 Aug 26;149(1):201-7.

 Chemical & Physical Properties

Melting Point 273-285℃ (methanol ethyl ether )
Molecular Formula C20H24O9
Molecular Weight 408.40
PSA 172.21000
Storage condition 2-8℃

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TJ7862500
CHEMICAL NAME :
Picrasa-3,13(21)-diene-2,16-dione, 11,2O-epoxy-1,11,12,14,15-pentahydroxy-, (1-beta,11- beta,12-alpha,15-beta)-, dihydrate
CAS REGISTRY NUMBER :
84633-29-4
LAST UPDATED :
199303
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C20-H24-O9.2H2-O
MOLECULAR WEIGHT :
444.48

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
18900 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 26,345,1991

 Precursor & DownStream

Precursor  0

DownStream  1

 Synonyms

(1β,11α,12α,15β)-1,11,12,14,15-Pentahydroxy-11,20-epoxypicrasa-3,13(21)-diene-2,16-dione dihydrate
pasakbumin-a
EURYCOMANONE
Picrasa-3,13(21)-diene-2,16-dione, 11,20-epoxy-1,11,12,14,15-pentahydroxy-, (1β,11α,12α,15β)-, hydrate (1:2)
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