2,6-Dimethyl-3,5-dimethoxycarbonyl-4-(p-difluoromethoxyphenyl)-1,4-dih ydropyridine

Modify Date: 2025-08-25 15:28:04

2,6-Dimethyl-3,5-dimethoxycarbonyl-4-(p-difluoromethoxyphenyl)-1,4-dih ydropyridine structure	Common Name	2,6-Dimethyl-3,5-dimethoxycarbonyl-4-(p-difluoromethoxyphenyl)-1,4-dih ydropyridine
	CAS Number	84761-71-7	Molecular Weight	367.34400
	Density	1.242g/cm3	Boiling Point	455.5ºC at 760 mmHg
	Molecular Formula	C₁₈H₁₉F₂NO₅	Melting Point	N/A
	MSDS	N/A	Flash Point	229.3ºC

Name	dimethyl 4-[4-(difluoromethoxy)phenyl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Density	1.242g/cm3
Boiling Point	455.5ºC at 760 mmHg
Molecular Formula	C₁₈H₁₉F₂NO₅
Molecular Weight	367.34400
Flash Point	229.3ºC
Exact Mass	367.12300
PSA	73.86000
LogP	3.19760
Index of Refraction	1.509
InChIKey	FXAPKJSBQQAVQY-UHFFFAOYSA-N
SMILES	COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1ccc(OC(F)F)cc1

CHEMICAL IDENTIFICATION

RTECS NUMBER :: US7969600

CHEMICAL NAME :: 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-4-(4-(difluoromethoxy)phenyl)-2,6-dimethy l-, dimethyl ester

CAS REGISTRY NUMBER :: 84761-71-7

LAST UPDATED :: 199712

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C18-H19-F2-N-O5

MOLECULAR WEIGHT :: 367.38

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Vascular - BP lowering not characterized in autonomic section Vascular - regional or general arteriolar or venous dilation

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 16,817,1982

4-(Difluoromethoxy)benzaldehyde structure

4-(Difluorometh...

CAS#:73960-07-3

Methyl acetoacetate structure

Methyl acetoacetate

CAS#:105-45-3

~57%

2,6-Dimethyl-3,5-dimethoxycarbonyl-4-(p-difluoromethoxyphenyl)-1,4-dih ydropyridine Structure

2,6-Dimethyl-3,...

CAS#:84761-71-7

Literature: Kastron, V. V.; Dubur, G. Ya.; Vitolin', R. O.; Kimenis, A. A.; Selga, M. Ya.; et al. Pharmaceutical Chemistry Journal, 1982 , vol. 16, # 11 p. 817 - 824 Khimiko-Farmatsevticheskii Zhurnal, 1982 , vol. 16, # 11 p. 1322 - 1329

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